2024
Factors Associated With Long COVID: Insights From Two Nationwide Surveys
Wu Y, Sawano M, Wu Y, Shah R, Bishop P, Iwasaki A, Krumholz H. Factors Associated With Long COVID: Insights From Two Nationwide Surveys. The American Journal Of Medicine 2024, 137: 515-519. PMID: 38490304, DOI: 10.1016/j.amjmed.2024.02.032.Peer-Reviewed Original ResearchBehavioral Risk Factor Surveillance SystemNational Health Interview SurveyAssociated with long COVIDNational Health Interview Survey cohortRisk Factor Surveillance SystemNon-Hispanic White individualsLong COVIDFactors associated with Long COVIDHealth Interview SurveyCross-sectional studyPositive COVID-19 testNon-HispanicInterview SurveyDoctor's diagnosisWhite individualsCOVID-19 testingCollege degreeCOVID-19 infectionFemale sexSurveillance systemBlack AmericansNationwide surveySeverity of acute COVID-19 infectionAcute COVID-19 infectionCohort
2023
2288. Short and Longer-Term All-Cause Mortality among SARS CoV-2-Infected Persons and the Pull-Forward Phenomenon in Qatar
Chemaitelly H, Faust J, Krumholz H, Ayoub H, Abu-Raddad L. 2288. Short and Longer-Term All-Cause Mortality among SARS CoV-2-Infected Persons and the Pull-Forward Phenomenon in Qatar. Open Forum Infectious Diseases 2023, 10: ofad500.1910. PMCID: PMC10676887, DOI: 10.1093/ofid/ofad500.1910.Peer-Reviewed Original ResearchSevere COVID-19Incidence of deathCause mortalityPrimary infectionCOVID-19Primary SARS-CoV-2 infectionSARS-CoV-2-infected personsCox proportional hazards regression modelSARS-CoV-2 infectionProportional hazards regression modelsPrimary infection cohortRetrospective cohort studyCOVID-19 mortalitySARS-CoV-2Short life expectancyCohort studyHazard ratioUnvaccinated personsMonth 3Uninfected personsVaccinated personsControl cohortNational cohortEarly deathCohortShort- and longer-term all-cause mortality among SARS-CoV-2- infected individuals and the pull-forward phenomenon in Qatar: a national cohort study
Chemaitelly H, Faust J, Krumholz H, Ayoub H, Tang P, Coyle P, Yassine H, Al Thani A, Al-Khatib H, Hasan M, Al-Kanaani Z, Al-Kuwari E, Jeremijenko A, Kaleeckal A, Latif A, Shaik R, Abdul-Rahim H, Nasrallah G, Al-Kuwari M, Butt A, Al-Romaihi H, Al-Thani M, Al-Khal A, Bertollini R, Abu-Raddad L. Short- and longer-term all-cause mortality among SARS-CoV-2- infected individuals and the pull-forward phenomenon in Qatar: a national cohort study. International Journal Of Infectious Diseases 2023, 136: 81-90. PMID: 37717648, DOI: 10.1016/j.ijid.2023.09.005.Peer-Reviewed Original ResearchConceptsAdjusted hazard ratioPrimary infection cohortCause mortalityCohort studyPrimary infectionMortality incidencePrimary SARS-CoV-2 infectionSARS-CoV-2-infected individualsCox proportional hazards regression modelSARS-CoV-2 infectionProportional hazards regression modelsRetrospective cohort studySevere COVID-19Cause mortality riskNational cohort studyCOVID-19 mortalityInfection cohortHazard ratioUnvaccinated personsVaccination statusVaccinated personsMortality riskVulnerable personsAccelerated onsetCohortIn-Hospital Observation on Oral Diuretics After Treatment for Acute Decompensated Heart Failure: Evaluating the Utility
Ivey-Miranda J, Rao V, Cox Z, Moreno-Villagomez J, Mahoney D, Maulion C, Bellumkonda L, Turner J, Collins S, Wilson F, Krumholz H, Testani J. In-Hospital Observation on Oral Diuretics After Treatment for Acute Decompensated Heart Failure: Evaluating the Utility. Circulation Heart Failure 2023, 16: e010206. PMID: 36896716, PMCID: PMC10186250, DOI: 10.1161/circheartfailure.122.010206.Peer-Reviewed Original ResearchConceptsAcute decompensated heart failureDecompensated heart failureDiuretic responseDiuretic dosingOral diureticsHeart failureMulticenter cohortHospital observationLower readmission ratesNet fluid balanceDays postdischargeReadmission ratesHospital readmissionUrine outputReadmission riskFluid statusFluid balanceHospital measuresDose selectionCohortProvider decisionsWeight changeReadmissionDiureticsPatients
2022
Long-Term Stability of Coverage Among Michigan Medicaid Beneficiaries : A Cohort Study.
Ndumele C, Lollo A, Krumholz H, Schlesinger M, Wallace J. Long-Term Stability of Coverage Among Michigan Medicaid Beneficiaries : A Cohort Study. Annals Of Internal Medicine 2022, 176: 22-28. PMID: 36469920, DOI: 10.7326/m22-1313.Peer-Reviewed Original Research
2020
Frequency, trends and institutional variation in 30‐day all‐cause mortality and unplanned readmissions following hospitalisation for heart failure in Australia and New Zealand
Labrosciano C, Horton D, Air T, Tavella R, Beltrame JF, Zeitz CJ, Krumholz HM, Adams R, Scott IA, Gallagher M, Hossain S, Hariharaputhiran S, Ranasinghe I. Frequency, trends and institutional variation in 30‐day all‐cause mortality and unplanned readmissions following hospitalisation for heart failure in Australia and New Zealand. European Journal Of Heart Failure 2020, 23: 31-40. PMID: 33094886, DOI: 10.1002/ejhf.2030.Peer-Reviewed Original ResearchConceptsHF hospitalisationUnplanned readmissionReadmission ratesHeart failure hospitalisationUnplanned readmission rateMortality cohortReadmission cohortCause mortalityHeart failurePrimary outcomeHospitalisationReadmissionSeparate cohortMortality rateHospitalPatientsMortalityCare qualityPrivate hospitalsStudy periodCohortModest declineNational averageOutcomesDays
2019
Noninferiority Designed Cardiovascular Trials in Highest-Impact Journals
Bikdeli B, Welsh JW, Akram Y, Punnanithinont N, Lee I, Desai NR, Kaul S, Stone G, Ross JS, Krumholz HM. Noninferiority Designed Cardiovascular Trials in Highest-Impact Journals. Circulation 2019, 140: 379-389. PMID: 31177811, PMCID: PMC8416048, DOI: 10.1161/circulationaha.119.040214.Peer-Reviewed Original ResearchConceptsNoninferiority marginNoninferiority trialCardiovascular trialsAllocation concealmentLower riskOpen labelHazard ratioRelative riskMethodological qualityProportion of trialsIndependent reviewersRisk differenceNew England JournalNoninferiorityHigh-impact journalsNew interventionsTrialsCohortDiscrepant resultsProtocol analysisTime trendsRiskTreatInterventionFactors
2018
Identifying county characteristics associated with resident well-being: A population based study
Roy B, Riley C, Herrin J, Spatz ES, Arora A, Kell KP, Welsh J, Rula EY, Krumholz HM. Identifying county characteristics associated with resident well-being: A population based study. PLOS ONE 2018, 13: e0196720. PMID: 29791476, PMCID: PMC5965855, DOI: 10.1371/journal.pone.0196720.Peer-Reviewed Original ResearchConceptsCounty-level factorsClinical careCross-sectional studyQuality of lifeBetter health outcomesMulti-dimensional assessmentHealth outcomesBeing IndexGallup-Sharecare WellUS residentsCareCounty characteristicsSurvey participantsResident wellUS countiesScoresCounty equivalentsAssessmentFactorsCohortDefining Multiple Chronic Conditions for Quality Measurement
Drye EE, Altaf FK, Lipska KJ, Spatz ES, Montague JA, Bao H, Parzynski CS, Ross JS, Bernheim SM, Krumholz HM, Lin Z. Defining Multiple Chronic Conditions for Quality Measurement. Medical Care 2018, 56: 193-201. PMID: 29271820, DOI: 10.1097/mlr.0000000000000853.Peer-Reviewed Original ResearchConceptsMultiple chronic conditionsChronic conditionsMedicare feeService beneficiariesMedicare Chronic Conditions WarehouseMCC cohortBroad cohortChronic Conditions WarehouseRisk-standardized ratesNational quality measuresUnplanned admissionsFinal cohortTotal admissionsAdmission riskAccountable care organizationsAdmission ratesOutcome measuresAdmissionCohortCohort conditionCare organizationsPatientsStakeholder inputNarrow cohortBeneficiaries
2017
Two Decades of Cardiovascular Trials With Primary Surrogate Endpoints: 1990–2011
Bikdeli B, Punnanithinont N, Akram Y, Lee I, Desai NR, Ross JS, Krumholz HM. Two Decades of Cardiovascular Trials With Primary Surrogate Endpoints: 1990–2011. Journal Of The American Heart Association 2017, 6: e005285. PMID: 28325713, PMCID: PMC5524035, DOI: 10.1161/jaha.116.005285.Peer-Reviewed Original ResearchConceptsClinical outcome trialsOutcome trialsEndpoint trialsPrimary endpointCardiovascular trialsClinical outcome studiesClinical outcomesSurrogate markerPatient's perspectiveSurrogate endpointsOutcome studiesNew England JournalSample cohortTrial resultsTrialsSurrogate trialsEndpointPositive resultsAmerican MedicalInterventionHigh-impact journalsCohortPrediction of Adverse Events in Patients Undergoing Major Cardiovascular Procedures
Mortazavi B, Desai N, Zhang J, Coppi A, Warner F, Krumholz H, Negahban S. Prediction of Adverse Events in Patients Undergoing Major Cardiovascular Procedures. IEEE Journal Of Biomedical And Health Informatics 2017, 21: 1719-1729. PMID: 28287993, DOI: 10.1109/jbhi.2017.2675340.Peer-Reviewed Original ResearchConceptsMajor cardiovascular proceduresElectronic health recordsRespiratory failureAdverse eventsCardiovascular proceduresYale-New Haven HospitalPostoperative respiratory failurePatient cohortHospital costsPatient outcomesSpecific patientPatientsHealth recordsCohort-specific modelsCharacteristic curveInfectionFailureHospitalCohortClinicians
2015
Trends in Short- and Long-Term Outcomes for Takotsubo Cardiomyopathy Among Medicare Fee-for-Service Beneficiaries, 2007 to 2012
Murugiah K, Wang Y, Desai NR, Spatz ES, Nuti SV, Dreyer RP, Krumholz HM. Trends in Short- and Long-Term Outcomes for Takotsubo Cardiomyopathy Among Medicare Fee-for-Service Beneficiaries, 2007 to 2012. JACC Heart Failure 2015, 4: 197-205. PMID: 26746377, PMCID: PMC5323042, DOI: 10.1016/j.jchf.2015.09.013.Peer-Reviewed Original ResearchConceptsLong-term outcomesReadmission ratesNonwhite patientsHospitalization ratesSecondary diagnosisMedicare feeYears of ageTakotsubo cardiomyopathyWorse outcomesWhite racePatientsService beneficiariesHospitalMortalityTime pointsOutcomesHospitalizationCohortDiagnosisRepresentative dataTakotsuboTTCReadmissionCardiomyopathyYearsInsurance and Prehospital Delay in Patients ≤55 Years With Acute Myocardial Infarction
Chen SI, Wang Y, Dreyer R, Strait KM, Spatz ES, Xu X, Smolderen KG, Desai NR, Lorenze NP, Lichtman JH, Spertus JA, D'Onofrio G, Bueno H, Masoudi FA, Krumholz HM. Insurance and Prehospital Delay in Patients ≤55 Years With Acute Myocardial Infarction. The American Journal Of Cardiology 2015, 116: 1827-1832. PMID: 26541907, PMCID: PMC5323057, DOI: 10.1016/j.amjcard.2015.09.018.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionPrehospital delayInsurance statusMyocardial infarctionSpanish patientsGender differencesHealth care systemUS patientsProspective studyUS cohortUS womenPatientsUniversal insuranceCare systemWomenSignificant gender differencesInfarctionMenInsurance groupsHoursStatusAssociationLarge proportionDifferencesCohort
2012
Correlations among risk‐standardized mortality rates and among risk‐standardized readmission rates within hospitals
Horwitz LI, Wang Y, Desai MM, Curry LA, Bradley EH, Drye EE, Krumholz HM. Correlations among risk‐standardized mortality rates and among risk‐standardized readmission rates within hospitals. Journal Of Hospital Medicine 2012, 7: 690-696. PMID: 22865546, PMCID: PMC3535010, DOI: 10.1002/jhm.1965.Peer-Reviewed Original ResearchConceptsRisk-standardized mortality ratesAcute myocardial infarctionRisk-standardized readmission ratesReadmission ratesRisk-standardized mortalityHeart failureMortality rateReadmission measuresUS hospitalsMortality measuresCross-sectional studyMortality cohortReadmission cohortHospital outcomesSame hospitalMyocardial infarctionMedicare patientsMedicare feeService beneficiariesTeaching hospital membersHospitalSame quartileHospital membersPneumoniaCohort
2009
Elevated Admission Glucose and Mortality in Elderly Patients Hospitalized With Heart Failure
Kosiborod M, Inzucchi SE, Spertus JA, Wang Y, Masoudi FA, Havranek EP, Krumholz HM. Elevated Admission Glucose and Mortality in Elderly Patients Hospitalized With Heart Failure. Circulation 2009, 119: 1899-1907. PMID: 19332465, DOI: 10.1161/circulationaha.108.821843.Peer-Reviewed Original ResearchConceptsHeart failureAdmission glucoseElderly patientsDiabetes mellitusAdverse outcomesMultivariable Cox regression modelsAdmission glucose levelsElevated admission glucoseAcute myocardial infarctionCox regression modelCause mortalityMultivariable adjustmentEntire cohortGlucose controlMyocardial infarctionCardiovascular conditionsGlucose levelsLarge cohortElevated glucoseRepresentative cohortPatientsSignificant associationMortalityCohortMellitus
2007
Impact of Delay in Door-to-Needle Time on Mortality in Patients With ST-Segment Elevation Myocardial Infarction
McNamara RL, Herrin J, Wang Y, Curtis JP, Bradley EH, Magid DJ, Rathore SS, Nallamothu BK, Peterson ED, Blaney ME, Frederick P, Krumholz HM. Impact of Delay in Door-to-Needle Time on Mortality in Patients With ST-Segment Elevation Myocardial Infarction. The American Journal Of Cardiology 2007, 100: 1227-1232. PMID: 17920362, PMCID: PMC2715362, DOI: 10.1016/j.amjcard.2007.05.043.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overArrhythmias, CardiacCaliforniaCohort StudiesEmergency Service, HospitalEmergency TreatmentFemaleFibrinolytic AgentsHospital MortalityHumansMaleMedical RecordsMyocardial InfarctionOutcome Assessment, Health CareRegistriesRetrospective StudiesThrombolytic TherapyTime and Motion StudiesTime FactorsConceptsST-segment elevation myocardial infarctionElevation myocardial infarctionNeedle timeFibrinolytic therapyMyocardial infarctionHospital mortalitySymptom onsetOdds ratioReperfusion strategyAdjunctive medicationsHospital arrivalShorter doorTimely administrationNational registryRepresentative cohortPatientsMortalityInfarctionTherapyIndependent effectsCohortMinutesSmaller centersOnsetImpact of delayAcute Reperfusion Therapy in ST-Elevation Myocardial Infarction from 1994-2003
Nallamothu BK, Blaney ME, Morris SM, Parsons L, Miller DP, Canto JG, Barron HV, Krumholz HM, Investigators R. Acute Reperfusion Therapy in ST-Elevation Myocardial Infarction from 1994-2003. The American Journal Of Medicine 2007, 120: 693.e1-693.e8. PMID: 17679128, PMCID: PMC2020513, DOI: 10.1016/j.amjmed.2007.01.028.Peer-Reviewed Original ResearchConceptsAcute reperfusion therapyST-elevation myocardial infarctionReperfusion therapyMyocardial infarctionIdeal patientPrimary percutaneous coronary interventionPercutaneous coronary interventionNational performance measuresChest painCoronary interventionFibrinolytic therapySymptom onsetNational registryPatientsTherapyInfarctionKey subgroupsAppropriate utilizationTime periodRecent time periodPainRegistryCohortContemporary useImportant opportunity
2005
Performance of the Thrombolysis in Myocardial Infarction (TIMI) ST-elevation myocardial infarction risk score in a national cohort of elderly patients
Rathore SS, Weinfurt KP, Foody JM, Krumholz HM. Performance of the Thrombolysis in Myocardial Infarction (TIMI) ST-elevation myocardial infarction risk score in a national cohort of elderly patients. American Heart Journal 2005, 150: 402-410. PMID: 16169316, PMCID: PMC2790534, DOI: 10.1016/j.ahj.2005.03.069.Peer-Reviewed Original ResearchConceptsThirty-day mortality rateTIMI scoreElderly patientsMortality rateRisk scoreMyocardial Infarction (TIMI) risk scoreHigh TIMI scoreMyocardial Infarction (TIMI) scoreCommunity-based cohortReperfusion therapyTrial cohortPrognostic discriminationTrial populationNational cohortModest discriminationPatientsUS hospitalsSTEMICohortScore discriminationScoresThrombolysis
2003
Left ventricular systolic function and survival in a contemporary cohort of patients with heart failure
Masoudi F, Wolfe P, Rathore S, Foody J, Ordin D, Krumholz H, Havranek E. Left ventricular systolic function and survival in a contemporary cohort of patients with heart failure. Journal Of The American College Of Cardiology 2003, 41: 147-148. DOI: 10.1016/s0735-1097(03)80852-5.Peer-Reviewed Original ResearchA Critical Evaluation of Critical Pathways in Head and Neck Cancer
Yueh B, Weaver EM, Bradley EH, Krumholz HM, Heagerty P, Conley A, Sasaki CT. A Critical Evaluation of Critical Pathways in Head and Neck Cancer. JAMA Otolaryngology - Head & Neck Surgery 2003, 129: 89-95. PMID: 12525201, DOI: 10.1001/archotol.129.1.89.Peer-Reviewed Original ResearchConceptsNeck cancerCritical pathwaysLaryngectomy patientsManagement of headLow-volume proceduresLinear spline regression modelsPathway adoptionObservational cohortPathway patientsContemporary cohortHistorical cohortPathway implementationMedical CenterSpline regression modelsConfounding variablesLaryngectomyPatientsUtilization trendsCohortPrior reportsIndependent impactLOSSignificant differencesCancer