2024
A confounder controlled machine learning approach: Group analysis and classification of schizophrenia and Alzheimer’s disease using resting-state functional network connectivity
Hassanzadeh R, Abrol A, Pearlson G, Turner J, Calhoun V. A confounder controlled machine learning approach: Group analysis and classification of schizophrenia and Alzheimer’s disease using resting-state functional network connectivity. PLOS ONE 2024, 19: e0293053. PMID: 38768123, PMCID: PMC11104643, DOI: 10.1371/journal.pone.0293053.Peer-Reviewed Original ResearchConceptsResting-state functional network connectivityFunctional network connectivityResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingAlzheimer's diseaseClassification of schizophreniaNetwork pairsPatients to healthy controlsSchizophrenia patientsNeurobiological mechanismsSZ patientsSubcortical networksCerebellum networkSchizophreniaRs-fMRIDisorder developmentMotor networkCompare patient groupsSubcortical domainSZ disorderHealthy controlsMagnetic resonance imagingDisordersNetwork connectivityFunctional abnormalities
2014
Multivariate analysis reveals genetic associations of the resting default mode network in psychotic bipolar disorder and schizophrenia
Meda SA, Ruaño G, Windemuth A, O’Neil K, Berwise C, Dunn SM, Boccaccio LE, Narayanan B, Kocherla M, Sprooten E, Keshavan MS, Tamminga CA, Sweeney JA, Clementz BA, Calhoun VD, Pearlson GD. Multivariate analysis reveals genetic associations of the resting default mode network in psychotic bipolar disorder and schizophrenia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: e2066-e2075. PMID: 24778245, PMCID: PMC4024891, DOI: 10.1073/pnas.1313093111.Peer-Reviewed Original ResearchConceptsDefault mode networkPsychotic bipolar disorderUnaffected first-degree relativesFirst-degree relativesSZ probandsResting-state functional MRI scansBipolar disorderMode networkFunctional MRI scansLong-term potentiationBrain's default mode networkGlobal enrichment analysisSubset of controlsPatient groupHealthy controlsDMN modulationDrug treatmentImmune responsePsychiatric disordersStudy subjectsMRI scansDMN connectivityMultivariate analysisFunctional connectivitySchizophrenia
2010
Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional–executive network function in Alzheimer’s disease
Wolk D, Dickerson B, Weiner M, Aiello M, Aisen P, Albert M, Alexander G, Anderson H, Anderson K, Apostolova L, Arnold S, Ashford W, Assaly M, Asthana S, Bandy D, Bartha R, Bates V, Beckett L, Bell K, Benincasa A, Bergman H, Bernick C, Bernstein M, Black S, Blank K, Borrie M, Brand C, Brewer J, Brown A, Burns J, Cairns N, Caldwell C, Capote H, Carlsson C, Carmichael O, Cellar J, Celmins D, Chen K, Chertkow H, Chowdhury M, Clark D, Connor D, Correia S, Crawford K, Dale A, de Leon M, De Santi S, DeCarli C, deToledo-Morrell L, DeVous M, Diaz-Arrastia R, Dolen S, Donohue M, Doody R, Doraiswamy P, Duara R, Englert J, Farlow M, Feldman H, Felmlee J, Fleisher A, Fletcher E, Foroud T, Foster N, Fox N, Frank R, Gamst A, Given C, Graff-Radford N, Green R, Griffith R, Grossman H, Hake A, Hardy P, Harvey D, Heidebrink J, Hendin B, Herring S, Honig L, Hosein C, Hsiung G, Hudson L, Ismail M, Jack C, Jacobson S, Jagust W, Jayam-Trouth A, Johnson K, Johnson H, Johnson N, Johnson K, Johnson K, Johnson S, Kachaturian Z, Karlawish J, Kataki M, Kaye J, Kertesz A, Killiany R, Kittur S, Koeppe R, Korecka M, Kornak J, Kozauer N, Lah J, Laubinger M, Lee V, Lee T, Lerner A, Levey A, Longmire C, Lopez O, Lord J, Lu P, MacAvoy M, Malloy P, Marson D, Martin-Cook K, Martinez W, Marzloff G, Mathis C, Mc-Adams-Ortiz C, Mesulam M, Miller B, Mintun M, Mintzer J, Molchan S, Montine T, Morris J, Mulnard R, Munic D, Nair A, Neu S, Nguyen D, Norbash A, Oakley M, Obisesan T, Ogrocki P, Ott B, Parfitt F, Pawluczyk S, Pearlson G, Petersen R, Petrella J, Potkin S, Potter W, Preda A, Quinn J, Rainka M, Reeder S, Reiman E, Rentz D, Reynolds B, Richard J, Roberts P, Rogers J, Rosen A, Rosen H, Rusinek H, Sabbagh M, Sadowsky C, Salloway S, Santulli R, Saykin A, Scharre D, Schneider L, Schneider S, Schuff N, Shah R, Shaw L, Shen L, Silverman D, Simpson D, Sink K, Smith C, Snyder P, Spann B, Sperling R, Spicer K, Stefanovic B, Stern Y, Stopa E, Tang C, Tariot P, Taylor-Reinwald L, Thai G, Thomas R, Thompson P, Tinklenberg J, Toga A, Tremont G, Trojanowki J, Trost D, Turner R, van Dyck C, Vanderswag H, Varon D, Villanueva-Meyer J, Villena T, Walter S, Wang P, Watkins F, Weiner M, Williamson J, Wolk D, Wu C, Zerrate M, Zimmerman. E. Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional–executive network function in Alzheimer’s disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 10256-10261. PMID: 20479234, PMCID: PMC2890481, DOI: 10.1073/pnas.1001412107.Peer-Reviewed Original ResearchConceptsMedial temporal lobe pathologyLarge-scale brain networksParticular cognitive domainsDomains of cognitionSpecific large-scale brain networksTemporal lobe pathologyDisease Neuroimaging InitiativeMild Alzheimer's diseaseExecutive controlLexical accessCognitive processesCognitive dissociationCognitive domainsDissociable effectsRegional cortical atrophyPoor memoryNeuroanatomic findingsPerformance deficitsMemory retentionBrain networksPotential confoundsCortical networksPsychometric testsRegional brain atrophyGreater impairment