2014
Activation of Rheumatoid Factor–Specific B Cells Is Antigen Dependent and Occurs Preferentially Outside of Germinal Centers in the Lupus-Prone NZM2410 Mouse Model
Sang A, Niu H, Cullen J, Choi SC, Zheng YY, Wang H, Shlomchik MJ, Morel L. Activation of Rheumatoid Factor–Specific B Cells Is Antigen Dependent and Occurs Preferentially Outside of Germinal Centers in the Lupus-Prone NZM2410 Mouse Model. The Journal Of Immunology 2014, 193: 1609-1621. PMID: 25015835, PMCID: PMC4119566, DOI: 10.4049/jimmunol.1303000.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoantibodiesAutoantigensB-LymphocytesCell DifferentiationCells, CulturedChromatinDisease Models, AnimalFemaleGerminal CenterImmune ToleranceImmunoglobulin GLupus Erythematosus, SystemicLymphocyte ActivationMiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutReceptors, Antigen, B-CellRheumatoid FactorToll-Like Receptor 7Toll-Like Receptor 9ConceptsRF B cellsAb-forming cellsB cellsImmune complexesGerminal centersMouse modelMRL/lpr strainMRL/lpr miceLupus-prone mouse modelsH chain transgenic miceRheumatoid factor B cellsTLR9-dependent mannerH chain transgeneIC immunizationC57BL/6 controlsLpr miceLupus-proneTLR9 pathwayLPR strainAntigen DependentTransgenic miceGenetic background
1997
High affinity rheumatoid factor transgenic B cells are eliminated in normal mice.
Wang H, Shlomchik M. High affinity rheumatoid factor transgenic B cells are eliminated in normal mice. The Journal Of Immunology 1997, 159: 1125-34. PMID: 9233605, DOI: 10.4049/jimmunol.159.3.1125.Peer-Reviewed Original ResearchConceptsRF B cellsRheumatoid factorB cell toleranceB cellsNormal miceCell toleranceTransgenic modelMRL/lpr miceAutoimmune MRL/lpr miceDisease-related specificitySystemic autoimmune diseaseTransgenic B cellsAutoimmune animalsAutoimmune inductionAutoimmune syndromeMultiple autoantibodiesRheumatoid arthritisLpr miceSerum IgGTolerance inductionAutoimmune diseasesCentral toleranceCognate AgNegative miceNormal animals