2024
Endovascular Treatment of Acute Ischemic Stroke After Cardiac Interventions in the United States
de Havenon A, Zhou L, Koo A, Matouk C, Falcone G, Sharma R, Ney J, Shu L, Yaghi S, Kamel H, Sheth K. Endovascular Treatment of Acute Ischemic Stroke After Cardiac Interventions in the United States. JAMA Neurology 2024, 81: 264-272. PMID: 38285452, PMCID: PMC10825786, DOI: 10.1001/jamaneurol.2023.5416.Peer-Reviewed Original ResearchNational Institutes of Health Stroke ScaleNational Institutes of Health Stroke Scale scoreOdds of discharge homeDischarged homeIschemic strokeRate of endovascular thrombectomyMultivariate logistic regressionNational Inpatient Sample databaseHealth Stroke ScaleIntervention patientsInpatient Sample databaseMain OutcomesIntervention statusHospitalization of patientsPotential confoundersUS hospitalsEndovascular thrombectomyStroke patientsCohort studySecondary outcomesLogistic regressionCardiac interventionsStroke severityStroke ScaleGroup of hospitalized patients
2023
Emergent external ventricular drain placement in patients with factor Xa inhibitor-associated intracerebral hemorrhage after reversal with andexanet alfa
Ammar A, Elsamadicy A, Ammar M, Reeves B, Koo A, Falcone G, Hwang D, Petersen N, Kim J, Beekman R, Prust M, Magid-Bernstein J, Acosta J, Herbert R, Sheth K, Matouk C, Gilmore E. Emergent external ventricular drain placement in patients with factor Xa inhibitor-associated intracerebral hemorrhage after reversal with andexanet alfa. Clinical Neurology And Neurosurgery 2023, 226: 107621. PMID: 36791588, DOI: 10.1016/j.clineuro.2023.107621.Peer-Reviewed Original ResearchConceptsAndexanet alfaExtra-axial hemorrhageEVD placementThrombotic eventsNew hemorrhagePrimary safety outcomeExternal ventricular drain placementLarge prospective studiesIntensive care unitIntracerebral hemorrhage patientsVentricular drain placementBolus patientsHospital lengthHospital LOSICU LOSTract hemorrhageRankin scoreSecondary outcomesAdult patientsBolus groupPrimary outcomeCare unitIntracerebral hemorrhageLong administration timeHemorrhage patients
2022
Association of Intraventricular Fibrinolysis With Clinical Outcomes in Intracerebral Hemorrhage: An Individual Participant Data Meta-Analysis
Kuramatsu JB, Gerner ST, Ziai W, Bardutzky J, Sembill JA, Sprügel MI, Mrochen A, Kölbl K, Ram M, Avadhani R, Falcone GJ, Selim MH, Lioutas VA, Endres M, Zweynert S, Vajkoczy P, Ringleb PA, Purrucker JC, Volkmann J, Neugebauer H, Erbguth F, Schellinger PD, Knappe UJ, Fink GR, Dohmen C, Minnerup J, Reichmann H, Schneider H, Röther J, Reimann G, Schwarz M, Bäzner H, Claßen J, Michalski D, Witte OW, Günther A, Hamann GF, Lücking H, Dörfler A, Ishfaq MF, Chang JJ, Testai FD, Woo D, Alexandrov AV, Staykov D, Goyal N, Tsivgoulis G, Sheth KN, Awad IA, Schwab S, Hanley DF, Huttner HB, Sansing L, Matouk C, Leasure A, Sobesky J, Bauer M, Schurig J, Rizos T, Haeusler K, Müllges W, Kraft P, Schubert A, Stösser S, Ludolph A, Nueckel M, Glahn J, Stetefeld H, Rahmig J, Fisse A, Michels P, Schwert H, Hagemann G, Rakers F, Wöhrle J, Alshammari F, Horn M, Bahner D, Urbanek C, Palm F, Grau A. Association of Intraventricular Fibrinolysis With Clinical Outcomes in Intracerebral Hemorrhage: An Individual Participant Data Meta-Analysis. Stroke 2022, 53: 2876-2886. PMID: 35521958, PMCID: PMC9398945, DOI: 10.1161/strokeaha.121.038455.Peer-Reviewed Original ResearchConceptsAbsolute treatment effectStandard of careIntraventricular fibrinolysisIntracerebral hemorrhageIntraventricular hemorrhagePrimary outcomeAcute hydrocephalusAdverse eventsFunctional disabilityIVF treatmentFunctional outcomeOdds ratioOrdinal shift analysisIndividual Participant Data Meta-AnalysisModified Rankin ScaleExternal ventricular drainageImproved functional outcomesData Meta-AnalysisPromising therapeutic targetTreatment effectsIndividual participant dataCause mortalityRankin ScaleSecondary outcomesSymptom onset
2021
Diffusion-Weighted Imaging Lesions After Intracerebral Hemorrhage and Risk of Stroke
Murthy SB, Zhang C, Gupta A, Cho SM, Rivera-Lara L, Avadhani R, Gruber J, Iadecola C, Falcone GJ, Sheth KN, Qureshi AI, Goldstein JN, Hanley DF, Kamel H, Ziai WC. Diffusion-Weighted Imaging Lesions After Intracerebral Hemorrhage and Risk of Stroke. Stroke 2021, 52: 595-602. PMID: 33467877, PMCID: PMC8340082, DOI: 10.1161/strokeaha.120.031628.Peer-Reviewed Original ResearchConceptsRecurrent intracerebral hemorrhageRisk of strokeIntracerebral hemorrhageDWI lesionsIschemic strokeDiffusion-weighted imagingDiffusion-weighted imaging lesionsMultivariate Cox regression analysisMISTIE III trialIncident ischemic strokeCox regression analysisPoor functional outcomeCox regression modelIndividual patient dataATACH-2 trialLong-term riskMagnetic resonance imagingICH survivorsIncident strokeIII trialsImaging lesionsSecondary outcomesIschemic lesionsPrimary outcomeFunctional outcome
2020
A Pooled Analysis of Diffusion-Weighted Imaging Lesions in Patients With Acute Intracerebral Hemorrhage
Murthy SB, Cho SM, Gupta A, Shoamanesh A, Navi BB, Avadhani R, Gruber J, Li Y, Greige T, Lioutas VA, Norton C, Zhang C, Mandava P, Iadecola C, Falcone GJ, Sheth KN, Biffi A, Rosand J, Qureshi AI, Goldstein JN, Kidwell C, Awad I, Selim M, Hanley DF, Woo D, Kamel H, Ziai WC. A Pooled Analysis of Diffusion-Weighted Imaging Lesions in Patients With Acute Intracerebral Hemorrhage. JAMA Neurology 2020, 77: 1390-1397. PMID: 32687564, PMCID: PMC7372494, DOI: 10.1001/jamaneurol.2020.2349.Peer-Reviewed Original ResearchConceptsDiffusion-weighted imaging lesionsModified Rankin scoreDWI lesionsImaging lesionsAcute intracerebral hemorrhageIntracerebral hemorrhageFunctional outcomeSubgroup analysisChronic cerebral small vessel diseaseAdmission systolic blood pressureCerebral small vessel diseaseMulticenter prospective studySystolic blood pressurePoor functional outcomeSmall vessel diseaseDeep intracerebral hemorrhageBaseline hematoma volumeIndividual patient dataMixed-effects logistic regressionMixed effects regression modelsAcute sequelaeHypertensive vasculopathyRankin scoreSecondary outcomesBlood pressurePrior antiplatelet therapy and haematoma expansion after primary intracerebral haemorrhage: an individual patient-level analysis of CLEAR III, MISTIE III and VISTA-ICH
Murthy S, Roh DJ, Chatterjee A, McBee N, Parikh NS, Merkler AE, Navi BB, Falcone GJ, Sheth KN, Awad I, Hanley D, Kamel H, Ziai WC. Prior antiplatelet therapy and haematoma expansion after primary intracerebral haemorrhage: an individual patient-level analysis of CLEAR III, MISTIE III and VISTA-ICH. Journal Of Neurology Neurosurgery & Psychiatry 2020, 92: 364-369. PMID: 33106367, PMCID: PMC8071838, DOI: 10.1136/jnnp-2020-323458.Peer-Reviewed Original ResearchPrior antiplatelet therapyAntiplatelet therapyLobar intracerebral hemorrhageIntracerebral hemorrhagePrimary intracerebral hemorrhageHaematoma expansionHaematoma volumeHaematoma locationCause mortalityIII trialsStudy cohortMajor disabilitySecondary analysisIndividual patient-level analysisPhase III trialsLarge heterogeneous cohortIndividual patient dataPatient-level analysisMISTIE IIISecondary outcomesDeep hemorrhagesPrimary outcomeICH locationMRS distributionFunctional outcomeNon-Traumatic Subdural Hemorrhage and Risk of Arterial Ischemic Events
Murthy SB, Wu X, Diaz I, Parasram M, Parikh NS, Iadecola C, Merkler AE, Falcone GJ, Brown S, Biffi A, Ch'ang J, Knopman J, Stieg PE, Navi BB, Sheth KN, Kamel H. Non-Traumatic Subdural Hemorrhage and Risk of Arterial Ischemic Events. Stroke 2020, 51: 1464-1469. PMID: 32178587, PMCID: PMC7188584, DOI: 10.1161/strokeaha.119.028510.Peer-Reviewed Original ResearchConceptsArterial ischemic eventsAcute ischemic strokeIschemic eventsIschemic strokeSubdural hemorrhageMyocardial infarctionAntithrombotic therapyMedicare beneficiariesSDH diagnosisPatient riskSecondary analysisRetrospective cohort studyAcute myocardial infarctionCohort studyHazard ratioSecondary outcomesVascular comorbiditiesPrimary outcomeCox regressionDiagnosis codesClaims dataInternational ClassificationPrimary analysisInfarctionStroke
2019
Deep Learning for Automated Measurement of Hemorrhage and Perihematomal Edema in Supratentorial Intracerebral Hemorrhage
Dhar R, Falcone GJ, Chen Y, Hamzehloo A, Kirsch EP, Noche RB, Roth K, Acosta J, Ruiz A, Phuah CL, Woo D, Gill TM, Sheth KN, Lee JM. Deep Learning for Automated Measurement of Hemorrhage and Perihematomal Edema in Supratentorial Intracerebral Hemorrhage. Stroke 2019, 51: 648-651. PMID: 31805845, PMCID: PMC6993878, DOI: 10.1161/strokeaha.119.027657.Peer-Reviewed Original ResearchConceptsSupratentorial intracerebral hemorrhagePerihematomal edemaIntracerebral hemorrhagePHE volumeResults Two hundred twentyIntracerebral Hemorrhage (ERICH) studyMechanism of injuryIntracerebral hemorrhage patientsSpontaneous intracerebral hemorrhageLarge cohort studyComputed tomography scanSecondary outcomesCohort studyPrimary outcomeHemorrhage patientsSecondary injuryTomography scanHundred twentyMedian volumeLarge cohortHemorrhagePatientsQuantification of hemorrhageFirst cohortDisease biologyAssociation of Surgical Hematoma Evacuation vs Conservative Treatment With Functional Outcome in Patients With Cerebellar Intracerebral Hemorrhage
Kuramatsu JB, Biffi A, Gerner ST, Sembill JA, Sprügel MI, Leasure A, Sansing L, Matouk C, Falcone GJ, Endres M, Haeusler KG, Sobesky J, Schurig J, Zweynert S, Bauer M, Vajkoczy P, Ringleb PA, Purrucker J, Rizos T, Volkmann J, Müllges W, Kraft P, Schubert AL, Erbguth F, Nueckel M, Schellinger PD, Glahn J, Knappe UJ, Fink GR, Dohmen C, Stetefeld H, Fisse AL, Minnerup J, Hagemann G, Rakers F, Reichmann H, Schneider H, Rahmig J, Ludolph AC, Stösser S, Neugebauer H, Röther J, Michels P, Schwarz M, Reimann G, Bäzner H, Schwert H, Claßen J, Michalski D, Grau A, Palm F, Urbanek C, Wöhrle JC, Alshammari F, Horn M, Bahner D, Witte OW, Günther A, Hamann GF, Hagen M, Roeder SS, Lücking H, Dörfler A, Testai FD, Woo D, Schwab S, Sheth KN, Huttner HB. Association of Surgical Hematoma Evacuation vs Conservative Treatment With Functional Outcome in Patients With Cerebellar Intracerebral Hemorrhage. JAMA 2019, 322: 1392-1403. PMID: 31593272, PMCID: PMC6784768, DOI: 10.1001/jama.2019.13014.Peer-Reviewed Original ResearchConceptsCerebellar intracerebral hemorrhageSurgical hematoma evacuationHematoma evacuationConservative treatmentIntracerebral hemorrhageIndividual participant dataFunctional outcomePrimary outcomeClinical outcomesFunctional disabilityPropensity score-matched groupsFavorable functional outcomeModified Rankin ScaleImproved functional outcomesSecondary outcomesRankin ScaleHematoma volumeICH studiesMAIN OUTCOMEPatientsCutoff valuePropensity scoreParticipant dataMonthsCovariate adjustment