2018
Type I interferons instigate fetal demise after Zika virus infection
Yockey LJ, Jurado KA, Arora N, Millet A, Rakib T, Milano KM, Hastings AK, Fikrig E, Kong Y, Horvath TL, Weatherbee S, Kliman HJ, Coyne CB, Iwasaki A. Type I interferons instigate fetal demise after Zika virus infection. Science Immunology 2018, 3 PMID: 29305462, PMCID: PMC6049088, DOI: 10.1126/sciimmunol.aao1680.Peer-Reviewed Original ResearchConceptsZika virus infectionZIKV infectionI IFNsI interferonType I interferonGrowth restrictionFetal demiseVirus infectionSevere fetal growth restrictionType I IFNsChorionic villous explantsAdverse fetal outcomesCongenital viral infectionFetal growth restrictionMaternal-fetal barrierType IFunctional type IPlacental damageFetal outcomesPregnancy complicationsEarly pregnancyFetal resorptionZIKV diseasePregnant damsSpontaneous abortion
2017
Placental 11 β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) expression very early during human pregnancy
Salvante KG, Milano K, Kliman HJ, Nepomnaschy PA. Placental 11 β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) expression very early during human pregnancy. Journal Of Developmental Origins Of Health And Disease 2017, 8: 149-154. PMID: 28112069, DOI: 10.1017/s2040174416000611.Peer-Reviewed Original ResearchConceptsProtective roleHydroxysteroid dehydrogenase type 2Intra-uterine growth restrictionType 2 expressionUterine endometrial glandsCritical protective roleDehydrogenase type 2Maternal-fetal exchangeHypothesized protective roleColumnar epithelial cellsGlucocorticoid exposureEndometrial glandsHuman pregnancyBirth weightGrowth restrictionCortisol exposurePlacental expressionBioactive cortisolHuman fetusesType 2Postnatal developmentPhysiologic stressEpithelial cellsImmunocytochemical analysisDevelopmental outcomes
2009
Determination of Placental Weight Using Two-dimensional Sonography and Volumetric Mathematic Modeling
Azpurua H, Funai E, Coraluzzi L, Doherty L, Sasson I, Kliman M, Kliman H. Determination of Placental Weight Using Two-dimensional Sonography and Volumetric Mathematic Modeling. American Journal Of Perinatology 2009, 27: 151-155. PMID: 19653142, DOI: 10.1055/s-0029-1234034.Peer-Reviewed Original ResearchConceptsIntrauterine fetal demisePlacental weightPlacental volumePerinatal complicationsTwo-dimensional sonographyFetal growth restrictionThird trimester pregnancyHours of birthRoutine prenatal careHigh-risk casesSignificant correlationTwo-dimensional ultrasoundPlacental widthPreterm gestationFetal demisePrenatal careSubgroup analysisGrowth restrictionFetal movementsComplicationsSonographySpearman's rhoIUGRPregnancyGestation
2007
Reference Weights for Placentas Delivered before the 28th Week of Gestation
Hecht JL, Kliman HJ, Allred EN, Pflueger SM, Chang C, Doss BJ, Roberts D, Livasy CA, Bhan I, Zambrano E, Ross DW, Senagore P, Husain AN, Leviton A. Reference Weights for Placentas Delivered before the 28th Week of Gestation. Placenta 2007, 28: 987-990. PMID: 17573110, DOI: 10.1016/j.placenta.2007.04.009.Peer-Reviewed Original ResearchConceptsPost-menstrual weeksSingleton placentasBirth weightPlacenta weightBirth weight z-scoreStandard weight tableWeight z-scoreSmall birth weightWeeks of gestationFetal indicationsLive infantsGestational ageTwin placentasPoor perfusionGrowth restrictionLarger sample sizeZ-scorePlacentaWeeksFetal processesStandard weightReference weightSample sizePreeclampsiaPregnancy