2023
Cortical GABA Levels Are Reduced in Post-Acute COVID-19 Syndrome
Marinkovic K, White D, Myers A, Parker K, Arienzo D, Mason G. Cortical GABA Levels Are Reduced in Post-Acute COVID-19 Syndrome. Brain Sciences 2023, 13: 1666. PMID: 38137114, PMCID: PMC10741691, DOI: 10.3390/brainsci13121666.Peer-Reviewed Original ResearchAcute COVID-19 illnessCOVID-19 illnessGABA levelsN-acetylaspartatePost-acute COVID-19 syndromeCortical GABA levelsPersistent cognitive dysfunctionPost-acute sequelaeCOVID-19 syndromeExcitation/inhibition imbalancePoor sleep qualityProton magnetic resonance spectroscopyDepression/anxietyQuality of lifePersistent neuroinflammationBrain fogCortical hyperexcitabilityLong COVIDAlcohol intakeCognitive dysfunctionNeuronal integrityNeurocognitive dysfunctionNeurochemical aspectsSleep qualityOccipital cortex
2017
Metabotropic Glutamate Receptor 5 and Glutamate Involvement in Major Depressive Disorder: A Multimodal Imaging Study
Abdallah CG, Hannestad J, Mason GF, Holmes SE, DellaGioia N, Sanacora G, Jiang L, Matuskey D, Satodiya R, Gasparini F, Lin X, Javitch J, Planeta B, Nabulsi N, Carson RE, Esterlis I. Metabotropic Glutamate Receptor 5 and Glutamate Involvement in Major Depressive Disorder: A Multimodal Imaging Study. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2017, 2: 449-456. PMID: 28993818, PMCID: PMC5630181, DOI: 10.1016/j.bpsc.2017.03.019.Peer-Reviewed Original ResearchMajor depressive disorderMetabotropic glutamate receptor 5Positron emission tomographyGlutamate receptor 5Healthy controlsGlx levelsMGluR5 availabilityDepressive disorderReceptor 5Glx/Cr levelsAnterior cingulate glutamateGlutamate/CrRole of mGluR5Proton magnetic resonance spectroscopyDistribution volume ratioMultimodal Imaging StudyACC glutamateGlutamatergic systemGlutamate involvementGlutamate levelsPostmortem studiesEmission tomographyImaging studiesMGluR5Cr levels
2011
Intravenous Ethanol Infusion Decreases Human Cortical γ-Aminobutyric Acid and N-Acetylaspartate as Measured with Proton Magnetic Resonance Spectroscopy at 4 Tesla
Gomez R, Behar KL, Watzl J, Weinzimer SA, Gulanski B, Sanacora G, Koretski J, Guidone E, Jiang L, Petrakis IL, Pittman B, Krystal JH, Mason GF. Intravenous Ethanol Infusion Decreases Human Cortical γ-Aminobutyric Acid and N-Acetylaspartate as Measured with Proton Magnetic Resonance Spectroscopy at 4 Tesla. Biological Psychiatry 2011, 71: 239-246. PMID: 21855054, PMCID: PMC3227760, DOI: 10.1016/j.biopsych.2011.06.026.Peer-Reviewed Original ResearchConceptsIntravenous ethanol infusionProton magnetic resonance spectroscopyEthanol infusionNAA levelsN-acetylaspartateCortical γ-aminobutyric acidAcute pharmacologic effectsLevels of GABAHealthy social drinkersBreath alcohol levelsN-acetylaspartyl-glutamateCortical GABAEthanol modulatesFirst infusionΓ-aminobutyric acidGABA levelsPharmacologic effectsBrain ethanolOccipital GABAInfusionAlcohol levelsMagnetic resonance spectroscopyReceptor functionBreath ethanolHuman cortex