Functional connectome-wide associations of schizophrenia polygenic risk
Cao H, Zhou H, Cannon TD. Functional connectome-wide associations of schizophrenia polygenic risk. Molecular Psychiatry 2020, 26: 2553-2561. PMID: 32127647, PMCID: PMC9557214, DOI: 10.1038/s41380-020-0699-3.Peer-Reviewed Original ResearchConceptsSchizophrenia polygenic riskLarge-scale brain networksGeneral cognitive abilityDefault mode systemHigher schizophrenia polygenic risk scoresIndividual's genetic liabilityHuman Connectome ProjectLower functional connectivityPolygenic riskFrontoparietal systemCognitive abilitiesFMRI paradigmNeural mechanismsSchizophrenia polygenic risk scoresBrain networksFunctional connectivityFMRI dataHeritable mental disorderConnectome ProjectVisual systemNeuropsychiatric PhenomicsFunctional dysconnectivityGenetic liabilityMental disordersSchizophreniaPhenome-wide Association Analysis of Substance Use Disorders in a Deeply Phenotyped Sample
Kember RL, Hartwell EE, Xu H, Rotenberg J, Almasy L, Zhou H, Gelernter J, Kranzler HR. Phenome-wide Association Analysis of Substance Use Disorders in a Deeply Phenotyped Sample. Biological Psychiatry 2022, 93: 536-545. PMID: 36273948, PMCID: PMC9931661, DOI: 10.1016/j.biopsych.2022.08.010.Peer-Reviewed Original ResearchConceptsSubstance use disordersAlcohol use disorderOpioid use disorderPolygenic risk scoresUse disordersCo-occurring psychiatric disordersComprehensive psychiatric interviewSemi-Structured AssessmentElectronic health recordsControl subjectsLow prevalencePsychiatric interviewRisk scorePsychiatric disordersPhenome-wide association analysisDrug dependenceEuropean individualsHealth recordsLifetime cannabisPhenome-wide association studyDisordersAfrican ancestry individualsDSM diagnosesPopulation sampleGenetic liability