2020
Thalamic Stimulation Improves Postictal Cortical Arousal and Behavior
Xu J, Galardi MM, Pok B, Patel KK, Zhao CW, Andrews JP, Singla S, McCafferty CP, Feng L, Musonza ET, Kundishora AJ, Gummadavelli A, Gerrard JL, Laubach M, Schiff ND, Blumenfeld H. Thalamic Stimulation Improves Postictal Cortical Arousal and Behavior. Journal Of Neuroscience 2020, 40: 7343-7354. PMID: 32826310, PMCID: PMC7534908, DOI: 10.1523/jneurosci.1370-20.2020.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArousalAvoidance LearningCerebral CortexDeep Brain StimulationFemaleRatsRats, Sprague-DawleyRewardSeizuresThalamusConceptsDeep brain stimulationCentral lateral nucleusBilateral deep brain stimulationCortical slow-wave activityPostictal stateSlow wave activityPostictal periodImpaired consciousnessRefractory epilepsyLateral nucleusBrain stimulationNatural slow-wave sleepModest behavioral improvementCortical slow wavesNovel therapeutic strategiesSlow-wave sleepDisorders of consciousnessBehavioral tasksDepressed consciousnessDBS treatmentThalamic stimulationElectrical hippocampal stimulationFemale ratsHigh success rateRat model
2016
Restoring Conscious Arousal During Focal Limbic Seizures with Deep Brain Stimulation
Kundishora AJ, Gummadavelli A, Ma C, Liu M, McCafferty C, Schiff ND, Willie JT, Gross RE, Gerrard J, Blumenfeld H. Restoring Conscious Arousal During Focal Limbic Seizures with Deep Brain Stimulation. Cerebral Cortex 2016, 27: 1964-1975. PMID: 26941379, PMCID: PMC5964488, DOI: 10.1093/cercor/bhw035.Peer-Reviewed Original ResearchConceptsFocal limbic seizuresDeep brain stimulationLimbic seizuresBrain stimulationImpaired consciousnessNetwork inhibition hypothesisRisk of mortalityNovel therapeutic approachesDual-site stimulationCentral lateral nucleusDisorders of consciousnessQuality of lifeFocal limbicSurgical therapyRefractory epilepsyFocal seizuresNucleus oralisBilateral stimulationIntralaminar thalamusRat modelTherapeutic approachesLateral nucleusBehavioral arousalConscious arousalResponsive neurostimulation