2016
Chapter 1 Neuroanatomical Basis of Consciousness
Blumenfeld H. Chapter 1 Neuroanatomical Basis of Consciousness. 2016, 3-29. DOI: 10.1016/b978-0-12-800948-2.00001-7.Peer-Reviewed Original ResearchSubcortical componentsAssociation cortexArousal systemGamma-amino butyric acidSubcortical arousal systemsHeteromodal association cortexFrontoparietal association cortexLevel of consciousnessAmino butyric acidUpper brainstemBasal forebrainWidespread projectionsLevel of alertnessCortical componentsSpecialized brain networksClinical disordersNeuroanatomical basisFunctional neuroanatomyCortical anatomyBrain networksCortexHemispheric specializationConsciousness systemMemory encodingVisual processing
2015
Decreased Subcortical Cholinergic Arousal in Focal Seizures
Motelow JE, Li W, Zhan Q, Mishra AM, Sachdev RN, Liu G, Gummadavelli A, Zayyad Z, Lee HS, Chu V, Andrews JP, Englot DJ, Herman P, Sanganahalli BG, Hyder F, Blumenfeld H. Decreased Subcortical Cholinergic Arousal in Focal Seizures. Neuron 2015, 85: 561-572. PMID: 25654258, PMCID: PMC4319118, DOI: 10.1016/j.neuron.2014.12.058.Peer-Reviewed Original ResearchConceptsTemporal lobe seizuresFocal temporal lobe seizuresReduced cholinergic neurotransmissionBilateral temporal lobesLoss of consciousnessPedunculopontine tegmental nucleusQuality of lifeBrainstem arousal systemsFunctional magnetic resonanceSeizure spreadCholinergic neuronsImpaired consciousnessFocal seizuresBasal forebrainAnterior hypothalamusCholinergic neurotransmissionTegmental nucleusLateral septumCortical functionRodent modelsTemporal lobeSubcortical regionsSeizuresImpair consciousnessSubcortical arousal