2017
APPLYING MULTIVARIATE TECHNIQUES, INCLUDING PARALLEL ICA TO COMMON COMPLEX PSYCHIATRIC ENDOPHENOTYPES
Pearlson G, Meda, Khadka S, Tamminga C, Keshavan M, Clementz B, Sweeney J, Gershon E, Raskin S, Fallahi C. APPLYING MULTIVARIATE TECHNIQUES, INCLUDING PARALLEL ICA TO COMMON COMPLEX PSYCHIATRIC ENDOPHENOTYPES. European Neuropsychopharmacology 2017, 27: s519. DOI: 10.1016/j.euroneuro.2016.09.636.Peer-Reviewed Original ResearchNeuron differentiationMultiple risk genesState functional MRIMolecular biological pathwaysComplex psychiatric diseasesSynaptic contactsBipolar-Schizophrenia NetworkEnrichment analysisUnivariate analysisMedical disordersIntermediate Phenotypes (B-SNIP) studyPsychiatric diseasesLarger sample sizeDisease riskEEG phenotypesFunctional MRISchizophrenia NetworkState EEG dataElectrophysiological phenotypeInterneuron development
1986
Positron Emission Tomography Reveals Elevated D2 Dopamine Receptors in Drug-Naive Schizophrenics
Wong D, Wagner H, Tune L, Dannals R, Pearlson G, Links J, Tamminga C, Broussolle E, Ravert H, Wilson A, Toung J, Malat J, Williams J, O'Tuama L, Snyder S, Kuhar M, Gjedde A. Positron Emission Tomography Reveals Elevated D2 Dopamine Receptors in Drug-Naive Schizophrenics. Science 1986, 234: 1558-1563. PMID: 2878495, DOI: 10.1126/science.2878495.Peer-Reviewed Original ResearchConceptsD2 dopamine receptorsD2 dopamine receptor densityPositron emission tomographyGroup of patientsDopamine receptor densityDopamine receptorsCaudate nucleusReceptor densityNormal volunteersEmission tomographyDrug-naive schizophrenicsNumber of receptorsMost patientsBasal gangliaNeuroleptic drugsPostmortem studiesBiochemical abnormalitiesPatientsPsychiatric diseasesSchizophreniaReceptorsDrugsVolunteersTomographyGroup