2020
Endoscopic Ultrasound-Guided Fine Needle Aspiration Cytologic Evaluation of Intraductal Papillary Mucinous Neoplasm and Mucinous Cystic Neoplasms of Pancreas
Gilani SM, Adeniran AJ, Cai G. Endoscopic Ultrasound-Guided Fine Needle Aspiration Cytologic Evaluation of Intraductal Papillary Mucinous Neoplasm and Mucinous Cystic Neoplasms of Pancreas. American Journal Of Clinical Pathology 2020, 154: 559-570. PMID: 32589187, DOI: 10.1093/ajcp/aqaa079.Peer-Reviewed Original ResearchConceptsIntraductal papillary mucinous neoplasmMucinous cystic neoplasmMucinous cystic lesionsHigh-grade dysplasiaPapillary mucinous neoplasmCystic neoplasmsMucinous neoplasmsAncillary testingFine-needle aspiration cytologic evaluationUltrasound-guided fine-needle aspiration cytologyEndoscopic ultrasound-guided fine-needle aspiration cytologyFine needle aspiration cytologyRisk of malignancyNeedle aspiration cytologyUse of cytologyPositive cytologic diagnosisCytologic categoriesModerate dysplasiaCystic lesionsCytopathology guidelinesInvasive malignancyMalignancy rateHistologic diagnosisCytologic evaluationEndoscopic ultrasound
2019
A Semiquantitative Scoring System May Allow Biopsy Diagnosis of Pulmonary Large Cell Neuroendocrine Carcinoma
Baine MK, Sinard JH, Cai G, Homer RJ. A Semiquantitative Scoring System May Allow Biopsy Diagnosis of Pulmonary Large Cell Neuroendocrine Carcinoma. American Journal Of Clinical Pathology 2019, 153: 165-174. PMID: 31593583, PMCID: PMC7571487, DOI: 10.1093/ajcp/aqz149.Peer-Reviewed Original ResearchLoss of thymidine kinase 1 inhibits lung cancer growth and metastatic attributes by reducing GDF15 expression
Malvi P, Janostiak R, Nagarajan A, Cai G, Wajapeyee N. Loss of thymidine kinase 1 inhibits lung cancer growth and metastatic attributes by reducing GDF15 expression. PLOS Genetics 2019, 15: e1008439. PMID: 31589613, PMCID: PMC6797230, DOI: 10.1371/journal.pgen.1008439.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinoma of LungAdultAgedAnimalsBiomarkers, TumorCell Line, TumorCell MovementCell ProliferationDatasets as TopicDNA-Binding ProteinsFemaleGene Expression Regulation, NeoplasticGene Knockdown TechniquesGrowth Differentiation Factor 15HumansLungLung NeoplasmsMaleMiceMiddle AgedNeoplasm Recurrence, LocalPrognosisSurvival AnalysisThymidine KinaseTranscription FactorsXenograft Model Antitumor AssaysConceptsShort hairpin RNALUAD cellsMetastatic attributesRho GTPase activityMAP kinase pathwayEctopic expressionGTPase activityTranscriptional overexpressionKinase pathwayKinase 1Cancer cell growthGenetic knockdownProfiling-based approachDifferentiation factor 15Hairpin RNALung adenocarcinoma patientsLung cancer growthCell growthLUAD therapyDownstream mediatorLUAD tumorsLUAD growthKey hallmarksReduced expressionDependent mannerImproved Diagnostic Yield and Specimen Quality With Endobronchial Ultrasound-Guided Forceps Biopsies: A Retrospective Analysis
Ray AS, Li C, Murphy TE, Cai G, Araujo KLB, Bramley K, DeBiasi EM, Pisani MA, Cortopassi IO, Puchalski JT. Improved Diagnostic Yield and Specimen Quality With Endobronchial Ultrasound-Guided Forceps Biopsies: A Retrospective Analysis. The Annals Of Thoracic Surgery 2019, 109: 894-901. PMID: 31593653, PMCID: PMC9376016, DOI: 10.1016/j.athoracsur.2019.08.106.Peer-Reviewed Original ResearchConceptsStandard of careTransbronchial needle aspirationDiagnostic yieldHilar lymphadenopathyEndobronchial ultrasound transbronchial needle aspirationMediastinal/hilar lymphadenopathySolid organ malignanciesHigh diagnostic yieldGood tissue qualitySpecimen qualityForceps biopsyEBUS-TBNAParenchymal findingsPreprocedural imagingEndobronchial ultrasoundNeedle aspirationRetrospective analysisLymphadenopathyDiagnostic criteriaPatient basisDisease processTissue acquisitionPatientsClinical scenariosSarcoidosisEGFR mutation subtypes and response to immune checkpoint blockade treatment in non-small-cell lung cancer
Hastings K, Yu HA, Wei W, Sanchez-Vega F, DeVeaux M, Choi J, Rizvi H, Lisberg A, Truini A, Lydon CA, Liu Z, Henick BS, Wurtz A, Cai G, Plodkowski AJ, Long NM, Halpenny DF, Killam J, Oliva I, Schultz N, Riely GJ, Arcila ME, Ladanyi M, Zelterman D, Herbst RS, Goldberg SB, Awad MM, Garon EB, Gettinger S, Hellmann MD, Politi K. EGFR mutation subtypes and response to immune checkpoint blockade treatment in non-small-cell lung cancer. Annals Of Oncology 2019, 30: 1311-1320. PMID: 31086949, PMCID: PMC6683857, DOI: 10.1093/annonc/mdz141.Peer-Reviewed Original ResearchMeSH KeywordsAgedAllelesAntineoplastic Agents, ImmunologicalB7-H1 AntigenBiomarkers, TumorCarcinoma, Non-Small-Cell LungDrug Resistance, NeoplasmErbB ReceptorsFemaleGenetic HeterogeneityHumansLungLung NeoplasmsMaleMiddle AgedMutationProgrammed Cell Death 1 ReceptorProgression-Free SurvivalRetrospective StudiesTobacco SmokingConceptsEGFR-mutant tumorsMemorial Sloan-Kettering Cancer CenterYale Cancer CenterImmune checkpoint inhibitorsPD-L1 expressionImmune checkpoint blockadeTumor mutation burdenCancer CenterLung tumorsCheckpoint blockadeEGFR mutant lung tumorsMutant tumorsCheckpoint inhibitorsLung cancerMutation burdenImmune checkpoint blockade treatmentLow tumor mutation burdenDana-Farber Cancer InstituteEGFR wild-type lung cancersCheckpoint blockade treatmentCell lung cancerEGFR mutation subtypesSimilar smoking historyCell death 1Lung cancer cases
2013
Evaluation of endobronchial ultrasound‐guided fine‐needle aspirations (EBUS‐FNA): Correlation with adequacy and histologic follow‐up
Karunamurthy A, Cai G, Dacic S, Khalbuss WE, Pantanowitz L, Monaco SE. Evaluation of endobronchial ultrasound‐guided fine‐needle aspirations (EBUS‐FNA): Correlation with adequacy and histologic follow‐up. Cancer Cytopathology 2013, 122: 23-32. PMID: 24127207, DOI: 10.1002/cncy.21350.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiopsy, NeedleCohort StudiesDatabases, FactualEndoscopic Ultrasound-Guided Fine Needle AspirationFalse Negative ReactionsFemaleHumansImmunohistochemistryLung NeoplasmsLymph NodesMaleMediastinal NeoplasmsMiddle AgedRetrospective StudiesSensitivity and SpecificityConceptsEndobronchial ultrasound-guided fine-needle aspirationUltrasound-guided fine-needle aspirationLymph nodesFine-needle aspirationDiagnostic yieldN1 lymph nodesN2 lymph nodesNegative cytologic diagnosisHilar lymph nodesMediastinal lymph nodesOverall diagnostic yieldChance of malignancyHigh diagnostic yieldNegative predictive valueFalse-negative diagnosesClinicopathologic findingsMediastinal lesionsLymphoid tissueInvasive modalitiesCytologic diagnosisPredictive valueUnsatisfactory casesGreater riskHistologicDiagnostic materialIdentification of EGFR mutation, KRAS mutation, and ALK gene rearrangement in cytological specimens of primary and metastatic lung adenocarcinoma
Cai G, Wong R, Chhieng D, Levy GH, Gettinger SN, Herbst RS, Puchalski JT, Homer RJ, Hui P. Identification of EGFR mutation, KRAS mutation, and ALK gene rearrangement in cytological specimens of primary and metastatic lung adenocarcinoma. Cancer Cytopathology 2013, 121: 500-507. PMID: 23495083, DOI: 10.1002/cncy.21288.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAged, 80 and overAnaplastic Lymphoma KinaseBiomarkers, TumorBone NeoplasmsCytodiagnosisDNA, NeoplasmErbB ReceptorsFeasibility StudiesFemaleGene RearrangementHumansIn Situ Hybridization, FluorescenceLiver NeoplasmsLung NeoplasmsMaleMiddle AgedMutationNeoplasm Recurrence, LocalPrognosisProto-Oncogene ProteinsProto-Oncogene Proteins p21(ras)Ras ProteinsReal-Time Polymerase Chain ReactionReceptor Protein-Tyrosine KinasesSoft Tissue NeoplasmsYoung AdultConceptsALK gene rearrangementMetastatic lung adenocarcinomaEGFR mutationsKRAS mutationsMetastatic tumorsEpidermal growth factor receptorLung adenocarcinomaCytological specimensGene rearrangementsMolecular testsMolecular alterationsKirsten rat sarcoma viral oncogene homolog (KRAS) mutationsALK gene rearrangement analysisAnaplastic lymphoma kinase (ALK) gene rearrangementEGFR T790M mutationRat sarcoma viral oncogene homolog mutationsCases of lungT790M mutationImportant therapeutic implicationsFine needle aspiratesGene rearrangement analysisCell block materialGrowth factor receptorRecurrent lungRecurrent adenocarcinoma
2012
Diagnostic value of K‐ras mutation analysis for pancreaticobiliary cytology specimens with indeterminate diagnosis
Cai G, Mahooti S, Lipata FM, Chhieng D, Hui P. Diagnostic value of K‐ras mutation analysis for pancreaticobiliary cytology specimens with indeterminate diagnosis. Cancer Cytopathology 2012, 120: 313-318. PMID: 22367918, DOI: 10.1002/cncy.21188.Peer-Reviewed Original Research
2011
The cytomorphologic spectrum of salivary gland type tumors in the lung and mediastinum: A report of 16 patients
Monaco SE, Khalbuss WE, Ustinova E, Liang A, Cai G. The cytomorphologic spectrum of salivary gland type tumors in the lung and mediastinum: A report of 16 patients. Diagnostic Cytopathology 2011, 40: 1062-1070. PMID: 21591276, DOI: 10.1002/dc.21733.Peer-Reviewed Original ResearchConceptsSalivary gland-type tumorsMucoepidermoid carcinomaPrimary tumorType tumorsPolymorphous low-grade adenocarcinomaCommon histological subtypeAspiration cytology specimensDiagnosis of ACCSalivary duct carcinomaLow-grade adenocarcinomaMinor salivary glandsCytomorphologic spectrumDuct carcinomaHistological subtypesBasaloid tumorsCystic carcinomaCytomorphologic featuresSoft palateGrade adenocarcinomaDiagnostic pitfallsNasal cavityCytology casesCytology specimensMediastinumTumors