2019
Short AIP1 (ASK1-Interacting Protein-1) Isoform Localizes to the Mitochondria and Promotes Vascular Dysfunction
Li Z, Li L, Zhang H, Zhou HJ, Ji W, Min W. Short AIP1 (ASK1-Interacting Protein-1) Isoform Localizes to the Mitochondria and Promotes Vascular Dysfunction. Arteriosclerosis Thrombosis And Vascular Biology 2019, 40: 112-127. PMID: 31619063, PMCID: PMC7204498, DOI: 10.1161/atvbaha.119.312976.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAorta, ThoracicApoptosisArteriosclerosisBlotting, WesternCells, CulturedDisease Models, AnimalDNAEndothelium, VascularGene Expression RegulationGenome-Wide Association StudyHumansMiceMice, Inbred C57BLMice, TransgenicMicroscopy, FluorescenceMitochondriaRas GTPase-Activating ProteinsSignal TransductionConceptsN-terminal pleckstrin homology domainHuman genome-wide association studiesGenome-wide association studiesPleckstrin homology domainMitochondrial reactive oxygen species generationEndothelial cellsH3K9 trimethylationHomology domainReactive oxygen species productionOxygen species productionReactive oxygen speciesReactive oxygen species generationAssociation studiesRegulatory factorsEpigenetic inhibitionEC activationOxygen species generationDependent pathwayVascular endothelial cellsProteolytic degradationSpecies productionOxygen speciesVascular homeostasisMitochondriaSpecies generation
2013
SOCS1 Prevents Graft Arteriosclerosis by Preserving Endothelial Cell Function
Qin L, Huang Q, Zhang H, Liu R, Tellides G, Min W, Yu L. SOCS1 Prevents Graft Arteriosclerosis by Preserving Endothelial Cell Function. Journal Of The American College Of Cardiology 2013, 63: 21-29. PMID: 23994402, PMCID: PMC3932325, DOI: 10.1016/j.jacc.2013.08.694.Peer-Reviewed Original ResearchConceptsAdhesion molecule-1Cell adhesion molecule-1Graft arteriosclerosisMolecule-1Aortic endothelial cellsEndothelial cellsEndothelial functionGA progressionNeointima formationLate cardiac allograft failureVascular cell adhesion molecule-1Intercellular adhesion molecule-1Cytokine-induced adhesion molecule expressionCardiac allograft failureNormal endothelial functionEndothelial inflammatory responseInflammatory cell infiltrationMouse aortic endothelial cellsAdhesion molecule expressionPlatelet/endothelial cell adhesion molecule-1Better vascular functionEndothelial cell adhesion molecule-1Cytokine-induced expressionEndothelial adhesion moleculesCultured aortic endothelial cells
2010
Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis
Xie D, Gore C, Liu J, Pong RC, Mason R, Hao G, Long M, Kabbani W, Yu L, Zhang H, Chen H, Sun X, Boothman DA, Min W, Hsieh JT. Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 2485-2490. PMID: 20080667, PMCID: PMC2823864, DOI: 10.1073/pnas.0908133107.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBeta CateninBlotting, WesternCadherinsCell LineCell Line, TumorCell MovementEpithelial CellsGene ExpressionHumansImmunohistochemistryMaleMesodermMiceMice, NudeNeoplasm MetastasisNeoplasms, ExperimentalProstatic NeoplasmsRas GTPase-Activating ProteinsReverse Transcriptase Polymerase Chain ReactionRNA, Small InterferingTCF Transcription FactorsTransfectionTransplantation, HeterologousVimentinConceptsProstate cancerMesenchymal transitionDAB2IP expressionCarcinoma cellsMultiple lymph nodesMetastatic prostate cancerDistant organ metastasisAggressive prostate cancerMetastatic PCa cellsProstate cancer metastasisClinical prostate cancer specimensHuman normal prostatePotential therapeutic targetXenograft mouse modelProstate cancer specimensProstate carcinoma cellsLymph nodesOrgan metastasisPCa cellsRole of DAB2IPPrognostic biomarkerPCa metastasisKnockout miceTherapeutic targetHuman carcinoma cells