Maternal Ig mediates neonatal tolerance in rheumatoid factor transgenic mice but tolerance breaks down in adult mice.
Wang H, Shlomchik M. Maternal Ig mediates neonatal tolerance in rheumatoid factor transgenic mice but tolerance breaks down in adult mice. The Journal Of Immunology 1998, 160: 2263-71. PMID: 9498766, DOI: 10.4049/jimmunol.160.5.2263.Peer-Reviewed Original ResearchConceptsTransgenic miceDegree of autoreactivityRF B cellsChronic autoimmune diseaseT cell toleranceB cell deletionSelf-reactive cellsAutoimmune animalsNeonatal toleranceMaternal IgGMaternal IgTolerance breakAutoimmune diseasesB lineage cellsYoung miceNormal miceAdult miceB cellsBone marrowCell toleranceMiceLineage cellsCell deletionWk postweaningSustained expression