The effect of leukemia inhibitory factor (LIF) on trophoblast differentiation: a potential role in human implantation
Nachtigall MJ, Kliman HJ, Feinberg RF, Olive DL, Engin O, Arici A. The effect of leukemia inhibitory factor (LIF) on trophoblast differentiation: a potential role in human implantation. The Journal Of Clinical Endocrinology & Metabolism 1996, 81: 801-806. PMID: 8636307, DOI: 10.1210/jcem.81.2.8636307.Peer-Reviewed Original ResearchMeSH KeywordsBlotting, NorthernCell DifferentiationCells, CulturedChorionic GonadotropinChorionic Gonadotropin, beta Subunit, HumanEmbryo ImplantationFemaleFibronectinsGene ExpressionGrowth InhibitorsHumansInterleukin-6Leukemia Inhibitory FactorLymphokinesPregnancyProgesteroneRNA, MessengerTrophoblastsConceptsLeukemia inhibitory factorHuman cytotrophoblastsMenstrual cycle-dependent mannerInhibitory factorOncofetal fibronectinEffects of LIFHuman implantationHuman embryonic implantationBeta-HCG mRNAOncofetal fibronectin mRNAMessenger RNA expressionExtravillous phenotypeBeta-hCGMenstrual cycleHuman endometriumNormal implantationEmbryonic implantationProgesterone productionHCG mRNATerm placentaBiochemical markersCultured trophoblastsHuman CGDay 19Steroidogenic activityEndocrinology and paracrinology
Arici A, Tazuke SI, Attar E, Kliman HJ, Olive DL. Endocrinology and paracrinology. Molecular Human Reproduction 1996, 2: 40-45. PMID: 9238656, DOI: 10.1093/molehr/2.1.40.Peer-Reviewed Original ResearchConceptsIL-8 mRNAIL-1 alphaEnzyme-linked immunosorbent assayIL-8 concentrationsPathogenesis of endometriosisInterleukin-8IL-8 proteinPeritoneal fluidMesothelial cellsPg/Human recombinant IL-1 alphaRecombinant IL-1 alphaNeutrophil chemotactic activityMinimal-mild endometriosisPeritoneal mesothelial cellsInterleukin-8 expressionCultured mesothelial cellsPotent angiogenic agentTNF-alpha treatmentModerate-severe endometriosisHuman mesothelial cellsNon-treated cellsControl patientsTime-dependent mannerTNF-alpha