2022
Racial/Ethnic Variation in White Matter Hyperintensity Progression in the ACCORDION MIND Study
Herman AL, de Havenon A, Falcone GJ, Prabhakaran S, Sheth KN. Racial/Ethnic Variation in White Matter Hyperintensity Progression in the ACCORDION MIND Study. The Neurologist 2022, 28: 157-159. PMID: 35834785, DOI: 10.1097/nrl.0000000000000454.Peer-Reviewed Original ResearchConceptsWMH progressionWhite matter hyperintensitiesLow-density lipoproteinCardiovascular riskWhite patientsBlack patientsWMH volumeSystolic blood pressure levelsWhite matter hyperintensity progressionBlack diabetic patientsBlood pressure levelsExclusion of patientsMagnetic resonance imagingDiabetes (ACCORD) trialDiabetic patientsMean SBPPrimary outcomePatient raceMultivariate regression modelMatter hyperintensitiesA1c measurementHigh riskPatientsNormal rangeCognitive decline
2014
Accuracy of imputation to infer unobserved APOE epsilon alleles in genome-wide genotyping data
Radmanesh F, Devan WJ, Anderson CD, Rosand J, Falcone GJ. Accuracy of imputation to infer unobserved APOE epsilon alleles in genome-wide genotyping data. European Journal Of Human Genetics 2014, 22: 1239-1242. PMID: 24448547, PMCID: PMC4169533, DOI: 10.1038/ejhg.2013.308.Peer-Reviewed Original ResearchMeSH KeywordsAllelesAlzheimer DiseaseApolipoproteins ECase-Control StudiesCerebral HemorrhageGene FrequencyGenome, HumanGenome-Wide Association StudyGenotypeGenotyping TechniquesHapMap ProjectHumansLogistic ModelsLongitudinal StudiesPolymorphism, Single NucleotidePrincipal Component AnalysisProspective StudiesQuality ControlWhite PeopleConceptsIntracerebral hemorrhageAlzheimer's diseaseSingle nucleotide polymorphismsEpsilon allelesAPOE epsilon allelesCerebral amyloid angiopathyLate-onset Alzheimer's diseaseCatabolism of chylomicronsLow-density lipoproteinGenetic risk factorsAmyloid angiopathyCommon single nucleotide polymorphismsRisk factorsApolipoprotein EDensity lipoproteinControl groupMain apoproteinApoEDiseaseGenome-wide genotyping dataEuropean ancestryImproved balanceHapMap reference panelsGenome-wide genotyping arraysAlleles