2022
ABCB1 variants and sex affect serotonin transporter occupancy in the brain
Silberbauer LR, Rischka L, Vraka C, Hartmann AM, Godbersen GM, Philippe C, Pacher D, Nics L, Klöbl M, Unterholzner J, Stimpfl T, Wadsak W, Hahn A, Hacker M, Rujescu D, Kasper S, Lanzenberger R, Gryglewski G. ABCB1 variants and sex affect serotonin transporter occupancy in the brain. Molecular Psychiatry 2022, 27: 4502-4509. PMID: 36071112, PMCID: PMC7613909, DOI: 10.1038/s41380-022-01733-1.Peer-Reviewed Original ResearchConceptsMinor allele carriersTransporter occupancyAllele carriersABCB1 single nucleotide polymorphismsBasic clinical variablesCitalopram plasma concentrationsYears of ageMajor allele homozygotesCross-over designPET/MRISERT occupancyClinical variablesTreatment promisesClinical algorithmMajor depressionPlasma concentrationsPrecision pharmacotherapyABCB1 variantsHealthy volunteersABCB1 geneAllele homozygotesSame dosageDrug-target engagementTarget engagementSingle nucleotide polymorphisms
2014
(S)-citalopram influences amygdala modulation in healthy subjects: a randomized placebo-controlled double-blind fMRI study using dynamic causal modeling
Sladky R, Spies M, Hoffmann A, Kranz G, Hummer A, Gryglewski G, Lanzenberger R, Windischberger C, Kasper S. (S)-citalopram influences amygdala modulation in healthy subjects: a randomized placebo-controlled double-blind fMRI study using dynamic causal modeling. NeuroImage 2014, 108: 243-250. PMID: 25536499, DOI: 10.1016/j.neuroimage.2014.12.044.Peer-Reviewed Original ResearchConceptsOrbitofrontal cortexDynamic causal modelingHealthy subjectsDouble-blind fMRI studyCortico-limbic circuitsMagnetic resonance imaging (MRI) scanningAmygdala activationDouble-blind designPharmaceutical treatment optionsFunctional magnetic resonance imaging (fMRI) scanningEmotional face discrimination taskAmygdala modulationNeurophysiologic functionTreatment optionsPsychiatric disordersModulatory effectsCitalopramFunctional MRI dataEscitalopramDiscrimination taskEffective connectivity methodsFMRI studyRegulatory effectsEffective connectivityDifferential effects