1999
Structural brain imaging in schizophrenia: a selective review
Pearlson G, Marsh L. Structural brain imaging in schizophrenia: a selective review. Biological Psychiatry 1999, 46: 627-649. PMID: 10472416, DOI: 10.1016/s0006-3223(99)00071-2.Peer-Reviewed Original ResearchConceptsStructural neuroimaging studiesRegional brain volume abnormalitiesBrain structuresNeuroimaging studiesLateral ventricular enlargementPathophysiology of schizophreniaAbnormal brain structureBrain volume abnormalitiesComputed tomography studyNeuroanatomic pathologyVentricular enlargementBrain abnormalitiesAnatomic findingsVolume abnormalitiesStructural brainSchizophreniaTomography studySelective reviewAbnormalitiesConsistent evidenceBrainGenetic influencesReviewPathophysiologyFindings
1998
Brain changes in schizophrenia
Sharma T, Lancaster E, Lee D, Lewis S, Sigmundsson T, Takei N, Gurling H, Barta P, Pearlson G, Murray R. Brain changes in schizophrenia. The British Journal Of Psychiatry 1998, 173: 132-138. PMID: 9850225, DOI: 10.1192/bjp.173.2.132.Peer-Reviewed Original ResearchConceptsLarger lateral ventriclesControl subjectsUnrelated control subjectsLateral ventricleSmaller whole brainLateral ventricular enlargementStructural brain abnormalitiesNormal control subjectsObligate carriersGenetic liabilityVentricular enlargementSample of peopleBrain abnormalitiesBrain changesWhole brainCerebellar volumeBrain structuresMagnetic resonance imagesSchizophreniaVentricleUnaffected siblingsReconstructed magnetic resonance imagesResonance imagesAbnormalitiesVolumetric measurements
1985
Symptomatic, Familial, Perinatal, and Social Correlates of Computerized Axial Tomography (CAT) Changes in Schizophrenics and Bipolars
PEARLSON G, GARBACZ D, MOBERG P, AHN H, DEPAULO J. Symptomatic, Familial, Perinatal, and Social Correlates of Computerized Axial Tomography (CAT) Changes in Schizophrenics and Bipolars. The Journal Of Nervous And Mental Disease 1985, 173: 42-50. PMID: 3965611, DOI: 10.1097/00005053-198501000-00007.Peer-Reviewed Original ResearchConceptsVentricular enlargementFamily historyNegative symptomsComputerized axial tomography scanLateral ventricular enlargementAxial tomography scanPast psychiatric historyEarly brain damageMarked ventricular enlargementSubgroup of schizophrenicsPoor premorbid adjustmentLateral ventricularTomography changesBrain ratioPatient groupBrain damageTomography scanPsychiatric illnessPsychiatric historyBipolar patientsNormal controlsEarly onsetPatientsPremorbid adjustmentSignificant proportion
1984
Lateral ventricular enlargement associated with persistent unemployment and negative symptoms in both schizophrenia and bipolar disorder
Pearlson G, Garbacz D, Breakey W, Ahn H, DePaulo J. Lateral ventricular enlargement associated with persistent unemployment and negative symptoms in both schizophrenia and bipolar disorder. Psychiatry Research 1984, 12: 1-9. PMID: 6589656, DOI: 10.1016/0165-1781(84)90133-1.Peer-Reviewed Original Research