2020
O2.6. DELUSIONS ASSOCIATED WITH ABNORMAL FRONTOSTRIATAL EFFECTIVE CONNECTIVITY IN A SPECTRAL DCM ANALYSIS OF RESTING STATE FMRI
Okuneye V, Clementz B, Gershon E, Keshavan M, McDowell J, Pearlson G, Tamminga C, Sweeney J, Keedy S. O2.6. DELUSIONS ASSOCIATED WITH ABNORMAL FRONTOSTRIATAL EFFECTIVE CONNECTIVITY IN A SPECTRAL DCM ANALYSIS OF RESTING STATE FMRI. Schizophrenia Bulletin 2020, 46: s5-s5. PMCID: PMC7234244, DOI: 10.1093/schbul/sbaa028.011.Peer-Reviewed Original ResearchR-DLPFCEffective connectivityState effective connectivityDelusional severityPrefrontal cortexState fMRIRight dorsolateral prefrontal cortexVentrolateral prefrontal cortexDynamic causal modelingDorsolateral prefrontal cortexSignificant effective connectivityEffective connectivity resultsEffective connectivity differencesSpectral dynamic causal modelingResting-state fMRISubcortical brain regionsIntermediate Phenotypes (B-SNIP) studyNeurocognitive processesFMRI studyFrontostriatal connectivityPrediction errorVLPFCFalse beliefsDelusion severityDLPFC
2018
145. Diagnosis and Biotype Comparisons Across the Psychosis Spectrum: Investigating Amygdala-Hippocampal Differences From the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) Study
Guimond S, Kelly S, Mike L, Chakravarty M, Sweeney J, Pearlson G, Clementz B, Tamminga C, Keshavan M. 145. Diagnosis and Biotype Comparisons Across the Psychosis Spectrum: Investigating Amygdala-Hippocampal Differences From the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) Study. Biological Psychiatry 2018, 83: s59. DOI: 10.1016/j.biopsych.2018.02.163.Peer-Reviewed Original ResearchT22. PITUITARY GLAND VOLUME DIFFERENCES IN INDIVIDUALS WITH PSYCHOSIS: RESULTS FROM THE BIPOLAR-SCHIZOPHRENIA NETWORK ON INTERMEDIATE PHENOTYPES (B-SNIP) STUDY
Guimond S, Tingue S, Devenyi G, Tang Y, Mike L, Chakravarty M, Sweeney J, Pearlson G, Clementz B, Tamminga C, Keshavan M. T22. PITUITARY GLAND VOLUME DIFFERENCES IN INDIVIDUALS WITH PSYCHOSIS: RESULTS FROM THE BIPOLAR-SCHIZOPHRENIA NETWORK ON INTERMEDIATE PHENOTYPES (B-SNIP) STUDY. Schizophrenia Bulletin 2018, 44: s121-s121. PMCID: PMC5888564, DOI: 10.1093/schbul/sby016.298.Peer-Reviewed Original ResearchPituitary gland volumeLarger pituitary glandsDuration of illnessHealthy controlsGland volumePituitary glandPsychotic bipolar disorderSymptom severityBipolar-Schizophrenia NetworkPituitary volumeSchizoaffective disorderLarger pituitary gland volumesClinical diagnosisLarger pituitary volumeSubgroup of patientsSignificant main effectGreater symptom severitySignificant subgroup differencesIndependent t-testAdrenal axisPatient groupIntermediate Phenotypes (B-SNIP) consortiumMAGeT Brain algorithmStructural magnetic resonance imagesIntermediate Phenotypes (B-SNIP) study
2017
965 Investigating Brain Structure Across Bipolar Disorder Subtypes: Findings from the Psychosis Affective Research Domain Intermediate Phenotypes (PARDIP) Study
Lutz O, Lizano P, Mothi S, Tandon N, Tamminga C, Clementz B, Sweeney J, Pearlson G, Keshavan M. 965 Investigating Brain Structure Across Bipolar Disorder Subtypes: Findings from the Psychosis Affective Research Domain Intermediate Phenotypes (PARDIP) Study. Biological Psychiatry 2017, 81: s390-s391. DOI: 10.1016/j.biopsych.2017.02.691.Peer-Reviewed Original ResearchSA64. Hallucination Severity Predicted by Auditory Cortex Resting State Connectivity in Bipolar and Schizophrenia Network on Intermediate Phenotypes Study
Okuneye V, Meda S, Keshavan M, Sweeney J, Tamminga C, Pearlson G, Gershon E, Keedy S. SA64. Hallucination Severity Predicted by Auditory Cortex Resting State Connectivity in Bipolar and Schizophrenia Network on Intermediate Phenotypes Study. Schizophrenia Bulletin 2017, 43: s136-s136. PMCID: PMC5475960, DOI: 10.1093/schbul/sbx023.063.Peer-Reviewed Original ResearchAuditory cortexHallucination severityState connectivityPsychosis patientsSignificant negative associationIntermediate Phenotypes (B-SNIP) studySchizophrenia NetworkResting-state connectivityAbnormal activation patternsBrodmann area 22Primary auditory cortexSecondary auditory cortexRight orbitofrontal cortexPrevious functional imaging studiesPhenotype studiesClinical rating scalesAuditory processing areasPossible common pathwayFunctional imaging studiesMiddle temporal cortexNegative associationPsychosis subjectsHealthy controlsHealthy subjectsConnectivity dysfunctionAPPLYING MULTIVARIATE TECHNIQUES, INCLUDING PARALLEL ICA TO COMMON COMPLEX PSYCHIATRIC ENDOPHENOTYPES
Pearlson G, Meda, Khadka S, Tamminga C, Keshavan M, Clementz B, Sweeney J, Gershon E, Raskin S, Fallahi C. APPLYING MULTIVARIATE TECHNIQUES, INCLUDING PARALLEL ICA TO COMMON COMPLEX PSYCHIATRIC ENDOPHENOTYPES. European Neuropsychopharmacology 2017, 27: s519. DOI: 10.1016/j.euroneuro.2016.09.636.Peer-Reviewed Original ResearchNeuron differentiationMultiple risk genesState functional MRIMolecular biological pathwaysComplex psychiatric diseasesSynaptic contactsBipolar-Schizophrenia NetworkEnrichment analysisUnivariate analysisMedical disordersIntermediate Phenotypes (B-SNIP) studyPsychiatric diseasesLarger sample sizeDisease riskEEG phenotypesFunctional MRISchizophrenia NetworkState EEG dataElectrophysiological phenotypeInterneuron developmentGenome-Wide Association Studies Of Smooth Pursuit Eye Movements Across Psychotic Disorders: Preliminary Findings From The B-Snip Sample
Lencer R, Mills L, Alliey-Rodriguez N, Reilly J, Sprenger A, McDowell J, Keshavan M, Pearlson G, McCarroll S, Tamminga C, Clementz B, Gershon E, Sweeney J, Bishop J. Genome-Wide Association Studies Of Smooth Pursuit Eye Movements Across Psychotic Disorders: Preliminary Findings From The B-Snip Sample. European Neuropsychopharmacology 2017, 27: s489. DOI: 10.1016/j.euroneuro.2016.09.580.Peer-Reviewed Original ResearchPursuit maintenancePsychotic disordersSmooth pursuit eye movementsSensorimotor processingEye movement dysfunctionSignificant neurological disordersSevere mental illnessRecent substance abusePursuit eye movementsYears of ageFunctional brain systemsPursuit deficitSensorimotor deficitsPursuit initiationBipolar-Schizophrenia NetworkPsychosis probandsEye accelerationMovement dysfunctionInterhemispheric connectionsIntermediate Phenotypes (B-SNIP) studyNeurophysiological consequencesPrimary analysisBipolar disorderMental illnessNeurological disorders
2013
Resting State Electroencephalogram Oscillatory Abnormalities in Schizophrenia and Psychotic Bipolar Patients and Their Relatives from the Bipolar and Schizophrenia Network on Intermediate Phenotypes Study
Narayanan B, O’Neil K, Berwise C, Stevens MC, Calhoun VD, Clementz BA, Tamminga CA, Sweeney JA, Keshavan MS, Pearlson GD. Resting State Electroencephalogram Oscillatory Abnormalities in Schizophrenia and Psychotic Bipolar Patients and Their Relatives from the Bipolar and Schizophrenia Network on Intermediate Phenotypes Study. Biological Psychiatry 2013, 76: 456-465. PMID: 24439302, PMCID: PMC5045030, DOI: 10.1016/j.biopsych.2013.12.008.Peer-Reviewed Original ResearchConceptsFirst-degree relativesSlow beta activityFast alpha activitySZ probandsAlpha activityHealthy control subjectsBeta activityRelative risk estimatesFrontal delta activityEEG spectral activityModerate relative riskPsychotic bipolar patientsLow-frequency activityPsychotic bipolar probandsGroup independent component analysisControl subjectsRelative riskPost-hoc pair-wise comparisonsBipolar patientsGenetic predispositionIntermediate Phenotypes (B-SNIP) studyOscillatory abnormalitiesAnalysis of covarianceUnique endophenotypesBipolar disorder