1998
Lateralization of human temporal lobe epilepsy by 31P NMR spectroscopic imaging at 4.1 T
Chu W, Hetherington H, Kuzniecky R, Simor T, Mason G, Elgavish G. Lateralization of human temporal lobe epilepsy by 31P NMR spectroscopic imaging at 4.1 T. Neurology 1998, 51: 472-479. PMID: 9710021, DOI: 10.1212/wnl.51.2.472.Peer-Reviewed Original ResearchConceptsMesial temporal lobeTemporal lobe epilepsy patientsTemporal lobe epilepsyPCr/PiTemporal lobeClinical lateralizationLobe epilepsySeizure focusEpilepsy patientsHealthy volunteersHuman temporal lobe epilepsyPi ratioSubgroup of patientsIpsilateral lobePresurgical lateralizationContralateral lobeLateralization resultsPatientsMetabolite ratiosNoninvasive modalityNoninvasive methodLateralizationScalp EEGAnterior regionIntracranial EEGStoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity
Sibson N, Dhankhar A, Mason G, Rothman D, Behar K, Shulman R. Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 316-321. PMID: 9419373, PMCID: PMC18211, DOI: 10.1073/pnas.95.1.316.Peer-Reviewed Original ResearchConceptsGlutamatergic neuronal activityGlutamate neurotransmitter cyclingNeuronal activityGln synthesisBrain glucose metabolismSynaptic glutamate releaseGlc metabolismGlutamate releaseRat cortexSynaptic activityGlucose metabolismNeuronal functionBrain activation studiesTricarboxylic acid cycleCortexMetabolismAcid cycleActivation studiesAstrocytesNeuronsActivity
1995
Proton nuclear magnetic resonance spectroscopic imaging of human temporal lobe epilepsy at 4.1 T
Hetherington H, Kuzniecky R, Pan J, Mason G, Morawetz R, Harris C, Faught E, Vaughan T, Pohost G. Proton nuclear magnetic resonance spectroscopic imaging of human temporal lobe epilepsy at 4.1 T. Annals Of Neurology 1995, 38: 396-404. PMID: 7668825, DOI: 10.1002/ana.410380309.Peer-Reviewed Original ResearchMeSH KeywordsAdultAspartic AcidCholineCreatineElectroencephalographyEpilepsy, Temporal LobeFemaleHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaleProtonsConceptsTemporal lobe epilepsyMagnetic resonance spectroscopic imagingProton magnetic resonance spectroscopic imagingLobe epilepsyAcetylaspartate ratioMetabolic abnormalitiesEpileptic focusBilateral independent seizure onsetHuman temporal lobe epilepsyIntractable temporal lobe epilepsyIntracranial electroencephalographic studiesOperated temporal lobeNormal control subjectsDistinctive metabolic profileMagnetic resonance imagingContralateral abnormalitiesControl subjectsSeizure onsetCholine levelsHealthy volunteersN-acetylaspartateTemporal lobePatientsEpilepsyResonance imaging