2019
Up and Down States of Cortical Neurons in Focal Limbic Seizures
Yue Z, Freedman IG, Vincent P, Andrews JP, Micek C, Aksen M, Martin R, Zuckerman D, Perrenoud Q, Neske GT, Sieu LA, Bo X, Cardin JA, Blumenfeld H. Up and Down States of Cortical Neurons in Focal Limbic Seizures. Cerebral Cortex 2019, 30: 3074-3086. PMID: 31800015, PMCID: PMC7197089, DOI: 10.1093/cercor/bhz295.Peer-Reviewed Original ResearchConceptsFocal limbic seizuresDeep anesthesiaLimbic seizuresCortical neuronsVivo whole-cell recordingsDepressed cortical functionInput resistanceNeocortical slow wavesSubcortical arousal systemsLoss of consciousnessWhole-cell recordingsCortical-subcortical networksSeizure propagationMembrane potentialRat modelCortical functionTemporal lobeSeizuresCortical arousalExtracellular recordingsElectrophysiological propertiesCortical electrophysiologyFiring rateAnesthesiaArousal system
2016
Restoring Conscious Arousal During Focal Limbic Seizures with Deep Brain Stimulation
Kundishora AJ, Gummadavelli A, Ma C, Liu M, McCafferty C, Schiff ND, Willie JT, Gross RE, Gerrard J, Blumenfeld H. Restoring Conscious Arousal During Focal Limbic Seizures with Deep Brain Stimulation. Cerebral Cortex 2016, 27: 1964-1975. PMID: 26941379, PMCID: PMC5964488, DOI: 10.1093/cercor/bhw035.Peer-Reviewed Original ResearchConceptsFocal limbic seizuresDeep brain stimulationLimbic seizuresBrain stimulationImpaired consciousnessNetwork inhibition hypothesisRisk of mortalityNovel therapeutic approachesDual-site stimulationCentral lateral nucleusDisorders of consciousnessQuality of lifeFocal limbicSurgical therapyRefractory epilepsyFocal seizuresNucleus oralisBilateral stimulationIntralaminar thalamusRat modelTherapeutic approachesLateral nucleusBehavioral arousalConscious arousalResponsive neurostimulation