2021
The Type II Anti‐CD20 Antibody Obinutuzumab (GA101) Is More Effective Than Rituximab at Depleting B Cells and Treating Disease in a Murine Lupus Model
Marinov A, Wang H, Bastacky S, van Puijenbroek E, Schindler T, Speziale D, Perro M, Klein C, Nickerson K, Shlomchik M. The Type II Anti‐CD20 Antibody Obinutuzumab (GA101) Is More Effective Than Rituximab at Depleting B Cells and Treating Disease in a Murine Lupus Model. Arthritis & Rheumatology 2021, 73: 826-836. PMID: 33277983, PMCID: PMC8084886, DOI: 10.1002/art.41608.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, Monoclonal, HumanizedB-LymphocytesFlow CytometryImmunologic FactorsKidneyLupus Erythematosus, SystemicLymphocyte DepletionMiceMice, Inbred MRL lprRituximabSkinConceptsMRL/lpr miceB-cell depletionSystemic lupus erythematosusDiseased MRL/lpr miceLpr miceB cellsCell depletionEarly diseaseLupus-prone MRL/lpr micePathogenic B cellsAnti-CD20 antibodyClinical end pointsCD20 monoclonal antibodyMurine lupus modelsMultiple clinical end pointsAmelioration of diseaseAdvanced disease modelsAdvanced diseaseAutoantibody titersLupus nephritisLupus modelsLupus erythematosusInflammatory settingsSingle doseCD20 mAbs
2014
Activation of Rheumatoid Factor–Specific B Cells Is Antigen Dependent and Occurs Preferentially Outside of Germinal Centers in the Lupus-Prone NZM2410 Mouse Model
Sang A, Niu H, Cullen J, Choi SC, Zheng YY, Wang H, Shlomchik MJ, Morel L. Activation of Rheumatoid Factor–Specific B Cells Is Antigen Dependent and Occurs Preferentially Outside of Germinal Centers in the Lupus-Prone NZM2410 Mouse Model. The Journal Of Immunology 2014, 193: 1609-1621. PMID: 25015835, PMCID: PMC4119566, DOI: 10.4049/jimmunol.1303000.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoantibodiesAutoantigensB-LymphocytesCell DifferentiationCells, CulturedChromatinDisease Models, AnimalFemaleGerminal CenterImmune ToleranceImmunoglobulin GLupus Erythematosus, SystemicLymphocyte ActivationMiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutReceptors, Antigen, B-CellRheumatoid FactorToll-Like Receptor 7Toll-Like Receptor 9ConceptsRF B cellsAb-forming cellsB cellsImmune complexesGerminal centersMouse modelMRL/lpr strainMRL/lpr miceLupus-prone mouse modelsH chain transgenic miceRheumatoid factor B cellsTLR9-dependent mannerH chain transgeneIC immunizationC57BL/6 controlsLpr miceLupus-proneTLR9 pathwayLPR strainAntigen DependentTransgenic miceGenetic background