2016
PTPN22 inhibition resets defective human central B cell tolerance
Schickel JN, Kuhny M, Baldo A, Bannock JM, Massad C, Wang H, Katz N, Oe T, Menard L, Soulas-Sprauel P, Strowig T, Flavell R, Meffre E. PTPN22 inhibition resets defective human central B cell tolerance. Science Immunology 2016, 1 PMID: 27917411, PMCID: PMC5127630, DOI: 10.1126/sciimmunol.aaf7153.Peer-Reviewed Original Research
1999
Regulation of autoreactive anti-IgG (Rheumatoid Factor) B cells in normal and autoimmune mice
Wang H, Shlomchik M. Regulation of autoreactive anti-IgG (Rheumatoid Factor) B cells in normal and autoimmune mice. Immunologic Research 1999, 19: 259-270. PMID: 10493179, DOI: 10.1007/bf02786493.Peer-Reviewed Original ResearchConceptsB cellsNormal miceAutoimmune miceAutoimmune diseasesMRL/lpr/lpr miceLpr/lpr miceAutoimmune prone animalsRF B cellsChronic autoimmune diseaseSystemic autoimmune diseaseAntigen-specific mannerAutoreactive B cellsParticular underlying diseaseAutoimmune animalsRF autoantibodiesUnderlying diseaseMaternal IgGLpr miceYoung miceTransgenic miceMiceDiseaseAutoantigensRF clonesCells
1998
Maternal Ig mediates neonatal tolerance in rheumatoid factor transgenic mice but tolerance breaks down in adult mice.
Wang H, Shlomchik M. Maternal Ig mediates neonatal tolerance in rheumatoid factor transgenic mice but tolerance breaks down in adult mice. The Journal Of Immunology 1998, 160: 2263-71. PMID: 9498766, DOI: 10.4049/jimmunol.160.5.2263.Peer-Reviewed Original ResearchConceptsTransgenic miceDegree of autoreactivityRF B cellsChronic autoimmune diseaseT cell toleranceB cell deletionSelf-reactive cellsAutoimmune animalsNeonatal toleranceMaternal IgGMaternal IgTolerance breakAutoimmune diseasesB lineage cellsYoung miceNormal miceAdult miceB cellsBone marrowCell toleranceMiceLineage cellsCell deletionWk postweaningSustained expression
1997
High affinity rheumatoid factor transgenic B cells are eliminated in normal mice.
Wang H, Shlomchik M. High affinity rheumatoid factor transgenic B cells are eliminated in normal mice. The Journal Of Immunology 1997, 159: 1125-34. PMID: 9233605, DOI: 10.4049/jimmunol.159.3.1125.Peer-Reviewed Original ResearchConceptsRF B cellsRheumatoid factorB cell toleranceB cellsNormal miceCell toleranceTransgenic modelMRL/lpr miceAutoimmune MRL/lpr miceDisease-related specificitySystemic autoimmune diseaseTransgenic B cellsAutoimmune animalsAutoimmune inductionAutoimmune syndromeMultiple autoantibodiesRheumatoid arthritisLpr miceSerum IgGTolerance inductionAutoimmune diseasesCentral toleranceCognate AgNegative miceNormal animals