2022
Human visual consciousness involves large scale cortical and subcortical networks independent of task report and eye movement activity
Kronemer S, Aksen M, Ding J, Ryu J, Xin Q, Ding Z, Prince J, Kwon H, Khalaf A, Forman S, Jin D, Wang K, Chen K, Hu C, Agarwal A, Saberski E, Wafa S, Morgan O, Wu J, Christison-Lagay K, Hasulak N, Morrell M, Urban A, Todd Constable R, Pitts M, Mark Richardson R, Crowley M, Blumenfeld H. Human visual consciousness involves large scale cortical and subcortical networks independent of task report and eye movement activity. Nature Communications 2022, 13: 7342. PMID: 36446792, PMCID: PMC9707162, DOI: 10.1038/s41467-022-35117-4.Peer-Reviewed Original ResearchConceptsSubcortical networksConscious visual perceptionVisual perception taskNeurophysiology of consciousnessExecutive control networkMajor brain networksDefault mode networkFrontal eye fieldOvert reportPerception taskVisual consciousnessConscious perceptionFusiform cortexVisual perceptionAnterior insulaConscious experienceSalience networkBrain networksMode networkAnterior cingulateEye fieldTask reportControl networkFMRI changesNeural circuits
2017
A Switch and Wave of Neuronal Activity in the Cerebral Cortex During the First Second of Conscious Perception
Herman WX, Smith RE, Kronemer SI, Watsky RE, Chen WC, Gober LM, Touloumes GJ, Khosla M, Raja A, Horien CL, Morse EC, Botta KL, Hirsch LJ, Alkawadri R, Gerrard JL, Spencer DD, Blumenfeld H. A Switch and Wave of Neuronal Activity in the Cerebral Cortex During the First Second of Conscious Perception. Cerebral Cortex 2017, 29: 461-474. PMID: 29194517, PMCID: PMC6319177, DOI: 10.1093/cercor/bhx327.Peer-Reviewed Original ResearchConceptsCerebral cortexVisual cortexHuman cerebral cortexDirect electrical recordingHz gamma powerDefault mode networkConscious perceptionNeuronal activityAssociation cortexBrain disordersIntracranial electrodesCortexMonophasic wavesMode networkCortex networkGamma powerGamma activationVisual thresholdFirst secondElectrical recordingsStimulus processingInitial activationStimuliActivationFindings
2016
Impaired consciousness in patients with absence seizures investigated by functional MRI, EEG, and behavioural measures: a cross-sectional study
Guo JN, Kim R, Chen Y, Negishi M, Jhun S, Weiss S, Ryu JH, Bai X, Xiao W, Feeney E, Rodriguez-Fernandez J, Mistry H, Crunelli V, Crowley MJ, Mayes LC, Constable RT, Blumenfeld H. Impaired consciousness in patients with absence seizures investigated by functional MRI, EEG, and behavioural measures: a cross-sectional study. The Lancet Neurology 2016, 15: 1336-1345. PMID: 27839650, PMCID: PMC5504428, DOI: 10.1016/s1474-4422(16)30295-2.Peer-Reviewed Original ResearchConceptsAbsence seizuresCross-sectional studyFMRI amplitudeFunctional MRIBehavioral impairmentsJuvenile absence epilepsyBilateral spike-wave dischargesOnset of seizuresPediatric neurology practiceNational InstituteSpike-wave dischargesPhysiological changesBehavioral responsesDefault mode networkImpaired task performanceSeizure durationImpaired consciousnessElectroencephalography changesNeurology practiceAbsence epilepsyFMRI changesBehavioral deficitsMAIN OUTCOMEBehavioral testingEEG changes
2011
The Default Mode Network and Altered Consciousness in Epilepsy
Danielson N, Guo J, Blumenfeld H. The Default Mode Network and Altered Consciousness in Epilepsy. Behavioural Neurology 2011, 24: 55-65. DOI: 10.1155/2011/912720.Peer-Reviewed Original ResearchLoss of consciousnessDefault mode networkDefault mode network activitySeizure typesMode networkArousal systemNetwork inhibition hypothesisTypes of seizuresSubcortical arousal systemsCertain cortical regionsPrecuneus/posterior cingulateLateral parietal cortexNetwork activityActive inhibitionAltered consciousnessAbsence seizuresCortical deactivationCortical areasEpileptic seizuresAwake statePosterior cingulateParietal cortexSeizuresCortical regionsElectrophysiological modalities