2023
Predictive Power of Interictal Epileptiform Discharges in Fitness-to-Drive Evaluation
Krestel H, Schreier D, Sakiri E, von Allmen A, Abukhadra Y, Nirkko A, Steinlin M, Rosenow F, Markhus R, Schneider G, Jagella C, Mathis J, Blumenfeld H. Predictive Power of Interictal Epileptiform Discharges in Fitness-to-Drive Evaluation. Neurology 2023, 101: e866-e878. PMID: 37414567, PMCID: PMC10501101, DOI: 10.1212/wnl.0000000000207531.Peer-Reviewed Original ResearchDecreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures
McCafferty C, Gruenbaum B, Tung R, Li J, Zheng X, Salvino P, Vincent P, Kratochvil Z, Ryu J, Khalaf A, Swift K, Akbari R, Islam W, Antwi P, Johnson E, Vitkovskiy P, Sampognaro J, Freedman I, Kundishora A, Depaulis A, David F, Crunelli V, Sanganahalli B, Herman P, Hyder F, Blumenfeld H. Decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures. Nature Communications 2023, 14: 117. PMID: 36627270, PMCID: PMC9832004, DOI: 10.1038/s41467-022-35535-4.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCerebral CortexConsciousnessElectroencephalographyEpilepsy, AbsenceFemaleHumansNeuronsRatsRodentiaSeizuresThalamusConceptsThalamic neuronsAbsence seizuresSeizure onsetNeuronal firingConsciousness-impairing seizuresFemale rat modelLow-frequency electroencephalographic activityFunctional magnetic resonanceBehavioral arrestRat modelRhythmic firingTransient initial peakFiring increasesSeizuresNeuronal mechanismsElectroencephalographic activityNeuronsBrain state changesBrief episodesFiring decreasesInitial peakFiringMagnetic resonanceDistinct patternsOnset
2022
Distinct signatures of loss of consciousness in focal impaired awareness versus tonic-clonic seizures
Juan E, Górska U, Kozma C, Papantonatos C, Bugnon T, Denis C, Kremen V, Worrell G, Struck A, Bateman L, Merricks E, Blumenfeld H, Tononi G, Schevon C, Boly M. Distinct signatures of loss of consciousness in focal impaired awareness versus tonic-clonic seizures. Brain 2022, 146: 109-123. PMID: 36383415, PMCID: PMC10582624, DOI: 10.1093/brain/awac291.Peer-Reviewed Original ResearchConceptsBilateral tonic-clonic seizuresFocal impaired awarenessTonic-clonic seizuresLoss of consciousnessSeizure onset zoneSlow wave activityIntracranial EEG activityImpaired awarenessIctal recruitmentCortical activationOnset zoneHigh-gamma activityCross-frequency couplingFocal impaired awareness seizuresNegative prognostic consequencesSleep-like activityEEG activityCortical firing ratesParieto-occipital cortexPosterior brain regionsMulti-unit activityAwareness seizuresClinical outcomesPrognostic consequencesClinical signsQuantitative epileptiform burden and electroencephalography background features predict post-traumatic epilepsy
Chen Y, Li S, Ge W, Jing J, Chen HY, Doherty D, Herman A, Kaleem S, Ding K, Osman G, Swisher CB, Smith C, Maciel CB, Alkhachroum A, Lee JW, Dhakar MB, Gilmore EJ, Sivaraju A, Hirsch LJ, Omay SB, Blumenfeld H, Sheth KN, Struck AF, Edlow BL, Westover MB, Kim JA. Quantitative epileptiform burden and electroencephalography background features predict post-traumatic epilepsy. Journal Of Neurology Neurosurgery & Psychiatry 2022, 94: 245-249. PMID: 36241423, PMCID: PMC9931627, DOI: 10.1136/jnnp-2022-329542.Peer-Reviewed Original ResearchMeSH KeywordsBrain Injuries, TraumaticCase-Control StudiesElectroencephalographyEpilepsy, Post-TraumaticHumansRetrospective StudiesConceptsPost-traumatic epilepsyTraumatic brain injuryCT abnormalitiesElectroencephalography featuresAdmission Glasgow Coma Scale scoreGlasgow Coma Scale scoreRetrospective case-control studyMultivariable logistic regression analysisRisk stratification modelCase-control studyLogistic regression analysisTBI admissionsSevere complicationsFuture trialsBrain injuryCT reportsSeizure diagnosisPredictive valueScale scorePatientsLogistic regressionStratification modelQuantitative electroencephalogramTBI mechanismsRegression analysisEvaluating consciousness and awareness during focal seizures: responsiveness testing versus recall testing
Ramirez V, Litvinov B, Gunawardane NA, Zhao CW, Yotter C, Quraishi IH, Blumenfeld H. Evaluating consciousness and awareness during focal seizures: responsiveness testing versus recall testing. Epileptic Disorders 2022, 24: 899-905. PMID: 35904040, PMCID: PMC10042123, DOI: 10.1684/epd.2022.1472.Peer-Reviewed Original ResearchMeSH KeywordsConsciousnessElectroencephalographyEpilepsies, PartialEpilepsyHumansRetrospective StudiesSeizuresConceptsFocal seizuresResponsiveness testingCurrent International LeagueClinical practice settingEEG-video monitoringEpilepsy monitoring unitImportant clinical settingsEpilepsy guidelinesPatient groupFocal epilepsyIctal eventsClinical careInternational LeagueSeizuresPatientsClinical settingPractice settingsClassification guidelinesFurther studiesEpilepsyResponsivenessRecall of experiencesPreliminary findingsRecall testingSettingMore than a feeling: Scalp EEG and eye signals in conscious tactile perception
Gusso MM, Christison-Lagay KL, Zuckerman D, Chandrasekaran G, Kronemer SI, Ding JZ, Freedman NC, Nohama P, Blumenfeld H. More than a feeling: Scalp EEG and eye signals in conscious tactile perception. Consciousness And Cognition 2022, 105: 103411. PMID: 36156359, DOI: 10.1016/j.concog.2022.103411.Peer-Reviewed Original ResearchConceptsEye metricsHigh-density scalp EEGConscious tactile perceptionPerception taskReport taskNeural basisConscious perceptionPhysiological arousalVisual stimuliMicrosaccade rateTactile perceptionTactile stimuliScalp EEGSensory perceptionP300 eventEye signalsPerceptionPresent behaviorPupil diameterStimuliTaskEmpirical studyEEGConsciousnessNeuroscienceA machine‐learning approach for predicting impaired consciousness in absence epilepsy
Springer M, Khalaf A, Vincent P, Ryu JH, Abukhadra Y, Beniczky S, Glauser T, Krestel H, Blumenfeld H. A machine‐learning approach for predicting impaired consciousness in absence epilepsy. Annals Of Clinical And Translational Neurology 2022, 9: 1538-1550. PMID: 36114696, PMCID: PMC9539371, DOI: 10.1002/acn3.51647.Peer-Reviewed Original ResearchSeizure semiology: ILAE glossary of terms and their significance
Beniczky S, Tatum WO, Blumenfeld H, Stefan H, Mani J, Maillard L, Fahoum F, Vinayan KP, Mayor LC, Vlachou M, Seeck M, Ryvlin P, Kahane P. Seizure semiology: ILAE glossary of terms and their significance. Epileptic Disorders 2022, 24: 447-495. PMID: 35770761, DOI: 10.1684/epd.2022.1430.Peer-Reviewed Original ResearchConceptsFocal seizuresFactors Predicting Outcome After Intracranial EEG Evaluation in Patients With Medically Refractory Epilepsy
Sivaraju A, Hirsch L, Gaspard N, Farooque P, Gerrard J, Xu Y, Deng Y, Damisah E, Blumenfeld H, Spencer DD. Factors Predicting Outcome After Intracranial EEG Evaluation in Patients With Medically Refractory Epilepsy. Neurology 2022, 99: e1-e10. PMID: 35508395, PMCID: PMC9259091, DOI: 10.1212/wnl.0000000000200569.Peer-Reviewed Original ResearchMeSH KeywordsDrug Resistant EpilepsyElectrocorticographyElectroencephalographyHumansMagnetic Resonance ImagingRetrospective StudiesTreatment OutcomeConceptsTemporal lobe onsetSeizure freedomResective surgeryIndependent predictorsLesional MRIUnfavorable predictorRefractory epilepsyContinued medical treatmentEpilepsy surgical evaluationFactors Predicting OutcomeIntracranial EEG evaluationNonlesional extratemporal epilepsySubsequent seizure freedomSustained seizure freedomThorough presurgical evaluationSeizure-free outcomeClass II evidenceMedically Refractory EpilepsyRetrospective chart reviewKaplan-Meier curvesSelect clinical scenariosMultivariable regression analysisBest multivariable modelIntracranial EEGSeizure onset localization
2019
Realistic driving simulation during generalized epileptiform discharges to identify electroencephalographic features related to motor vehicle safety: Feasibility and pilot study
Cohen E, Antwi P, Banz BC, Vincent P, Saha R, Arencibia CA, Ryu JH, Atac E, Saleem N, Tomatsu S, Swift K, Hu C, Krestel H, Farooque P, Levy S, Wu J, Crowley M, Vaca FE, Blumenfeld H. Realistic driving simulation during generalized epileptiform discharges to identify electroencephalographic features related to motor vehicle safety: Feasibility and pilot study. Epilepsia 2019, 61: 19-28. PMID: 31646628, PMCID: PMC7424790, DOI: 10.1111/epi.16356.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAutomobile DrivingElectroencephalographyFeasibility StudiesFemaleHumansMalePilot ProjectsSeizuresSimulation TrainingYoung AdultConceptsEpileptiform dischargesGeneralized epileptiform dischargesEEG amplitudeClinical seizuresElectroencephalographic featuresGeneralized epilepsyLarger sample sizeDriving impairmentClinical accompanimentBaseline testingPilot studyMotor vehicle safetyLonger durationSimultaneous EEGSeizuresVisual stimuliEEGSubjectsStimuliRiskSafetyDurationSample sizeResponseEpilepsy
2017
A Switch and Wave of Neuronal Activity in the Cerebral Cortex During the First Second of Conscious Perception
Herman WX, Smith RE, Kronemer SI, Watsky RE, Chen WC, Gober LM, Touloumes GJ, Khosla M, Raja A, Horien CL, Morse EC, Botta KL, Hirsch LJ, Alkawadri R, Gerrard JL, Spencer DD, Blumenfeld H. A Switch and Wave of Neuronal Activity in the Cerebral Cortex During the First Second of Conscious Perception. Cerebral Cortex 2017, 29: 461-474. PMID: 29194517, PMCID: PMC6319177, DOI: 10.1093/cercor/bhx327.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrain MappingCerebral CortexConsciousnessElectroencephalographyFemaleGamma RhythmHumansMaleNeuronsPhotic StimulationReaction TimeVisual PerceptionConceptsCerebral cortexVisual cortexHuman cerebral cortexDirect electrical recordingHz gamma powerDefault mode networkConscious perceptionNeuronal activityAssociation cortexBrain disordersIntracranial electrodesCortexMonophasic wavesMode networkCortex networkGamma powerGamma activationVisual thresholdFirst secondElectrical recordingsStimulus processingInitial activationStimuliActivationFindings
2016
Impaired consciousness in patients with absence seizures investigated by functional MRI, EEG, and behavioural measures: a cross-sectional study
Guo JN, Kim R, Chen Y, Negishi M, Jhun S, Weiss S, Ryu JH, Bai X, Xiao W, Feeney E, Rodriguez-Fernandez J, Mistry H, Crunelli V, Crowley MJ, Mayes LC, Constable RT, Blumenfeld H. Impaired consciousness in patients with absence seizures investigated by functional MRI, EEG, and behavioural measures: a cross-sectional study. The Lancet Neurology 2016, 15: 1336-1345. PMID: 27839650, PMCID: PMC5504428, DOI: 10.1016/s1474-4422(16)30295-2.Peer-Reviewed Original ResearchConceptsAbsence seizuresCross-sectional studyFMRI amplitudeFunctional MRIBehavioral impairmentsJuvenile absence epilepsyBilateral spike-wave dischargesOnset of seizuresPediatric neurology practiceNational InstituteSpike-wave dischargesPhysiological changesBehavioral responsesDefault mode networkImpaired task performanceSeizure durationImpaired consciousnessElectroencephalography changesNeurology practiceAbsence epilepsyFMRI changesBehavioral deficitsMAIN OUTCOMEBehavioral testingEEG changes
2012
Impaired consciousness in epilepsy
Blumenfeld H. Impaired consciousness in epilepsy. The Lancet Neurology 2012, 11: 814-826. PMID: 22898735, PMCID: PMC3732214, DOI: 10.1016/s1474-4422(12)70188-6.Peer-Reviewed Original ResearchMeSH KeywordsCerebral CortexConsciousnessConsciousness DisordersElectroencephalographyEpilepsyHumansNeuroimagingConceptsConsciousness systemQuality of lifeImpaired consciousnessEmotional healthDiverse seizure typesNormal human lifeComplex partial seizuresImpairment of consciousnessImproved treatment strategiesBehavioral testingBrain dysfunctionPartial seizuresSeizure typesTreatment strategiesEpileptic seizuresConsciousnessEpilepsySeizuresHuge consequencesNeuroimagingAlertnessAnatomical structuresSame setImpairmentLife
2011
Where fMRI and Electrophysiology Agree to Disagree: Corticothalamic and Striatal Activity Patterns in the WAG/Rij Rat
Mishra AM, Ellens DJ, Schridde U, Motelow JE, Purcaro MJ, DeSalvo MN, Enev M, Sanganahalli BG, Hyder F, Blumenfeld H. Where fMRI and Electrophysiology Agree to Disagree: Corticothalamic and Striatal Activity Patterns in the WAG/Rij Rat. Journal Of Neuroscience 2011, 31: 15053-15064. PMID: 22016539, PMCID: PMC3432284, DOI: 10.1523/jneurosci.0101-11.2011.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainBrain MappingBrain WavesCerebral CortexCerebrovascular CirculationCorpus StriatumDisease Models, AnimalElectroencephalographyElectrophysiologyEpilepsyImage Processing, Computer-AssistedLaser-Doppler FlowmetryMagnetic Resonance ImagingNicotinic AntagonistsOxygenRatsRats, WistarThalamusTubocurarineVibrissaeConceptsCerebral blood flowCerebral blood volumeLocal field potentialsNeuronal activityLaser Doppler cerebral blood flowSubcortical structuresWAG/Rij ratsNeuronal activity decreasesHuman absence epilepsySpike-wave dischargesWAG/RijMultiunit activity recordingsFMRI signalsFunctional magnetic resonance imaging (fMRI) signalsMagnetic resonance imaging signalsFMRI decreasesCBF decreaseHemodynamic changesCerebral cortexBasal gangliaSomatosensory cortexAbsence epilepsyWhisker stimulationBlood flowAnimal models
2010
Impaired consciousness in temporal lobe seizures: role of cortical slow activity
Englot DJ, Yang L, Hamid H, Danielson N, Bai X, Marfeo A, Yu L, Gordon A, Purcaro MJ, Motelow JE, Agarwal R, Ellens DJ, Golomb JD, Shamy MC, Zhang H, Carlson C, Doyle W, Devinsky O, Vives K, Spencer DD, Spencer SS, Schevon C, Zaveri HP, Blumenfeld H. Impaired consciousness in temporal lobe seizures: role of cortical slow activity. Brain 2010, 133: 3764-3777. PMID: 21081551, PMCID: PMC2995886, DOI: 10.1093/brain/awq316.Peer-Reviewed Original ResearchConceptsTemporal lobe seizuresSlow wave activityTemporal lobe epilepsySimple partial seizuresSubcortical arousal systemsImpaired consciousnessSeizure activityTemporal lobeLobe epilepsyArousal systemCortical functionFocal temporal lobe seizuresHz slow wave activityMesial temporal lobe epilepsyCortical slow activityDepressed cortical functionNetwork inhibition hypothesisTemporal lobe disordersComplex partial seizuresBilateral temporal lobesLanguage-dominant temporal lobeSlow wavesCortical-subcortical networksPowerful inhibitory effectIntracranial electroencephalography recordingsDynamic Time Course of Typical Childhood Absence Seizures: EEG, Behavior, and Functional Magnetic Resonance Imaging
Bai X, Vestal M, Berman R, Negishi M, Spann M, Vega C, Desalvo M, Novotny EJ, Constable RT, Blumenfeld H. Dynamic Time Course of Typical Childhood Absence Seizures: EEG, Behavior, and Functional Magnetic Resonance Imaging. Journal Of Neuroscience 2010, 30: 5884-5893. PMID: 20427649, PMCID: PMC2946206, DOI: 10.1523/jneurosci.5101-09.2010.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBrainBrain MappingCerebrovascular CirculationChildElectroencephalographyEpilepsy, AbsenceFemaleHumansLinear ModelsMagnetic Resonance ImagingMaleModels, NeurologicalMotor ActivityNeuropsychological TestsPsychomotor PerformanceSeizuresSignal Processing, Computer-AssistedTime FactorsConceptsTypical childhood absence seizuresChildhood absence seizuresAbsence seizuresFMRI decreasesSeizure onsetHz spike-wave dischargesMagnetic resonance imaging changesFunctional magnetic resonance imaging (fMRI) changesTime courseHz generalized spikeSpike-wave dischargesFunctional magnetic resonance imagingMagnetic resonance imagingRepetitive tapping taskLateral parietal cortexLateral frontal cortexImpaired consciousnessPediatric patientsImaging changesEEG time-frequency analysisSeizure endMean durationSeizure initiationGeneralized spikeFMRI changes