2021
Association between antecedent statin use and decreased mortality in hospitalized patients with COVID-19
Gupta A, Madhavan MV, Poterucha TJ, DeFilippis EM, Hennessey JA, Redfors B, Eckhardt C, Bikdeli B, Platt J, Nalbandian A, Elias P, Cummings MJ, Nouri SN, Lawlor M, Ranard LS, Li J, Boyle C, Givens R, Brodie D, Krumholz HM, Stone GW, Sethi SS, Burkhoff D, Uriel N, Schwartz A, Leon MB, Kirtane AJ, Wan EY, Parikh SA. Association between antecedent statin use and decreased mortality in hospitalized patients with COVID-19. Nature Communications 2021, 12: 1325. PMID: 33637713, PMCID: PMC7910606, DOI: 10.1038/s41467-021-21553-1.Peer-Reviewed Original ResearchConceptsAcute respiratory distress syndromeStatin usePrimary endpointCOVID-19Multivariable logistic regression modelStudy periodLower inpatient mortalityPropensity-matched cohortRespiratory distress syndromeCoronavirus disease 2019Electronic medical recordsLogistic regression modelsPropensity-score matchingHospital mortalityHyperinflammatory stateOutpatient medicationsClinical characteristicsInpatient mortalityStatin usersThrombotic complicationsDistress syndromeHospitalized patientsMyocardial injuryMedical recordsRetrospective analysis
2016
Incidence and Determinants of Traumatic Intracranial Bleeding Among Older Veterans Receiving Warfarin for Atrial Fibrillation
Dodson JA, Petrone A, Gagnon DR, Tinetti ME, Krumholz HM, Gaziano JM. Incidence and Determinants of Traumatic Intracranial Bleeding Among Older Veterans Receiving Warfarin for Atrial Fibrillation. JAMA Cardiology 2016, 1: 65. PMID: 27437657, PMCID: PMC5600874, DOI: 10.1001/jamacardio.2015.0345.Peer-Reviewed Original ResearchConceptsTraumatic intracranial bleedingIntracranial bleedingInternational normalized ratioIschemic strokeAtrial fibrillationIncidence rateAnticonvulsant useWarfarin therapyNormalized ratioRisk factorsOlder adultsVeterans AffairsCox proportional hazards regressionVA electronic medical recordsMean patient agePatients 75 yearsRetrospective cohort studyClinical Modification codesCoronary artery diseaseProportional hazards regressionService claims dataVA administrative dataSignificant predictorsHealth care professionalsElectronic medical records
2005
Validity of Using an Electronic Medical Record for Assessing Quality of Care in an Outpatient Setting
Benin AL, Vitkauskas G, Thornquist E, Shapiro ED, Concato J, Aslan M, Krumholz HM. Validity of Using an Electronic Medical Record for Assessing Quality of Care in an Outpatient Setting. Medical Care 2005, 43: 691-698. PMID: 15970784, DOI: 10.1097/01.mlr.0000167185.26058.8e.Peer-Reviewed Original ResearchConceptsElectronic medical recordsManagement of pharyngitisMedical recordsHealth Plan Employer DataDiagnostic testsEpisode of pharyngitisOutpatient electronic medical recordsProportion of episodesDiagnosis of pharyngitisOutpatient settingTotal episodesPharyngitisEmployer DataElectronic databasesDiagnostic testingClinical encountersMeasures of qualityEpisodesComplete evaluationCareAssessing QualityPediatricsYearsProportionDiagnosis
2003
Improving diagnostic testing and reducing overuse of antibiotics for children with pharyngitis: a useful role for the electronic medical record
BENIN AL, VITKAUSKAS G, THORNQUIST E, SHIFFMAN RN, CONCATO J, KRUMHOLZ HM, SHAPIRO ED. Improving diagnostic testing and reducing overuse of antibiotics for children with pharyngitis: a useful role for the electronic medical record. The Pediatric Infectious Disease Journal 2003, 22: 1043-1047. PMID: 14688562, DOI: 10.1097/01.inf.0000100577.76542.af.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnti-Bacterial AgentsChildChild, PreschoolDiagnostic Tests, RoutineDrug Resistance, MultipleDrug UtilizationElectronic Data ProcessingFemaleHumansLogistic ModelsMalePharyngitisProbabilityRegistriesRetrospective StudiesRisk AssessmentSensitivity and SpecificitySeverity of Illness IndexStatistics, NonparametricConceptsElectronic medical recordsOveruse of antibioticsDiagnostic testingMedical recordsEpisode of pharyngitisPediatric outpatient settingProportion of episodesOutpatient settingAntibiotic useScarlet feverPharyngitisChildren 3Diagnostic testsPatientsAntibioticsAppropriate useCliniciansWeeksEpisodesOveruseUseful rolePrescribingFeverClinicTesting