1986
STRUCTURAL BRAIN CORRELATES OF EMOTIONAL DISORDER IN MULTIPLE SCLEROSIS
RABINS P, BROOKS B, O'DONNELL P, PEARLSON G, MOBERG P, JUBELT B, COYLE P, DALOS N, FOLSTEIN M. STRUCTURAL BRAIN CORRELATES OF EMOTIONAL DISORDER IN MULTIPLE SCLEROSIS. Brain 1986, 109: 585-597. PMID: 3730806, DOI: 10.1093/brain/109.4.585.Peer-Reviewed Original ResearchConceptsStable spinal cord injuriesMini-Mental State ExaminationMultiple sclerosisBrain involvementSCI patientsMS patientsDepression scoresMean General Health Questionnaire scoresProgressive multiple sclerosisDefinite multiple sclerosisGeneral Health Questionnaire scoresSpinal cord injuryMean depression scoreStructural brain correlatesCord lesionsFunctional disabilityCord injuryNeurological impairmentCT scanQuestionnaire scoresPatientsState ExaminationCognitive disordersAbnormal rangeOne-year studyCerebral ventricular size and cerebrospinal fluid acetylcholinesterase levels in senile dementia of the Alzheimer type
Pearlson G, Tune L. Cerebral ventricular size and cerebrospinal fluid acetylcholinesterase levels in senile dementia of the Alzheimer type. Psychiatry Research 1986, 17: 23-29. PMID: 3484831, DOI: 10.1016/0165-1781(86)90038-7.Peer-Reviewed Original ResearchConceptsVentricle-brain ratioMini-Mental State ExaminationSenile dementiaComputed tomographyAlzheimer typeCerebrospinal fluid acetylcholinesterase activityLateral ventricle-brain ratiosCerebral ventricular sizeDuration of illnessAChE activityCSF AChE activityDegree of dementiaCerebral atrophyVentricular sizeCT scanDilutional effectState ExaminationCognitive impairmentAcetylcholinesterase levelsRadioenzymatic assayDementiaAcetylcholinesterase activityLaboratory dataPatientsSignificant correlation
1984
NORTRIPTYLINE TREATMENT OF POST-STROKE DEPRESSION: A DOUBLE-BLIND STUDY
Lipsey J, Pearlson G, Robinson R, Rao K, Price T. NORTRIPTYLINE TREATMENT OF POST-STROKE DEPRESSION: A DOUBLE-BLIND STUDY. The Lancet 1984, 323: 297-300. PMID: 6141377, DOI: 10.1016/s0140-6736(84)90356-8.Peer-Reviewed Original ResearchConceptsPost-stroke depressionDouble-blind studyDepression ScaleEfficacy of nortriptylinePlacebo-treated patientsSerum nortriptyline levelsHamilton Depression ScalePresent State ExaminationZung Depression ScaleStroke patientsTherapeutic rangeMajor depressionNortriptyline levelsDemonstrated efficacyState ExaminationPatientsNortriptylineDepressionGreater improvementTreatmentSimilar groupsEfficacyImportant addition