2023
Decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures
McCafferty C, Gruenbaum B, Tung R, Li J, Zheng X, Salvino P, Vincent P, Kratochvil Z, Ryu J, Khalaf A, Swift K, Akbari R, Islam W, Antwi P, Johnson E, Vitkovskiy P, Sampognaro J, Freedman I, Kundishora A, Depaulis A, David F, Crunelli V, Sanganahalli B, Herman P, Hyder F, Blumenfeld H. Decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures. Nature Communications 2023, 14: 117. PMID: 36627270, PMCID: PMC9832004, DOI: 10.1038/s41467-022-35535-4.Peer-Reviewed Original ResearchConceptsThalamic neuronsAbsence seizuresSeizure onsetNeuronal firingConsciousness-impairing seizuresFemale rat modelLow-frequency electroencephalographic activityFunctional magnetic resonanceBehavioral arrestRat modelRhythmic firingTransient initial peakFiring increasesSeizuresNeuronal mechanismsElectroencephalographic activityNeuronsBrain state changesBrief episodesFiring decreasesInitial peakFiringMagnetic resonanceDistinct patternsOnset
2017
Functional MRI in Basic Epilepsy Research☆
Englot D, Blumenfeld H. Functional MRI in Basic Epilepsy Research☆. 2017 DOI: 10.1016/b978-0-12-809324-5.00092-4.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingInvasive electrophysiological techniquesPathophysiology of seizuresMagnetic resonance imagingWidespread brain networksUse of anestheticsBasic epilepsy researchConvulsive seizuresAnimal fMRI studiesSeizure onsetResonance imagingElectrophysiological techniquesFunctional MRIEpilepsy researchBrain functionSeizuresFMRI studyBrain networksEpilepsyFMRI investigationSignal changesPathophysiologyAnestheticsMRI
2010
Dynamic Time Course of Typical Childhood Absence Seizures: EEG, Behavior, and Functional Magnetic Resonance Imaging
Bai X, Vestal M, Berman R, Negishi M, Spann M, Vega C, Desalvo M, Novotny EJ, Constable RT, Blumenfeld H. Dynamic Time Course of Typical Childhood Absence Seizures: EEG, Behavior, and Functional Magnetic Resonance Imaging. Journal Of Neuroscience 2010, 30: 5884-5893. PMID: 20427649, PMCID: PMC2946206, DOI: 10.1523/jneurosci.5101-09.2010.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBrainBrain MappingCerebrovascular CirculationChildElectroencephalographyEpilepsy, AbsenceFemaleHumansLinear ModelsMagnetic Resonance ImagingMaleModels, NeurologicalMotor ActivityNeuropsychological TestsPsychomotor PerformanceSeizuresSignal Processing, Computer-AssistedTime FactorsConceptsTypical childhood absence seizuresChildhood absence seizuresAbsence seizuresFMRI decreasesSeizure onsetHz spike-wave dischargesMagnetic resonance imaging changesFunctional magnetic resonance imaging (fMRI) changesTime courseHz generalized spikeSpike-wave dischargesFunctional magnetic resonance imagingMagnetic resonance imagingRepetitive tapping taskLateral parietal cortexLateral frontal cortexImpaired consciousnessPediatric patientsImaging changesEEG time-frequency analysisSeizure endMean durationSeizure initiationGeneralized spikeFMRI changes
2009
IMAGING | Functional MRI in Basic Epilepsy Research
Englot D, Blumenfeld H. IMAGING | Functional MRI in Basic Epilepsy Research. 2009, 539-544. DOI: 10.1016/b978-012373961-2.00023-0.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingInvasive electrophysiological techniquesPathophysiology of seizuresMagnetic resonance imagingWidespread brain networksUse of anestheticsBasic epilepsy researchConvulsive seizuresAnimal fMRI studiesSeizure onsetResonance imagingElectrophysiological techniquesFunctional MRIEpilepsy researchBrain functionSeizuresFMRI studyBrain networksEpilepsyFMRI investigationSignal changesImagingPathophysiologyAnestheticsMRI