2024
Artificial Intelligence-Enhanced Risk Stratification of Cancer Therapeutics-Related Cardiac Dysfunction Using Electrocardiographic Images.
Oikonomou E, Sangha V, Dhingra L, Aminorroaya A, Coppi A, Krumholz H, Baldassarre L, Khera R. Artificial Intelligence-Enhanced Risk Stratification of Cancer Therapeutics-Related Cardiac Dysfunction Using Electrocardiographic Images. Circulation Cardiovascular Quality And Outcomes 2024 PMID: 39221857, DOI: 10.1161/circoutcomes.124.011504.Peer-Reviewed Original ResearchCancer therapeutics-related cardiac dysfunctionGlobal longitudinal strainLeft ventricular systolic dysfunctionCardiac dysfunctionBreast cancerNon-Hodgkin lymphoma therapyNon-Hodgkin's lymphomaVentricular systolic dysfunctionAssociated with worse global longitudinal strainRisk stratification strategiesHigh-risk groupMonths post-treatmentPost hoc analysisElectrocardiographic (ECGTrastuzumab exposureLymphoma therapySystolic dysfunctionAI-ECGBefore treatmentRisk biomarkersLongitudinal strainLow riskStratification strategiesHigher incidencePositive screen
2008
Long-term Prognosis of Acute Kidney Injury After Acute Myocardial Infarction
Parikh CR, Coca SG, Wang Y, Masoudi FA, Krumholz HM. Long-term Prognosis of Acute Kidney Injury After Acute Myocardial Infarction. JAMA Internal Medicine 2008, 168: 987-995. PMID: 18474763, DOI: 10.1001/archinte.168.9.987.Peer-Reviewed Original ResearchConceptsSevere acute kidney injuryAcute kidney injuryAcute myocardial infarctionMild acute kidney injuryModerate acute kidney injuryKidney injuryLong-term riskMyocardial infarctionSeverity of AKIAdjusted hazard ratioLong-term mortalitySerum creatinine levelsLong-term prognosisCooperative Cardiovascular ProjectElderly Medicare patientsHigh-risk groupAssociation of severityHospital mortalityHospital survivorsCause mortalityCardiovascular mortalityCreatinine levelsHazard ratioInpatient mortalityCommon complication
2006
Depressive Symptoms After Acute Myocardial Infarction: Evidence for Highest Rates in Younger Women
Mallik S, Spertus JA, Reid KJ, Krumholz HM, Rumsfeld JS, Weintraub WS, Agarwal P, Santra M, Bidyasar S, Lichtman JH, Wenger NK, Vaccarino V. Depressive Symptoms After Acute Myocardial Infarction: Evidence for Highest Rates in Younger Women. JAMA Internal Medicine 2006, 166: 876-883. PMID: 16636213, DOI: 10.1001/archinte.166.8.876.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMean PHQ scoreWomen 60 yearsPrevalence of depressionPHQ scoresMyocardial infarctionYoung womenCoronary heart disease risk factorsProspective Registry Evaluating OutcomesHeart disease risk factorsPatient Health Questionnaire scoresPost-AMI depressionPrimary Care EvaluationDisease risk factorsTime of hospitalizationHigh-risk groupOdds of depressionAggressive screeningOlder patientsYounger patientsAMI patientsAdverse outcomesMen 60Medical historyRisk factorsRecursive partitioning–based preoperative risk stratification for atrial fibrillation after coronary artery bypass surgery
Sedrakyan A, Zhang H, Treasure T, Krumholz HM. Recursive partitioning–based preoperative risk stratification for atrial fibrillation after coronary artery bypass surgery. American Heart Journal 2006, 151: 720-724. PMID: 16504639, DOI: 10.1016/j.ahj.2005.05.010.Peer-Reviewed Original ResearchConceptsCoronary artery bypass graft surgeryAtrial fibrillationLow-risk groupAggressive prophylaxisRelative riskPredictors of AFArtery bypass graft surgeryCoronary artery bypass surgeryRisk of AFYale-New Haven HospitalOnly ejection fractionPreoperative atrial fibrillationBypass graft surgeryArtery bypass surgeryCoronary artery diseasePreoperative risk stratificationHigh-risk groupHeart disease severityPossible adverse eventsOlder age subgroupsArrhythmia prophylaxisGraft surgeryProphylactic therapyAdverse eventsBypass surgery
2005
Knowledge of blood pressure levels and targets in patients with coronary artery disease in the USA
Cheng S, Lichtman JH, Amatruda JM, Smith GL, Mattera JA, Roumanis SA, Krumholz HM. Knowledge of blood pressure levels and targets in patients with coronary artery disease in the USA. Journal Of Human Hypertension 2005, 19: 769-774. PMID: 16049521, DOI: 10.1038/sj.jhh.1001895.Peer-Reviewed Original ResearchConceptsBlood pressure levelsCoronary artery diseaseDiastolic blood pressure levelsArtery diseaseImportant modifiable risk factorTarget blood pressure levelsBlood pressure targetsHistory of hypertensionLow-risk patientsModifiable risk factorsCertain patient subgroupsHigh-risk groupBlood pressure knowledgePressure levelsClinical characteristicsPressure targetsRisk patientsPatient subgroupsPatient awarenessRisk factorsRisk groupsCardiac diseasePatientsDiseaseHypertension
2003
Validity of a Simple ST-Elevation Acute Myocardial Infarction Risk Index
Rathore SS, Weinfurt KP, Gross CP, Krumholz HM. Validity of a Simple ST-Elevation Acute Myocardial Infarction Risk Index. Circulation 2003, 107: 811-816. PMID: 12591749, DOI: 10.1161/01.cir.0000049743.45748.02.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCalibrationCohort StudiesElectrocardiographyFemaleHumansInpatientsMaleMyocardial InfarctionMyocardial ReperfusionPredictive Value of TestsPrognosisRandomized Controlled Trials as TopicReproducibility of ResultsRetrospective StudiesRiskRisk AssessmentSurvival AnalysisConceptsSimple risk indexCommunity-based cohortRCT populationMyocardial infarctionST-segment elevation myocardial infarctionST-elevation myocardial infarctionMyocardial Infarction (TIMI) risk indexRandomized clinical trial dataAcute reperfusion therapyPatients 65 yearsRisk stratification scoresElevation myocardial infarctionCommunity-based populationDistribution of patientsHigh-risk groupLow-risk groupRisk stratification indexClinical trial dataYears of ageRisk indexReperfusion therapyRisk score distributionPrognostic scoreMortality estimatesGeneral population
1999
Sex-Based Differences in Early Mortality after Myocardial Infarction
Vaccarino V, Parsons L, Every N, Barron H, Krumholz H. Sex-Based Differences in Early Mortality after Myocardial Infarction. New England Journal Of Medicine 1999, 341: 217-225. PMID: 10413733, DOI: 10.1056/nejm199907223410401.Peer-Reviewed Original ResearchConceptsMyocardial infarctionYears of ageMortality rateSex-based differencesYoung womenMyocardial Infarction 2Odds of deathOverall mortality rateRisk of deathShort-term mortalityHigh-risk groupLogistic regression analysisHigh mortality ratePrognostic factorsEarly mortalityEarly managementMedical historyNational registryClinical severityHigh riskOlder womenInfarctionPatientsHospitalizationWomen