2010
OC-052 Assessment of novel genetic polymorphisms and risk of upper gastrointestinal carcinoma
Hold G, El-Omar E, Chow W, Risch H, Gammon M, Vaughan T, Lissowska J, Lochhead P, Rabkin C, Ng M. OC-052 Assessment of novel genetic polymorphisms and risk of upper gastrointestinal carcinoma. Gut 2010, 59: a21. DOI: 10.1136/gut.2009.208959z.Peer-Reviewed Original ResearchCase-control studyOesophageal cancerGastric cancer case-control studySolid tumorsNon-cardia gastric cancerMajor global health problemUpper GI cancerSquamous cell oesophageal cancerUpper gastrointestinal malignanciesRisk of gastricUpper gastrointestinal carcinomasCancer case-control studyGastric Cancer StudyGastric adenocarcinoma patientsGlobal health problemGastrointestinal malignanciesAdenocarcinoma patientsColorectal cancerGastrointestinal carcinomasGI cancersGastric adenocarcinomaNovel genetic polymorphismsRisk factorsGastric cancerElevated risk
2007
Inducible nitric oxide synthase, nitrotyrosine and p53 mutations in the molecular pathogenesis of Barrett's esophagus and esophageal adenocarcinoma
Vaninetti NM, Geldenhuys L, Porter GA, Risch H, Hainaut P, Guernsey DL, Casson AG. Inducible nitric oxide synthase, nitrotyrosine and p53 mutations in the molecular pathogenesis of Barrett's esophagus and esophageal adenocarcinoma. Molecular Carcinogenesis 2007, 47: 275-285. PMID: 17849424, DOI: 10.1002/mc.20382.Peer-Reviewed Original ResearchConceptsInducible nitric oxide synthaseINOS mRNA expressionEsophageal adenocarcinomaNitric oxide synthaseP53 mutationsNitric oxideBarrett's esophagusOxide synthaseMRNA expressionEndogenous p53 mutationsGastroesophageal reflux diseaseActive inflammatory processPrimary esophageal adenocarcinomaPotential causative factorsReflux diseaseGastrointestinal malignanciesChronic inflammationINOS overexpressionEsophageal malignancyInflammatory processNormal epitheliumHuman premalignantEsophageal epitheliumMolecular pathogenesisSignificant association