2021
Obeticholic Acid Decreases Intestinal Content of Enterococcus in Rats With Cirrhosis and Ascites
Yan K, Hung A, Parmer C, Yang H, Jain D, Lim B, Goodman AL, Garcia‐Tsao G. Obeticholic Acid Decreases Intestinal Content of Enterococcus in Rats With Cirrhosis and Ascites. Hepatology Communications 2021, 5: 1507-1517. PMID: 34510838, PMCID: PMC8435275, DOI: 10.1002/hep4.1740.Peer-Reviewed Original ResearchHigher serum albuminBacterial translocationObeticholic acidEnd of studyAspartate aminotransferaseLymph nodesIntestinal microbiomeIntestinal contentsSemisynthetic bile acidMesenteric lymph nodesEnd of treatmentCarbon tetrachloride inhalationExtra-intestinal sitesLower aspartate aminotransferaseFurther decompensationLiver injuryLiver functionPolymerase chain reactionExperimental cirrhosisPathogenic bacteriaCirrhosisHepatocyte deathDay 1Bile acidsPlacebo
2018
Su1556 - In Experimental Cirrhosis with Ascites, Obeticholic Acid Reduces Bacterial Translocation to Extra-Intestinal Sites and has a Beneficial Intrahepatic Effect
Hung A, Yan K, Yang H, Jain D, Garcia-Tsao G. Su1556 - In Experimental Cirrhosis with Ascites, Obeticholic Acid Reduces Bacterial Translocation to Extra-Intestinal Sites and has a Beneficial Intrahepatic Effect. Gastroenterology 2018, 154: s-1177. DOI: 10.1016/s0016-5085(18)33897-6.Peer-Reviewed Original Research