2010
Evaluation of Cerebral Acetate Transport and Metabolic Rates in the Rat Brain in vivo Using 1H-[13C]-NMR
Patel AB, de Graaf RA, Rothman DL, Behar KL, Mason GF. Evaluation of Cerebral Acetate Transport and Metabolic Rates in the Rat Brain in vivo Using 1H-[13C]-NMR. Cerebrovascular And Brain Metabolism Reviews 2010, 30: 1200-1213. PMID: 20125180, PMCID: PMC2879471, DOI: 10.1038/jcbfm.2010.2.Peer-Reviewed Original Research
2009
Altered Brain Mitochondrial Metabolism in Healthy Aging as Assessed by in vivo Magnetic Resonance Spectroscopy
Boumezbeur F, Mason GF, de Graaf RA, Behar KL, Cline GW, Shulman GI, Rothman DL, Petersen KF. Altered Brain Mitochondrial Metabolism in Healthy Aging as Assessed by in vivo Magnetic Resonance Spectroscopy. Cerebrovascular And Brain Metabolism Reviews 2009, 30: 211-221. PMID: 19794401, PMCID: PMC2949111, DOI: 10.1038/jcbfm.2009.197.Peer-Reviewed Original ResearchConceptsNeuronal mitochondrial metabolismHealthy agingBrain mitochondrial metabolismElderly subjectsYoung subjectsBrain functionBrain mitochondrial functionGlutamate-glutamine cyclingMitochondrial metabolismVivo magnetic resonance spectroscopyAge-related changesChronic reductionLabeling of glutamineGlutamate concentrationYoung volunteersBiologic basisMagnetic resonance spectroscopyMitochondrial functionMetabolismSubjectsIndividual subjectsResonance spectroscopyTricarboxylic acid cycleCycle fluxAging
2001
In vivo13C NMR measurement of neurotransmitter glutamate cycling, anaplerosis and TCA cycle flux in rat brain during [2‐13C]glucose infusion
Sibson N, Mason G, Shen J, Cline G, Herskovits A, Wall J, Behar K, Rothman D, Shulman R. In vivo13C NMR measurement of neurotransmitter glutamate cycling, anaplerosis and TCA cycle flux in rat brain during [2‐13C]glucose infusion. Journal Of Neurochemistry 2001, 76: 975-989. PMID: 11181817, DOI: 10.1046/j.1471-4159.2001.00074.x.Peer-Reviewed Original ResearchConceptsGlutamate/glutamine cyclingCerebral cortexAstrocytic tricarboxylic acid cycleGlutamine cyclingRat cerebral cortexGlutamine synthesisDe novo glutamine synthesisAnesthetized ratsRat brainNeurotransmitter glutamateHyperammonemic conditionsGlutamate cyclingInfusionGlutamate precursorCortexBrainTCA cycle fluxAnaplerosisMajor metabolic fluxTricarboxylic acid cycleCycle flux
1994
Detection of brain glutamate and glutamine in spectroscopic images at 4.1 T
Mason G, Pan J, Ponder S, Twieg D, Pohost G, Hetherington H. Detection of brain glutamate and glutamine in spectroscopic images at 4.1 T. Magnetic Resonance In Medicine 1994, 32: 142-145. PMID: 7916115, DOI: 10.1002/mrm.1910320121.Peer-Reviewed Original Research
1992
NMR Determination of the TCA Cycle Rate and α-Ketoglutarate/Glutamate Exchange Rate in Rat Brain
Mason G, Rothman D, Behar K, Shulman R. NMR Determination of the TCA Cycle Rate and α-Ketoglutarate/Glutamate Exchange Rate in Rat Brain. Cerebrovascular And Brain Metabolism Reviews 1992, 12: 434-447. PMID: 1349022, DOI: 10.1038/jcbfm.1992.61.Peer-Reviewed Original ResearchNMR Determination of Intracerebral Glucose Concentration and Transport Kinetics in Rat Brain
Mason G, Behar K, Rothman D, Shulman R. NMR Determination of Intracerebral Glucose Concentration and Transport Kinetics in Rat Brain. Cerebrovascular And Brain Metabolism Reviews 1992, 12: 448-455. PMID: 1569138, DOI: 10.1038/jcbfm.1992.62.Peer-Reviewed Original Research