2010
Evaluation of Cerebral Acetate Transport and Metabolic Rates in the Rat Brain in vivo Using 1H-[13C]-NMR
Patel AB, de Graaf RA, Rothman DL, Behar KL, Mason GF. Evaluation of Cerebral Acetate Transport and Metabolic Rates in the Rat Brain in vivo Using 1H-[13C]-NMR. Cerebrovascular And Brain Metabolism Reviews 2010, 30: 1200-1213. PMID: 20125180, PMCID: PMC2879471, DOI: 10.1038/jcbfm.2010.2.Peer-Reviewed Original Research
2006
Increased Brain Monocarboxylic Acid Transport and Utilization in Type 1 Diabetes
Mason GF, Petersen KF, Lebon V, Rothman DL, Shulman GI. Increased Brain Monocarboxylic Acid Transport and Utilization in Type 1 Diabetes. Diabetes 2006, 55: 929-934. PMID: 16567513, PMCID: PMC2995526, DOI: 10.2337/diabetes.55.04.06.db05-1325.Peer-Reviewed Original ResearchConceptsType 1 diabetesDiabetic subjectsControl subjectsType 1 diabetic subjectsInsulin-induced hypoglycemiaNondiabetic control subjectsMonocarboxylic acid transportBrain utilizationSimilar twofold increaseBrain energeticsHypoglycemiaType 1DiabetesOxidative metabolismNonglucose substratesBrainMetabolic substratesUpregulationPatientsAcid transportTwofold increaseSubjectsMagnetic resonance spectroscopyLactateMetabolism
2001
In vivo13C NMR measurement of neurotransmitter glutamate cycling, anaplerosis and TCA cycle flux in rat brain during [2‐13C]glucose infusion
Sibson N, Mason G, Shen J, Cline G, Herskovits A, Wall J, Behar K, Rothman D, Shulman R. In vivo13C NMR measurement of neurotransmitter glutamate cycling, anaplerosis and TCA cycle flux in rat brain during [2‐13C]glucose infusion. Journal Of Neurochemistry 2001, 76: 975-989. PMID: 11181817, DOI: 10.1046/j.1471-4159.2001.00074.x.Peer-Reviewed Original ResearchConceptsGlutamate/glutamine cyclingCerebral cortexAstrocytic tricarboxylic acid cycleGlutamine cyclingRat cerebral cortexGlutamine synthesisDe novo glutamine synthesisAnesthetized ratsRat brainNeurotransmitter glutamateHyperammonemic conditionsGlutamate cyclingInfusionGlutamate precursorCortexBrainTCA cycle fluxAnaplerosisMajor metabolic fluxTricarboxylic acid cycleCycle flux