Striatal dopaminergic alterations in Tourette’s syndrome: a meta-analysis based on 16 PET and SPECT neuroimaging studies
Hienert M, Gryglewski G, Stamenkovic M, Kasper S, Lanzenberger R. Striatal dopaminergic alterations in Tourette’s syndrome: a meta-analysis based on 16 PET and SPECT neuroimaging studies. Translational Psychiatry 2018, 8: 143. PMID: 30072700, PMCID: PMC6072751, DOI: 10.1038/s41398-018-0202-y.Peer-Reviewed Original ResearchConceptsTourette patientsTourette syndromeDopamine transporterDopaminergic alterationsDopamine systemCurrent pathophysiological hypothesesStriatal dopaminergic alterationsStriatal dopamine receptorsStudy population characteristicsStriatal dopamine transporterStriatal dopamine functionFree patientsHealthy controlsPathophysiological hypothesesDopamine receptorsMolecular imaging studiesNonsignificant trendDopamine functionPatientsSPECT studiesSystematic reviewImaging studiesSyndromeNeuroimaging studiesReceptor binding