2024
Burden of Ischemic and Hemorrhagic Stroke Across the US From 1990 to 2019
Renedo D, Acosta J, Leasure A, Sharma R, Krumholz H, de Havenon A, Alahdab F, Aravkin A, Aryan Z, Bärnighausen T, Basu S, Burkart K, Coberly K, Criqui M, Dai X, Desai R, Dharmaratne S, Doshi R, Elgendy I, Feigin V, Filip I, Gad M, Ghozy S, Hafezi-Nejad N, Kalani R, Karaye I, Kisa A, Krishnamoorthy V, Lo W, Mestrovic T, Miller T, Misganaw A, Mokdad A, Murray C, Natto Z, Radfar A, Ram P, Roth G, Seylani A, Shah N, Sharma P, Sheikh A, Singh J, Song S, Sotoudeh H, Vervoort D, Wang C, Xiao H, Xu S, Zand R, Falcone G, Sheth K. Burden of Ischemic and Hemorrhagic Stroke Across the US From 1990 to 2019. JAMA Neurology 2024, 81: 394-404. PMID: 38436973, PMCID: PMC10913004, DOI: 10.1001/jamaneurol.2024.0190.Peer-Reviewed Original ResearchBurden of strokeHemorrhagic strokeBurden trendsGlobal burdenGlobal Burden of Disease StudyBurden of Disease StudyAge-standardized ratesAge-standardized estimatesPublic health policiesStroke-related outcomesIschemic strokeCross-sectional studyPublic health challengeCross-sectional analysisStroke mortalityStroke burdenHealth policyOlder adultsMain OutcomesStroke incidenceStroke casesIntracerebral hemorrhageEscalating burdenHealth challengesSignificant disparitiesCOVID‐19 Infection Is Associated With Poor Outcomes in Patients With Intracerebral Hemorrhage
Renedo D, Leasure A, Young R, Rivier C, Alhanti B, Mac Grory B, Messe S, Reeves M, Hassan A, Schwamm L, de Havenon A, Matouk C, Sheth K, Falcone G. COVID‐19 Infection Is Associated With Poor Outcomes in Patients With Intracerebral Hemorrhage. Journal Of The American Heart Association 2024, 13: e030999. PMID: 38293940, PMCID: PMC11056169, DOI: 10.1161/jaha.123.030999.Peer-Reviewed Original ResearchConceptsOdds of poor outcomeIntracerebral hemorrhageCOVID-19 infectionPoor outcomeHealth care deliverySkilled nursing facilityMultivariate analysisOdds of mortalityConcomitant COVID-19 infectionAssociated with poor outcomesCare deliveryNursing facilitiesPoor functional outcomeCOVID-19OddsICH outcomeImpact of COVID-19No significant differenceObservational studyHemorrhagic strokeWorsen outcomesPatient populationFunctional outcomesStroke dataPatients
2023
Higher Hospital Frailty Risk Score Is Associated With Increased Risk of Stroke: Observational and Genetic Analyses
Renedo D, Acosta J, Koo A, Rivier C, Sujijantarat N, de Havenon A, Sharma R, Gill T, Sheth K, Falcone G, Matouk C. Higher Hospital Frailty Risk Score Is Associated With Increased Risk of Stroke: Observational and Genetic Analyses. Stroke 2023, 54: 1538-1547. PMID: 37216451, PMCID: PMC10212531, DOI: 10.1161/strokeaha.122.041891.Peer-Reviewed Original ResearchConceptsHospital Frailty Risk ScoreRisk of strokeHighest Hospital Frailty Risk ScoresDate of consentFrailty Risk ScoreMendelian randomization analysisStroke riskRisk scoreRandomization analysisTime of enrollmentAvailable electronic health recordsMendelian randomizationElectronic health recordsLook-back periodIncident strokeDose-response wayFrailty statusHemorrhagic strokeMultivariable analysisStroke eventsObservational studyHigh riskFrailtySignificant associationSimilar associationPolygenic Susceptibility to Hypertension and Blood Pressure Control in Stroke Survivors
Acosta J, Both C, Demarais Z, Conlon C, Leasure A, Torres-Lopez V, de Havenon A, Petersen N, Gill T, Sansing L, Sheth K, Falcone G. Polygenic Susceptibility to Hypertension and Blood Pressure Control in Stroke Survivors. Neurology 2023, 100: e1587-e1597. PMID: 36690452, PMCID: PMC10103110, DOI: 10.1212/wnl.0000000000206763.Peer-Reviewed Original ResearchConceptsWorse BP controlUncontrolled blood pressureDiastolic blood pressureBlood pressureStroke survivorsPolygenic risk scoresBP controlPolygenic susceptibilityMean diastolic blood pressureMean systolic blood pressureStroke Prevention TrialBlood pressure controlSystolic blood pressureResistant hypertensionVascular eventsHemorrhagic strokePrevention trialsVitamin InterventionMultivariable modelRisk scoreGenetic predispositionPressure controlLogistic regressionSurvivorsHypertension
2021
Mendelian Randomization in Stroke: A Powerful Approach to Causal Inference and Drug Target Validation
Acosta JN, Szejko N, Falcone GJ. Mendelian Randomization in Stroke: A Powerful Approach to Causal Inference and Drug Target Validation. Frontiers In Genetics 2021, 12: 683082. PMID: 34456968, PMCID: PMC8387928, DOI: 10.3389/fgene.2021.683082.Peer-Reviewed Original ResearchMendelian randomizationCardiovascular risk factorsRisk of strokeAvailable treatment optionsInflammation-related mechanismsIschemic strokeHemorrhagic strokeTreatment optionsRisk factorsLeading causeCurrent evidenceTherapeutic targetStrokeMR studiesNovel biological pathwaysDrug repurposingDrug developmentDrug target validationRandomizationTarget validationExposureBiological pathwaysCausal relationshipDisease
2020
Statin treatment and cerebral microbleeds: A systematic review and meta-analysis
Katsanos AH, Lioutas VA, Charidimou A, Catanese L, Ng KKH, Perera K, Boasquevisque D, Falcone GJ, Sheth KN, Romero JR, Tsivgoulis G, Smith EE, Sharma M, Selim MH, Shoamanesh A, Initiative T. Statin treatment and cerebral microbleeds: A systematic review and meta-analysis. Journal Of The Neurological Sciences 2020, 420: 117224. PMID: 33183779, DOI: 10.1016/j.jns.2020.117224.Peer-Reviewed Original ResearchConceptsCMB presenceStatin useCurrent statin useStatin treatmentRandomized-controlled clinical trialSpontaneous intracerebral hemorrhageRandom-effects modelCMB prevalenceIschemic strokeHemorrhagic strokeAdjusted analysisCerebral microbleedsIntracerebral hemorrhageRandomized trialsUnadjusted analysesClinical trialsEligible studiesAncillary studiesObservational studyPooled estimatesGeneral populationSystematic reviewUnadjusted probabilitySystematic searchCross-sectional dataCombining Imaging and Genetics to Predict Recurrence of Anticoagulation-Associated Intracerebral Hemorrhage
Biffi A, Urday S, Kubiszewski P, Gilkerson L, Sekar P, Rodriguez-Torres A, Bettin M, Charidimou A, Pasi M, Kourkoulis C, Schwab K, DiPucchio Z, Behymer T, Osborne J, Morgan M, Moomaw CJ, James ML, Greenberg SM, Viswanathan A, Gurol ME, Worrall BB, Testai FD, McCauley JL, Falcone GJ, Langefeld CD, Anderson CD, Kamel H, Woo D, Sheth KN, Rosand J. Combining Imaging and Genetics to Predict Recurrence of Anticoagulation-Associated Intracerebral Hemorrhage. Stroke 2020, 51: 2153-2160. PMID: 32517581, PMCID: PMC7311289, DOI: 10.1161/strokeaha.120.028310.Peer-Reviewed Original ResearchConceptsCortical superficial siderosisICH recurrenceCerebral microbleedsSuperficial siderosisIntracerebral hemorrhageRecurrent ICHMRI markersOral anticoagulation therapyPotent risk factorRecurrent hemorrhagic strokeLongitudinal cohort studyLow-risk categoryLow-risk individualsΕ2/ε4ICH survivorsAnticoagulation therapyCohort studyHemorrhagic strokeProspective studyRecurrence rateΕ4 variantRisk factorsClinical impactERICH studyΕ4 allele
2013
Apolipoprotein E, Statins, and Risk of Intracerebral Hemorrhage
Woo D, Deka R, Falcone GJ, Flaherty ML, Haverbusch M, Martini SR, Greenberg SM, Ayres AM, Sauerbeck L, Kissela BM, Kleindorfer DO, Moomaw CJ, Anderson CD, Broderick JP, Rosand J, Langefeld CD, Woo JG. Apolipoprotein E, Statins, and Risk of Intracerebral Hemorrhage. Stroke 2013, 44: 3013-3017. PMID: 24008570, PMCID: PMC3873717, DOI: 10.1161/strokeaha.113.001304.Peer-Reviewed Original ResearchConceptsRisk of ICHLobar intracerebral hemorrhageStatin useIntracerebral hemorrhageReplication cohortICH casesAssociation of hypercholesterolemiaHemorrhagic Stroke studyNonlobar intracerebral hemorrhageCase-control studyApolipoprotein E genotypeFisher's exact testEnvironmental risk factorsBreslow-Day testHemorrhagic strokeStroke StudyRisk factorsClinical changesE4 genotypeAPOE polymorphismE genotypeApolipoprotein EDiscovery cohortHigh riskLower risk