2021
Andexanet Alfa Versus 4-Factor Prothrombin Complex Concentrate for Reversal of Factor Xa Inhibitors in Intracranial Hemorrhage
Ammar AA, Ammar MA, Owusu KA, Brown SC, Kaddouh F, Elsamadicy AA, Acosta JN, Falcone GJ. Andexanet Alfa Versus 4-Factor Prothrombin Complex Concentrate for Reversal of Factor Xa Inhibitors in Intracranial Hemorrhage. Neurocritical Care 2021, 35: 255-261. PMID: 33403588, PMCID: PMC10273779, DOI: 10.1007/s12028-020-01161-5.Peer-Reviewed Original ResearchConceptsFactor Xa inhibitorsSpontaneous intracranial hemorrhageSpontaneous intraparenchymal hemorrhageAndexanet alfaIntracranial hemorrhageProthrombin complex concentrateThrombotic eventsIntraparenchymal hemorrhageFunctional outcomeComplex concentrateXa inhibitorsFour-factor prothrombin complex concentrateOnset of ICHConsecutive adult patientsGood functional outcomeModified Rankin scoreSubgroup of patientsNumber of patientsThromboembolic eventsRankin scoreAdult patientsMedian ageRetrospective reviewHematoma volumeResultsA total
2020
Direct carotid puncture for mechanical thrombectomy in acute ischemic stroke patients with prohibitive vascular access.
Cord BJ, Kodali S, Strander S, Silverman A, Wang A, Chouairi F, Koo AB, Nguyen CK, Peshwe K, Kimmel A, Porto CM, Hebert RM, Falcone GJ, Sheth KN, Sansing LH, Schindler JL, Matouk CC, Petersen NH. Direct carotid puncture for mechanical thrombectomy in acute ischemic stroke patients with prohibitive vascular access. Journal Of Neurosurgery 2020, 135: 53-63. PMID: 32796146, PMCID: PMC9491727, DOI: 10.3171/2020.5.jns192737.Peer-Reviewed Original ResearchDirect carotid punctureSmaller infarct volumesMechanical thrombectomyVascular accessFunctional outcomeAIS-LVONIHSS scoreDCP groupInfarct volumeTransfemoral accessNeck hematomaStroke patientsCarotid punctureABMT groupAnterior circulation acute ischemic strokeCommon carotid artery dissectionAcute ischemic stroke patientsDirect carotid accessEmergency mechanical thrombectomyAcute ischemic strokeAdmission NIHSS scoreCarotid artery dissectionIschemic stroke patientsGood functional outcomeLarge vessel occlusionRace/ethnicity influences outcomes in young adults with supratentorial intracerebral hemorrhage.
Miyares LC, Falcone GJ, Leasure A, Adeoye O, Shi FD, Kittner SJ, Langefeld C, Vagal A, Sheth KN, Woo D. Race/ethnicity influences outcomes in young adults with supratentorial intracerebral hemorrhage. Neurology 2020, 94: e1271-e1280. PMID: 31969467, PMCID: PMC7274930, DOI: 10.1212/wnl.0000000000008930.Peer-Reviewed Original ResearchConceptsSupratentorial intracerebral hemorrhageModified Rankin ScaleIntracerebral hemorrhageRace/ethnicityFunctional outcomeYounger patientsPoor outcomeAdmission Glasgow Coma Scale scoreEthnic/Racial VariationsGlasgow Coma Scale scoreHispanic participantsHispanic race/ethnicityAdmission blood pressureDeep ICH locationIntracerebral Hemorrhage (ERICH) studyProspective multicenter studyGood functional outcomeNon-Hispanic blacksBaseline disabilityRankin ScaleBlood pressureICH locationIntraventricular extensionMulticenter studyICH volume