2012
Ucp2 Induced by Natural Birth Regulates Neuronal Differentiation of the Hippocampus and Related Adult Behavior
Simon-Areces J, Dietrich MO, Hermes G, Garcia-Segura LM, Arevalo MA, Horvath TL. Ucp2 Induced by Natural Birth Regulates Neuronal Differentiation of the Hippocampus and Related Adult Behavior. PLOS ONE 2012, 7: e42911. PMID: 22905184, PMCID: PMC3414493, DOI: 10.1371/journal.pone.0042911.Peer-Reviewed Original ResearchConceptsUCP2 expressionCellular stressHippocampal neuronsChemical inhibitionMitochondrial bioenergeticsNeuronal differentiationGenetic ablationNatural birthProtein 2Adult behaviorCell proliferationCritical roleAdult brainNeuronal numberExpressionBioenergeticsNeuronsBirthDifferentiationRegulationProliferationSynaptogenesisVitroNeuroprotectionHippocampus
2009
Social isolation dysregulates endocrine and behavioral stress while increasing malignant burden of spontaneous mammary tumors
Hermes GL, Delgado B, Tretiakova M, Cavigelli SA, Krausz T, Conzen SD, McClintock MK. Social isolation dysregulates endocrine and behavioral stress while increasing malignant burden of spontaneous mammary tumors. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 22393-22398. PMID: 20018726, PMCID: PMC2799783, DOI: 10.1073/pnas.0910753106.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AnimalBreast NeoplasmsCarcinoma, Ductal, BreastCarcinoma, Intraductal, NoninfiltratingCorticosteroneEndocrine GlandsFemaleHumansMammary Neoplasms, ExperimentalOvaryRatsRats, Sprague-DawleyReceptors, GlucocorticoidRisk FactorsSocial EnvironmentSocial IsolationStress, PhysiologicalStress, PsychologicalConceptsDuctal carcinomaBreast cancerCorticosterone responseTumor developmentMammary tumor burdenProgesterone receptor statusEarly breast cancerMammary tumor growthInvasive ductal carcinomaSprague-Dawley ratsMammary tumor progressionAge-matched controlsSpontaneous mammary tumorsLife Span StudyMalignant burdenTumor estrogenReceptor statusTumor burdenOvarian functionFemale ratsMammary tumorsRelative riskTumor growthPsychosocial stressorsTumor progression
2008
Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection
Hermes G, Ajioka JW, Kelly KA, Mui E, Roberts F, Kasza K, Mayr T, Kirisits MJ, Wollmann R, Ferguson D, Roberts CW, Hwang JH, Trendler T, Kennan RP, Suzuki Y, Reardon C, Hickey WF, Chen L, McLeod R. Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection. Journal Of Neuroinflammation 2008, 5: 48. PMID: 18947414, PMCID: PMC2588578, DOI: 10.1186/1742-2094-5-48.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnimalsAtrophyBehavior, AnimalBiomarkersBrainCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesChronic DiseaseDisease Models, AnimalEncephalitisFemaleLateral VentriclesMagnetic Resonance ImagingMiceMicrogliaNerve DegenerationNerve Tissue ProteinsNeuronsToxoplasmaToxoplasmosis, CerebralConceptsT. gondii infectionAqueduct of SylviusPerivascular inflammationVentricular dilatationGondii infectionResistant miceInflammatory cellsBrain weightBrain parenchymaBrain MRIBehavioral abnormalitiesChronic T. gondii infectionLower brain weightPersistent brain infectionBrains of micePD-1LResultsTwelve monthsNeurologic findingsNeurological deficitsNeuronal injuryStudy of markersNeurologic functionNeuronal damageBrain infectionFree tachyzoites