1998
Brain changes in schizophrenia
Sharma T, Lancaster E, Lee D, Lewis S, Sigmundsson T, Takei N, Gurling H, Barta P, Pearlson G, Murray R. Brain changes in schizophrenia. The British Journal Of Psychiatry 1998, 173: 132-138. PMID: 9850225, DOI: 10.1192/bjp.173.2.132.Peer-Reviewed Original ResearchConceptsLarger lateral ventriclesControl subjectsUnrelated control subjectsLateral ventricleSmaller whole brainLateral ventricular enlargementStructural brain abnormalitiesNormal control subjectsObligate carriersGenetic liabilityVentricular enlargementSample of peopleBrain abnormalitiesBrain changesWhole brainCerebellar volumeBrain structuresMagnetic resonance imagesSchizophreniaVentricleUnaffected siblingsReconstructed magnetic resonance imagesResonance imagesAbnormalitiesVolumetric measurements
1997
Small planum temporale volume in Down's syndrome: a volumetric MRI study
Frangou S, Aylward E, Warren A, Sharma T, Barta P, Pearlson G. Small planum temporale volume in Down's syndrome: a volumetric MRI study. American Journal Of Psychiatry 1997, 154: 1424-1429. PMID: 9326826, DOI: 10.1176/ajp.154.10.1424.Peer-Reviewed Original ResearchConceptsPlanum temporale volumeSuperior temporal gyrusDown syndromeTemporal gyrusSyndrome patientsBrain volumePlanum temporaleMagnetic resonance imaging (MRI) measuresCommunity-dwelling patientsStructural brain abnormalitiesVolumetric MRI studyTotal brain volumeDown syndrome patientsHealthy comparison subjectsWhole brain volumeVolumetric magnetic resonance imaging (MRI) measuresAnatomic substrateBrain abnormalitiesHealthy subjectsComparison subjectsMRI studiesVolume deficitsSyndromeGyrusImaging measures
1996
Exploratory factor analysis of MRI brain structure measures in schizophrenia
Tien A, Eaton W, Schlaepfer T, McGilchrist I, Menon R, Richard P, Aylward E, Barta P, Strauss M, Pearlson G. Exploratory factor analysis of MRI brain structure measures in schizophrenia. Schizophrenia Research 1996, 19: 93-101. PMID: 8789907, DOI: 10.1016/0920-9964(96)88520-3.Peer-Reviewed Original ResearchConceptsSuperior temporal gyrusSchizophrenia groupNormal groupTemporal gyrusStructural brain abnormalitiesLateral temporal lobe structuresBrain volume measuresTemporal lobe structuresSpecific brain regionsPosterior superior temporal gyrusBrain structure measuresBasal gangliaBrain abnormalitiesCortical greyEntorhinal cortexBrain regionsSchizophrenic subjectsNeuropsychiatric dataLobe structuresSchizophreniaSignificant differencesSignificant correlationGray regionGyrusFactor structure
1989
Structural brain CT changes and cognitive deficits in elderly depressives with and without reversible dementia (‘pseudodementia’)*
Pearlson G, Rabins P, Kim W, Speedie L, Moberg P, Burns A, Bascom M. Structural brain CT changes and cognitive deficits in elderly depressives with and without reversible dementia (‘pseudodementia’)*. Psychological Medicine 1989, 19: 573-584. PMID: 2798631, DOI: 10.1017/s003329170002417x.Peer-Reviewed Original ResearchConceptsMini-Mental State ExaminationVentricular brain ratioAD patientsDepressed patientsNormal controlsDSM-III major depressionCognitive deficitsShort-term progressionStructural brain abnormalitiesCranial CT scanProbable Alzheimer's diseaseCT attenuation valuesCT valuesReversible dementiaElderly patientsMost patientsBrain ratioCT attenuation numbersCT changesElderly depressivesBrain abnormalitiesDementia syndromesMajor depressionCT scanPatients