2020
Impaired neuronal and astroglial metabolic activity in chronic unpredictable mild stress model of depression: Reversal of behavioral and metabolic deficit with lanicemine
Mishra PK, Adusumilli M, Deolal P, Mason GF, Kumar A, Patel AB. Impaired neuronal and astroglial metabolic activity in chronic unpredictable mild stress model of depression: Reversal of behavioral and metabolic deficit with lanicemine. Neurochemistry International 2020, 137: 104750. PMID: 32360130, DOI: 10.1016/j.neuint.2020.104750.Peer-Reviewed Original ResearchConceptsChronic unpredictable mild stressCUMS micePrefrontal cortexChronic unpredictable mild stress (CUMS) modelNeurotransmitter cyclingThree-compartment metabolic modelUnpredictable mild stressCause of disabilityNMDA receptor antagonistPotential therapeutic roleMajor depressive disorderAstrocytic TCA cycleNeural metabolic activityMetabolic activityGABAergic neuronsInhibitory neurotransmissionReceptor antagonistSwim testSucrose preferenceC57BL6 miceDepressive disorderTherapeutic roleChronic depressionGlutamatergic pathwaysMetabolic deficits
2010
Regional metabolite levels and turnover in the awake rat brain under the influence of nicotine
Wang J, Jiang L, Jiang Y, Ma X, Chowdhury GM, Mason GF. Regional metabolite levels and turnover in the awake rat brain under the influence of nicotine. Journal Of Neurochemistry 2010, 113: 1447-1458. PMID: 20345764, PMCID: PMC2903655, DOI: 10.1111/j.1471-4159.2010.06684.x.Peer-Reviewed Original ResearchConceptsRat brainN-acetylaspartateAcute nicotine treatmentBrain glucose oxidationAmino acid neurotransmittersInfluence of nicotineConcentration of glutamateRegional metabolite levelsAwake rat brainRelated neurochemicalsNicotine treatmentInhibitory neurotransmissionAcute effectsOlfactory bulbOccipital cortexNeurotransmitter cyclingGABA synthesisNicotineStriatumBrainMetabolite levelsWidespread drugGABACortexPotential interplay