2019
P573Effects of mobile text messaging on glycemic control in patients with coronary heart disease and diabetes mellitus: a randomized controlled trial
Huo X, Krumholz H, Bai X, Spatz E, Ding Q, Horak P, Zhao W, Gong Q, Yan X, Wu X, Li J, Li X, Spertus J, Masoudi F, Zheng X. P573Effects of mobile text messaging on glycemic control in patients with coronary heart disease and diabetes mellitus: a randomized controlled trial. European Heart Journal 2019, 40: ehz747.0184. DOI: 10.1093/eurheartj/ehz747.0184.Peer-Reviewed Original ResearchCoronary heart diseaseIntervention groupPhysical activityControl groupGlycemic controlHeart diseaseBaseline 6 monthsHigh-risk patientsText messaging programsSecondary outcome analysisMobile health interventionsText message programMean change differenceBP controlGlycemic hemoglobinHbA1c levelsLifestyle modificationUsual careDiabetes mellitusFamily Planning CommissionPrimary outcomeLifestyle recommendationsMonth followRisk factorsClinical trialsSubmissions from the SPRINT Data Analysis Challenge on clinical risk prediction: a cross-sectional evaluation
Jackevicius CA, An J, Ko DT, Ross JS, Angraal S, Wallach JD, Koh M, Song J, Krumholz HM. Submissions from the SPRINT Data Analysis Challenge on clinical risk prediction: a cross-sectional evaluation. BMJ Open 2019, 9: e025936. PMID: 30904868, PMCID: PMC6475140, DOI: 10.1136/bmjopen-2018-025936.Peer-Reviewed Original ResearchConceptsRisk prediction toolsCross-sectional evaluationClinical risk predictionClinical performanceCardiovascular disease historyClinical risk scoreHigh-risk patientsLow-risk patientsClinical prediction toolRisk predictionEfficacy outcomesC-statisticDisease historyInclusion criteriaIndependent reviewersRisk scoreExternal validationPatientsPrediction toolsEfficacyOutcomesSame outcome
2018
Risk Factors Associated With Major Cardiovascular Events 1 Year After Acute Myocardial Infarction
Wang Y, Li J, Zheng X, Jiang Z, Hu S, Wadhera RK, Bai X, Lu J, Wang Q, Li Y, Wu C, Xing C, Normand SL, Krumholz HM, Jiang L. Risk Factors Associated With Major Cardiovascular Events 1 Year After Acute Myocardial Infarction. JAMA Network Open 2018, 1: e181079-e181079. PMID: 30646102, PMCID: PMC6324290, DOI: 10.1001/jamanetworkopen.2018.1079.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMajor cardiovascular eventsCardiovascular eventsRisk factorsC-statisticMyocardial infarctionAggressive risk factor reductionOne-year event ratesSubsequent major cardiovascular eventsRecurrent acute myocardial infarctionIndex AMI hospitalizationRisk factor reductionHigh-risk patientsProspective cohort studyCoronary heart diseaseLow-risk groupAcute care hospitalsCohort studyCommon comorbiditiesHeart failureMean ageRisk modelHeart diseaseMAIN OUTCOMEHigh risk
2012
Appropriate And Inappropriate Imaging Rates For Prostate Cancer Go Hand In Hand By Region, As If Set By Thermostat
Makarov DV, Desai R, Yu JB, Sharma R, Abraham N, Albertsen PC, Krumholz HM, Penson DF, Gross CP. Appropriate And Inappropriate Imaging Rates For Prostate Cancer Go Hand In Hand By Region, As If Set By Thermostat. Health Affairs 2012, 31: 730-740. PMID: 22492890, DOI: 10.1377/hlthaff.2011.0336.Peer-Reviewed Original ResearchConceptsInappropriate imagingAppropriate imagingProstate cancerHigh-risk prostate cancerHigh rateHigh-risk patientsHealth care utilizationProstate cancer patientsCross-sectional studyOverall imaging rateHealth care costsLower ratesCare utilizationCancer patientsAppropriate treatmentAdvanced imagingCare costsPatientsHealth care organizationsCare organizationsCancerCost containmentImagingImaging rateRegional variationPreoperative Serum Brain Natriuretic Peptide and Risk of Acute Kidney Injury After Cardiac Surgery
Patel UD, Garg AX, Krumholz HM, Shlipak MG, Coca SG, Sint K, Thiessen-Philbrook H, Koyner JL, Swaminathan M, Passik CS, Parikh CR. Preoperative Serum Brain Natriuretic Peptide and Risk of Acute Kidney Injury After Cardiac Surgery. Circulation 2012, 125: 1347-1355. PMID: 22322531, PMCID: PMC3312808, DOI: 10.1161/circulationaha.111.029686.Peer-Reviewed Original ResearchConceptsSevere acute kidney injuryMild acute kidney injuryAcute kidney injuryPostoperative acute kidney injuryCardiac surgeryPreoperative BNPKidney injuryHigh riskAcute Kidney Injury Network definitionPreoperative brain natriuretic peptide levelsBrain natriuretic peptide levelsSerum brain natriuretic peptideAcute renal replacement therapyAcute Kidney Injury studyDoubling of creatinineHigher AKI riskPreoperative BNP levelsNatriuretic peptide levelsHigh-risk patientsRenal replacement therapyBrain natriuretic peptidePreoperative risk stratificationTypes of patientsAddition of BNPAKI cases
2009
Determinants of Cardiac Catheterization Use in Older Medicare Patients With Acute Myocardial Infarction
Ko DT, Ross JS, Wang Y, Krumholz HM. Determinants of Cardiac Catheterization Use in Older Medicare Patients With Acute Myocardial Infarction. Circulation Cardiovascular Quality And Outcomes 2009, 3: 54-62. PMID: 20123672, PMCID: PMC3024143, DOI: 10.1161/circoutcomes.109.858456.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAged, 80 and overCardiac CatheterizationChi-Square DistributionComorbidityFemaleHemorrhageHospitalizationHumansLikelihood FunctionsLogistic ModelsMaleMedicareMyocardial InfarctionPatient SelectionPractice Patterns, Physicians'Risk AssessmentRisk FactorsSeverity of Illness IndexSex FactorsTime FactorsTreatment OutcomeUnited StatesConceptsAcute myocardial infarctionCardiac catheterization useCardiac catheterizationInappropriate indicationsAMI patientsAppropriate indicationsMyocardial infarctionRisk scoreCardiology/American Heart Association class IBaseline cardiovascular riskOlder Medicare patientsHigh-risk patientsDemographic factorsMore comorbiditiesCardiovascular riskOlder patientsMale sexProcedure indicationFemale sexMedicare patientsAmerican CollegeAMI admissionsMedicare feePatientsCatheterization
2008
Regional Variation in Cardiac Catheterization Appropriateness and Baseline Risk After Acute Myocardial Infarction
Ko DT, Wang Y, Alter DA, Curtis JP, Rathore SS, Stukel TA, Masoudi FA, Ross JS, Foody JM, Krumholz HM. Regional Variation in Cardiac Catheterization Appropriateness and Baseline Risk After Acute Myocardial Infarction. Journal Of The American College Of Cardiology 2008, 51: 716-723. PMID: 18279735, DOI: 10.1016/j.jacc.2007.10.039.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionCardiac catheterization useBaseline riskCardiac catheterizationMyocardial infarctionCardiology/American Heart Association classificationRisk-standardized mortality ratesAmerican Heart Association classificationCardiac catheterization ratesGRACE risk scoreHigh-risk patientsClass I patientsClass III patientsClass II patientsPatient appropriatenessCatheterization ratesHospital admissionI patientsPrimary outcomeAMI patientsII patientsIII patientsAppropriate indicationsInvasive strategyPhysician characteristics
2007
Identifying Heart Failure Patients at High Risk for Near-Term Cardiovascular Events With Serial Health Status Assessments
Kosiborod M, Soto GE, Jones PG, Krumholz HM, Weintraub WS, Deedwania P, Spertus JA. Identifying Heart Failure Patients at High Risk for Near-Term Cardiovascular Events With Serial Health Status Assessments. Circulation 2007, 115: 1975-1981. PMID: 17420346, DOI: 10.1161/circulationaha.106.670901.Peer-Reviewed Original ResearchConceptsKansas City Cardiomyopathy QuestionnaireHeart failure outpatientsHealth status assessmentCause mortalityCardiovascular mortalityKaplan-Meier survival analysisHigh-risk patientsHeart failure patientsAcute myocardial infarctionProportional hazards modelIntensity of treatmentStatus assessmentKCCQ scoresCardiovascular deathCardiovascular eventsClinical deteriorationMultivariable adjustmentFailure patientsHeart failureOutpatient visitsMyocardial infarctionHigh riskHospitalizationPatientsCombined outcome
2000
Predictors of readmission among elderly survivors of admission with heart failure
Krumholz H, Chen Y, Wang Y, Vaccarino V, Radford M, Horwitz R. Predictors of readmission among elderly survivors of admission with heart failure. American Heart Journal 2000, 139: 72-77. PMID: 10618565, DOI: 10.1016/s0002-8703(00)90311-9.Peer-Reviewed Original ResearchConceptsHigh-risk patientsHeart failureRisk predictorsCause readmissionClinical factorsValidation cohortHeart failure-related readmissionsPrior heart failurePatients 65 yearsPredictors of readmissionRisk of readmissionMedical record reviewGroup of patientsPrincipal discharge diagnosisResource-intensive interventionsMedicare administrative databasesCreatinine levelsElderly patientsPrior admissionReadmission ratesDerivation cohortRecord reviewDischarge diagnosisAdministrative databasesConnecticut hospitals
1997
When to start cholesterol-lowering therapy in patients with coronary heart disease. A statement for healthcare professionals from the American Heart Association Task Force on Risk Reduction.
Grundy S, Balady G, Criqui M, Fletcher G, Greenland P, Hiratzka L, Houston-Miller N, Kris-Etherton P, Krumholz H, LaRosa J, Ockene I, Pearson T, Reed J, Smith S, Washington R. When to start cholesterol-lowering therapy in patients with coronary heart disease. A statement for healthcare professionals from the American Heart Association Task Force on Risk Reduction. Circulation 1997, 95: 1683-5. PMID: 9118557, DOI: 10.1161/01.cir.95.6.1683.Peer-Reviewed Original ResearchConceptsCholesterol-lowering therapyAggressive cholesterol-lowering therapyAtherosclerotic diseaseCholesterol loweringAmerican Heart Association Task ForceCholesterol-lowering trialsClinical atherosclerotic diseaseFuture coronary eventsHigh-risk patientsSubstantial clinical benefitMajority of patientsCoronary heart diseaseLDL cholesterol loweringPrimary care physiciansBenefits of therapyRisk-reducing treatmentsNonpharmaceutical approachesRecurrent CHDCoronary eventsCare physiciansClinical benefitCholesterol managementClinical managementHeart diseaseCholesterol reduction