2023
Mapping Lesion-Related Epilepsy to a Human Brain Network
Schaper F, Nordberg J, Cohen A, Lin C, Hsu J, Horn A, Ferguson M, Siddiqi S, Drew W, Soussand L, Winkler A, Simó M, Bruna J, Rheims S, Guenot M, Bucci M, Nummenmaa L, Staals J, Colon A, Ackermans L, Bubrick E, Peters J, Wu O, Rost N, Grafman J, Blumenfeld H, Temel Y, Rouhl R, Joutsa J, Fox M. Mapping Lesion-Related Epilepsy to a Human Brain Network. JAMA Neurology 2023, 80: 891-902. PMID: 37399040, PMCID: PMC10318550, DOI: 10.1001/jamaneurol.2023.1988.Peer-Reviewed Original ResearchConceptsRisk of epilepsyLesion locationBrain regionsPoststroke epilepsyControl patientsSeizure controlBrain lesionsIndependent cohortBrain networksLesion typeBrain stimulation sitesLesion network mappingLesion-related epilepsyImproved seizure controlDrug-resistant epilepsyCase-control studyBrain stimulation therapyHuman brain networksSpecific brain regionsDifferent lesion typesSpecific brain networksBasal gangliaVascular territoriesStimulation therapyMAIN OUTCOME
2022
Human visual consciousness involves large scale cortical and subcortical networks independent of task report and eye movement activity
Kronemer S, Aksen M, Ding J, Ryu J, Xin Q, Ding Z, Prince J, Kwon H, Khalaf A, Forman S, Jin D, Wang K, Chen K, Hu C, Agarwal A, Saberski E, Wafa S, Morgan O, Wu J, Christison-Lagay K, Hasulak N, Morrell M, Urban A, Todd Constable R, Pitts M, Mark Richardson R, Crowley M, Blumenfeld H. Human visual consciousness involves large scale cortical and subcortical networks independent of task report and eye movement activity. Nature Communications 2022, 13: 7342. PMID: 36446792, PMCID: PMC9707162, DOI: 10.1038/s41467-022-35117-4.Peer-Reviewed Original ResearchConceptsSubcortical networksConscious visual perceptionVisual perception taskNeurophysiology of consciousnessExecutive control networkMajor brain networksDefault mode networkFrontal eye fieldOvert reportPerception taskVisual consciousnessConscious perceptionFusiform cortexVisual perceptionAnterior insulaConscious experienceSalience networkBrain networksMode networkAnterior cingulateEye fieldTask reportControl networkFMRI changesNeural circuitsDistinct signatures of loss of consciousness in focal impaired awareness versus tonic-clonic seizures
Juan E, Górska U, Kozma C, Papantonatos C, Bugnon T, Denis C, Kremen V, Worrell G, Struck A, Bateman L, Merricks E, Blumenfeld H, Tononi G, Schevon C, Boly M. Distinct signatures of loss of consciousness in focal impaired awareness versus tonic-clonic seizures. Brain 2022, 146: 109-123. PMID: 36383415, PMCID: PMC10582624, DOI: 10.1093/brain/awac291.Peer-Reviewed Original ResearchConceptsBilateral tonic-clonic seizuresFocal impaired awarenessTonic-clonic seizuresLoss of consciousnessSeizure onset zoneSlow wave activityIntracranial EEG activityImpaired awarenessIctal recruitmentCortical activationOnset zoneHigh-gamma activityCross-frequency couplingFocal impaired awareness seizuresNegative prognostic consequencesSleep-like activityEEG activityCortical firing ratesParieto-occipital cortexPosterior brain regionsMulti-unit activityAwareness seizuresClinical outcomesPrognostic consequencesClinical signsThalamic activations in rat brain by fMRI during tactile (forepaw, whisker) and non-tactile (visual, olfactory) sensory stimulations
Sanganahalli BG, Thompson GJ, Parent M, Verhagen JV, Blumenfeld H, Herman P, Hyder F. Thalamic activations in rat brain by fMRI during tactile (forepaw, whisker) and non-tactile (visual, olfactory) sensory stimulations. PLOS ONE 2022, 17: e0267916. PMID: 35522646, PMCID: PMC9075615, DOI: 10.1371/journal.pone.0267916.Peer-Reviewed Original ResearchConceptsDorsal lateral geniculate nucleusVentral posterior medialVentral posterior lateralThalamic activationFunctional MRIPosterior medial thalamic nucleusMedial thalamic nucleiSensory stimuliLateral geniculate nucleusPost-mortem humanOlfactory stimuliHigh-field functional MRIField functional MRIWhisker stimuliDeep brain regionsRat thalamusThalamic nucleiGeniculate nucleusMediodorsal nucleusRat brainInferior colliculusThalamusDifferent sensory stimuliCortical activationCortical activity
2011
Where fMRI and Electrophysiology Agree to Disagree: Corticothalamic and Striatal Activity Patterns in the WAG/Rij Rat
Mishra AM, Ellens DJ, Schridde U, Motelow JE, Purcaro MJ, DeSalvo MN, Enev M, Sanganahalli BG, Hyder F, Blumenfeld H. Where fMRI and Electrophysiology Agree to Disagree: Corticothalamic and Striatal Activity Patterns in the WAG/Rij Rat. Journal Of Neuroscience 2011, 31: 15053-15064. PMID: 22016539, PMCID: PMC3432284, DOI: 10.1523/jneurosci.0101-11.2011.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainBrain MappingBrain WavesCerebral CortexCerebrovascular CirculationCorpus StriatumDisease Models, AnimalElectroencephalographyElectrophysiologyEpilepsyImage Processing, Computer-AssistedLaser-Doppler FlowmetryMagnetic Resonance ImagingNicotinic AntagonistsOxygenRatsRats, WistarThalamusTubocurarineVibrissaeConceptsCerebral blood flowCerebral blood volumeLocal field potentialsNeuronal activityLaser Doppler cerebral blood flowSubcortical structuresWAG/Rij ratsNeuronal activity decreasesHuman absence epilepsySpike-wave dischargesWAG/RijMultiunit activity recordingsFMRI signalsFunctional magnetic resonance imaging (fMRI) signalsMagnetic resonance imaging signalsFMRI decreasesCBF decreaseHemodynamic changesCerebral cortexBasal gangliaSomatosensory cortexAbsence epilepsyWhisker stimulationBlood flowAnimal models
2010
Dynamic Time Course of Typical Childhood Absence Seizures: EEG, Behavior, and Functional Magnetic Resonance Imaging
Bai X, Vestal M, Berman R, Negishi M, Spann M, Vega C, Desalvo M, Novotny EJ, Constable RT, Blumenfeld H. Dynamic Time Course of Typical Childhood Absence Seizures: EEG, Behavior, and Functional Magnetic Resonance Imaging. Journal Of Neuroscience 2010, 30: 5884-5893. PMID: 20427649, PMCID: PMC2946206, DOI: 10.1523/jneurosci.5101-09.2010.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBrainBrain MappingCerebrovascular CirculationChildElectroencephalographyEpilepsy, AbsenceFemaleHumansLinear ModelsMagnetic Resonance ImagingMaleModels, NeurologicalMotor ActivityNeuropsychological TestsPsychomotor PerformanceSeizuresSignal Processing, Computer-AssistedTime FactorsConceptsTypical childhood absence seizuresChildhood absence seizuresAbsence seizuresFMRI decreasesSeizure onsetHz spike-wave dischargesMagnetic resonance imaging changesFunctional magnetic resonance imaging (fMRI) changesTime courseHz generalized spikeSpike-wave dischargesFunctional magnetic resonance imagingMagnetic resonance imagingRepetitive tapping taskLateral parietal cortexLateral frontal cortexImpaired consciousnessPediatric patientsImaging changesEEG time-frequency analysisSeizure endMean durationSeizure initiationGeneralized spikeFMRI changes