2006
IL-10-deficiency unmasks unique immune system defects and reveals differential regulation of organ-specific autoimmunity in non-obese diabetic mice
Rajagopalan G, Kudva Y, Sen M, Marietta E, Murali N, Nath K, Moore J, David C. IL-10-deficiency unmasks unique immune system defects and reveals differential regulation of organ-specific autoimmunity in non-obese diabetic mice. Cytokine 2006, 34: 85-95. PMID: 16740391, DOI: 10.1016/j.cyto.2006.04.006.Peer-Reviewed Original ResearchConceptsOrgan-specific autoimmunityComplete Freund's adjuvantNOD miceRectal prolapseToll-like receptor 9 agonistSystemic inflammatory cytokine responsesTh1-type autoimmune diseaseNon-obese diabetic (NOD) micePotent anti-inflammatory cytokineCyclophosphamide-induced diabetesDiabetic NOD miceIL-10 deficiencyAnti-inflammatory cytokinesReceptor 9 agonistInflammatory cytokine responseImmune system defectsType 1 diabetesPathogen-free conditionsSplenic macrophage numbersAdoptive transferIL-10Cytokine responsesDiabetic miceFreund's adjuvantAutoimmune diseases
2002
Modulation of insulitis and type 1 diabetes by transgenic HLA-DR3 and DQ8 in NOD mice lacking endogenous MHC class II
Kudva Y, Rajagopalan G, Raju R, Abraham R, Smart M, Hanson J, David C. Modulation of insulitis and type 1 diabetes by transgenic HLA-DR3 and DQ8 in NOD mice lacking endogenous MHC class II. Human Immunology 2002, 63: 987-999. PMID: 12392851, DOI: 10.1016/s0198-8859(02)00435-4.Peer-Reviewed Original ResearchConceptsType 1 diabetesEndogenous class II moleculesClass II moleculesHLA-DR3NOD miceHuman leukocyte antigen (HLA) transgenic miceTransgenic miceEndogenous MHC class IICyclophosphamide-induced diabetesIntra-islet infiltrationMultiple low dosesDouble transgenic miceGroups of miceMHC class IINonobese diabetic (NOD) backgroundTransgenic expressionSpontaneous diabetesDiabetic backgroundUnmanipulated miceDQ8DiabetesLow dosesClass IILess infiltrationMice