High affinity rheumatoid factor transgenic B cells are eliminated in normal mice.
Wang H, Shlomchik M. High affinity rheumatoid factor transgenic B cells are eliminated in normal mice. The Journal Of Immunology 1997, 159: 1125-34. PMID: 9233605, DOI: 10.4049/jimmunol.159.3.1125.Peer-Reviewed Original ResearchConceptsRF B cellsRheumatoid factorB cell toleranceB cellsNormal miceCell toleranceTransgenic modelMRL/lpr miceAutoimmune MRL/lpr miceDisease-related specificitySystemic autoimmune diseaseTransgenic B cellsAutoimmune animalsAutoimmune inductionAutoimmune syndromeMultiple autoantibodiesRheumatoid arthritisLpr miceSerum IgGTolerance inductionAutoimmune diseasesCentral toleranceCognate AgNegative miceNormal animals