PIWI proteins are essential for early Drosophila embryogenesis
Mani SR, Megosh H, Lin H. PIWI proteins are essential for early Drosophila embryogenesis. Developmental Biology 2013, 385: 340-349. PMID: 24184635, PMCID: PMC3915879, DOI: 10.1016/j.ydbio.2013.10.017.Peer-Reviewed Original ResearchConceptsPIWI proteinsMitotic defectsEarly embryogenesisArgonaute/PIWI protein familySmall non-coding RNAsEarly Drosophila embryogenesisAsynchronous nuclear divisionPosttranscriptional gene regulationSevere mitotic defectsPIWI protein familyNon-coding RNAsCell cycle progressionCell cycle arrestGermline developmentDrosophila embryogenesisChromatin structureGene regulationSyncytial embryosMitotic machinerySomatic nucleiProtein familyPiwiNuclear divisionNuclear migrationEssential functionsRepressing the Repressor: A lincRNA as a MicroRNA Sponge in Embryonic Stem Cell Self-Renewal
Cheng EC, Lin H. Repressing the Repressor: A lincRNA as a MicroRNA Sponge in Embryonic Stem Cell Self-Renewal. Developmental Cell 2013, 25: 1-2. PMID: 23597480, PMCID: PMC3906851, DOI: 10.1016/j.devcel.2013.03.020.Peer-Reviewed Original ResearchCore pluripotency factors Oct4Embryonic Stem Cell Self-RenewalLarge intergenic noncoding RNAsStem Cell Self-RenewalPosttranscriptional gene regulationPluripotency factor OCT4Human embryonic stem cellsIntergenic noncoding RNAsCell Self-RenewalEmbryonic stem cellsGene regulationMicroRNA (miRNA) spongesDevelopmental cellsFactors OCT4Noncoding RNAsSelf-RenewalLinc-RORStem cellsMiR-145SpongesRepressorCellsNanogSOX2RNA