2024
Neuronal rhythmicity and cortical arousal in a mouse model of absence epilepsy
Khan W, Chopra S, Zheng X, Liu S, Paszkowski P, Valcarce-Aspegren M, Sieu L, Mcgill S, Mccafferty C, Blumenfeld H. Neuronal rhythmicity and cortical arousal in a mouse model of absence epilepsy. Experimental Neurology 2024, 381: 114925. PMID: 39151596, DOI: 10.1016/j.expneurol.2024.114925.Peer-Reviewed Original ResearchExtracellular single unit recordingsSingle unit recordingsMouse modelNeuronal firingAbsence epilepsyFiring patternsRat modelSeizure initiationMouse model of absence epilepsyIn vivo extracellular single unit recordingNeuronal activityUnit recordingsModel of absence epilepsySomatosensory barrel cortexC3H/HeJ mouse modelNeuronal firing rateHuman absence epilepsyDiverse firing patternsNeuronal rhythmicityArousal stateC3H/HeJ miceBarrel cortexStudy of neuronal activityCortical electroencephalographyFiring rate
2023
Decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures
McCafferty C, Gruenbaum B, Tung R, Li J, Zheng X, Salvino P, Vincent P, Kratochvil Z, Ryu J, Khalaf A, Swift K, Akbari R, Islam W, Antwi P, Johnson E, Vitkovskiy P, Sampognaro J, Freedman I, Kundishora A, Depaulis A, David F, Crunelli V, Sanganahalli B, Herman P, Hyder F, Blumenfeld H. Decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures. Nature Communications 2023, 14: 117. PMID: 36627270, PMCID: PMC9832004, DOI: 10.1038/s41467-022-35535-4.Peer-Reviewed Original ResearchConceptsThalamic neuronsAbsence seizuresSeizure onsetNeuronal firingConsciousness-impairing seizuresFemale rat modelLow-frequency electroencephalographic activityFunctional magnetic resonanceBehavioral arrestRat modelRhythmic firingTransient initial peakFiring increasesSeizuresNeuronal mechanismsElectroencephalographic activityNeuronsBrain state changesBrief episodesFiring decreasesInitial peakFiringMagnetic resonanceDistinct patternsOnset
2020
Thalamic Stimulation Improves Postictal Cortical Arousal and Behavior
Xu J, Galardi MM, Pok B, Patel KK, Zhao CW, Andrews JP, Singla S, McCafferty CP, Feng L, Musonza ET, Kundishora AJ, Gummadavelli A, Gerrard JL, Laubach M, Schiff ND, Blumenfeld H. Thalamic Stimulation Improves Postictal Cortical Arousal and Behavior. Journal Of Neuroscience 2020, 40: 7343-7354. PMID: 32826310, PMCID: PMC7534908, DOI: 10.1523/jneurosci.1370-20.2020.Peer-Reviewed Original ResearchConceptsDeep brain stimulationCentral lateral nucleusBilateral deep brain stimulationCortical slow-wave activityPostictal stateSlow wave activityPostictal periodImpaired consciousnessRefractory epilepsyLateral nucleusBrain stimulationNatural slow-wave sleepModest behavioral improvementCortical slow wavesNovel therapeutic strategiesSlow-wave sleepDisorders of consciousnessBehavioral tasksDepressed consciousnessDBS treatmentThalamic stimulationElectrical hippocampal stimulationFemale ratsHigh success rateRat model
2019
Up and Down States of Cortical Neurons in Focal Limbic Seizures
Yue Z, Freedman IG, Vincent P, Andrews JP, Micek C, Aksen M, Martin R, Zuckerman D, Perrenoud Q, Neske GT, Sieu LA, Bo X, Cardin JA, Blumenfeld H. Up and Down States of Cortical Neurons in Focal Limbic Seizures. Cerebral Cortex 2019, 30: 3074-3086. PMID: 31800015, PMCID: PMC7197089, DOI: 10.1093/cercor/bhz295.Peer-Reviewed Original ResearchConceptsFocal limbic seizuresDeep anesthesiaLimbic seizuresCortical neuronsVivo whole-cell recordingsDepressed cortical functionInput resistanceNeocortical slow wavesSubcortical arousal systemsLoss of consciousnessWhole-cell recordingsCortical-subcortical networksSeizure propagationMembrane potentialRat modelCortical functionTemporal lobeSeizuresCortical arousalExtracellular recordingsElectrophysiological propertiesCortical electrophysiologyFiring rateAnesthesiaArousal system
2016
Restoring Conscious Arousal During Focal Limbic Seizures with Deep Brain Stimulation
Kundishora AJ, Gummadavelli A, Ma C, Liu M, McCafferty C, Schiff ND, Willie JT, Gross RE, Gerrard J, Blumenfeld H. Restoring Conscious Arousal During Focal Limbic Seizures with Deep Brain Stimulation. Cerebral Cortex 2016, 27: 1964-1975. PMID: 26941379, PMCID: PMC5964488, DOI: 10.1093/cercor/bhw035.Peer-Reviewed Original ResearchConceptsFocal limbic seizuresDeep brain stimulationLimbic seizuresBrain stimulationImpaired consciousnessNetwork inhibition hypothesisRisk of mortalityNovel therapeutic approachesDual-site stimulationCentral lateral nucleusDisorders of consciousnessQuality of lifeFocal limbicSurgical therapyRefractory epilepsyFocal seizuresNucleus oralisBilateral stimulationIntralaminar thalamusRat modelTherapeutic approachesLateral nucleusBehavioral arousalConscious arousalResponsive neurostimulation