2019
Blood-based protein mediators of senility with replications across biofluids and cohorts
Royall D, Palmer R, Weiner M, Aisen P, Weiner M, Petersen R, Jack C, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Saykin A, Morris J, Shaw L, Khachaturian Z, Sorensen G, Carrillo M, Kuller L, Raichle M, Paul S, Davies P, Fillit H, Hefti F, Holtzman D, Mesulam M, Potter W, Snyder P, Montine T, Jimenez G, Donohue M, Gessert D, Harless K, Salazar J, Cabrera Y, Walter S, Hergesheimer L, Harvey D, Lee V, Korecka M, Figurski M, Thal L, Thal L, Buckholtz N, Snyder P, Albert M, Frank R, Quinn J, Silbert L, Lind B, Kaye J, Carter R, Dolen S, Schneider L, Pawluczyk S, Becerra M, Teodoro L, Spann B, Brewer J, Vanderswag H, Fleisher A, Ziolkowski J, Heidebrink J, Lord J, Mason S, Albers C, Knopman D, Johnson K, Villanueva-Meyer J, Pavlik V, Pacini N, Lamb A, Kass J, Doody R, Shibley V, Chowdhury M, Rountree S, Dang M, Stern Y, Honig L, Bell K, Yeh R, Ances B, Morris J, Winkfield D, Carroll M, Oliver A, Creech M, Mintun M, Schneider S, Marson D, Geldmacher D, Love M, Griffith R, Clark D, Brockington J, Grossman H, Mitsis E, Shah R, Lamar M, Samuels P, Duara R, Greig-Custo M, Rodriguez R, Onyike C, D’Agostino D, Sheikh S, Singleton-Garvin J, Ulysse A, Gaikwad M, Doraiswamy P, Petrella J, James O, Borges-Neto S, Wong T, Coleman E, Karlawish J, Wolk D, Vaishnavi S, Clark C, Arnold S, Smith C, Jicha G, Hardy P, Khouli R, Oates E, Conrad G, Lopez O, Oakley M, Simpson D, Porsteinsson A, Martin K, Kowalksi N, Keltz M, Goldstein B, Makino K, Ismail M, Brand C, Thai G, Pierce A, Yanez B, Sosa E, Witbracht M, Womack K, Mathews D, Quiceno M, Levey A, Lah J, Cellar J, Burns J, Swerdlow R, Brooks W, Woo E, Silverman D, Teng E, Kremen S, Apostolova L, Tingus K, Lu P, Bartzokis G, Graff-Radford N, Parfitt F, Poki-Walker K, Farlow M, Hake A, Matthews B, Brosch J, Herring S, van Dyck C, Carson R, Varma P, Chertkow H, Bergman H, Hosein C, Kielb M, Black S, Stefanovic B, Heyn C, Hsiung G, Mudge B, Sossi V, Feldman H, Assaly M, Finger E, Pasternack S, Pavlosky W, Rachinsky I, Drost D, Kertesz A, Bernick C, Munic D, Mesulam M, Rogalski E, Lipowski K, Weintraub S, Bonakdarpour B, Kerwin D, Wu C, Johnson N, Sadowsky C, Villena T, Turner R, Johnson K, Reynolds B, Sperling R, Johnson K, Marshall G, Yesavage J, Taylor J, Chao S, Lane B, Rosen A, Tinklenberg J, Zamrini E, Belden C, Sirrel S, Kowall N, Killiany R, Budson A, Norbash A, Johnson P, Obisesan T, Oyonumo N, Allard J, Ogunlana O, Lerner A, Ogrocki P, Tatsuoka C, Fatica P, Fletcher E, Maillard P, Olichney J, DeCarli C, Carmichael O, Kittur S, Borrie M, Lee T, Bartha R, Johnson S, Asthana S, Carlsson C, Tariot P, Burke A, Hetelle J, DeMarco K, Trncic N, Reeder S, Bates V, Capote H, Rainka M, Scharre D, Kataki M, Tarawneh R, Zimmerman E, Celmins D, Hart D, Pearlson G, Blank K, Anderson K, Flashman L, Seltzer M, Hynes M, Santulli R, Sink K, Yang M, Mintz A, Ott B, Tremont G, Daiello L, Salloway S, Malloy P, Correia S, Lee A, Rosen H, Miller B, Perry D, Mintzer J, Spicer K, Bachman D, Pasternak S, Rogers J, Pomara N, Hernando R, Sarrael A, Miller D, Smith K, Koleva H, Nam K, Shim H, Schultz S, Relkin N, Chiang G, Lin M, Ravdin L, Smith A, Leach C, Raj B, Fargher K, Bodge C. Blood-based protein mediators of senility with replications across biofluids and cohorts. Brain Communications 2019, 2: fcz036. PMID: 32954311, PMCID: PMC7425523, DOI: 10.1093/braincomms/fcz036.Peer-Reviewed Original ResearchDementia severityTexas Alzheimer's ResearchCare ConsortiumDisease Neuroimaging InitiativeAlzheimer's ResearchBlood-based protein biomarkersBody mass indexFollicle-stimulating hormoneLow-density lipoproteinAlzheimer's Disease Neuroimaging InitiativeLatent dementia phenotypeMass indexAge-specific effectsAge effectsDementia phenotypePancreatic polypeptideCognitive frailtyDisease processCognitive declineSeverityProtein mediatorsBiomarkersUnique effectsMediatorsCognitive performance measures
2013
Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity
Jahanshad N, Rajagopalan P, Hua X, Hibar D, Nir T, Toga A, Jack C, Saykin A, Green R, Weiner M, Medland S, Montgomery G, Hansell N, McMahon K, de Zubicaray G, Martin N, Wright M, Thompson P, Weiner M, Aisen P, Weiner M, Aisen P, Petersen R, Jack C, Jagust W, Trojanowski J, Toga A, Beckett L, Green R, Saykin A, Morris J, Liu E, Green R, Montine T, Petersen R, Aisen P, Gamst A, Thomas R, Donohue M, Walter S, Gessert D, Sather T, Beckett L, Harvey D, Gamst A, Donohue M, Kornak J, Jack C, Dale A, Bernstein M, Felmlee J, Fox N, Thompson P, Schuff N, Alexander G, DeCarli C, Jagust W, Bandy D, Koeppe R, Foster N, Reiman E, Chen K, Mathis C, Morris J, Cairns N, Taylor-Reinwald L, Trojanowki J, Shaw L, Lee V, Korecka M, Toga A, Crawford K, Neu S, Saykin A, Foroud T, Potkin S, Shen L, Khachaturian Z, Frank R, Snyder P, Molchan S, Kaye J, Quinn J, Lind B, Dolen S, Schneider L, Pawluczyk S, Spann B, Brewer J, Vanderswag H, Heidebrink J, Lord J, Petersen R, Johnson K, Doody R, Villanueva-Meyer J, Chowdhury M, Stern Y, Honig L, Bell K, Morris J, Ances B, Carroll M, Leon S, Mintun M, Schneider S, Marson D, Griffith R, Clark D, Grossman H, Mitsis E, Romirowsky A, deToledo-Morrell L, Shah R, Duara R, Varon D, Roberts P, Albert M, Onyike C, Kielb S, Rusinek H, de Leon M, Glodzik L, De Santi S, Doraiswamy P, Petrella J, Coleman R, Arnold S, Karlawish J, Wolk D, Smith C, Jicha G, Hardy P, Lopez O, Oakley M, Simpson D, Porsteinsson A, Goldstein B, Martin K, Makino K, Ismail M, Brand C, Mulnard R, Thai G, Mc-Adams-Ortiz C, Womack K, Mathews D, Quiceno M, Diaz-Arrastia R, King R, Weiner M, Martin-Cook K, DeVous M, Levey A, Lah J, Cellar J, Burns J, Anderson H, Swerdlow R, Apostolova L, Lu P, Bartzokis G, Silverman D, Graff-Radford N, Parfitt F, Johnson H, Farlow M, Hake A, Matthews B, Herring S, van Dyck C, Carson R, MacAvoy M, Chertkow H, Bergman H, Hosein C, Black S, Stefanovic B, Caldwell C, Hsiung G, Feldman H, Mudge B, Assaly M, Kertesz A, Rogers J, Trost D, Bernick C, Munic D, Kerwin D, Mesulam M, Lipowski K, Wu C, Johnson N, Sadowsky C, Martinez W, Villena T, Turner R, Johnson K, Reynolds B, Sperling R, Johnson K, Marshall G, Frey M, Yesavage J, Taylor J, Lane B, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Kowall N, Killiany R, Budson A, Norbash A, Johnson P, Obisesan T, Wolday S, Bwayo S, Lerner A, Hudson L, Ogrocki P, Fletcher E, Carmichael O, Olichney J, DeCarli C, Kittur S, Borrie M, Lee T, Bartha R, Johnson S, Asthana S, Carlsson C, Potkin S, Preda A, Nguyen D, Tariot P, Fleisher A, Reeder S, Bates V, Capote H, Rainka M, Scharre D, Kataki M, Zimmerman E, Celmins D, Brown A, Pearlson G, Blank K, Anderson K, Saykin A, Santulli R, Schwartz E, Sink K, Williamson J, Garg P, Watkins F, Ott B, Querfurth H, Tremont G, Salloway S, Malloy P, Correia S, Rosen H, Miller B, Mintzer J, Longmire C, Spicer K, Finger E, Rachinsky I, Rogers J, Kertesz A, Drost D. Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 4768-4773. PMID: 23471985, PMCID: PMC3606977, DOI: 10.1073/pnas.1216206110.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlzheimer DiseaseAutistic DisorderBrainChromosomes, Human, Pair 11Endosomal Sorting Complexes Required for TransportExtracellular Matrix ProteinsFemaleGenetic VariationGenome-Wide Association StudyHumansMagnetic Resonance ImagingMaleNedd4 Ubiquitin Protein LigasesRadiographySeverity of Illness IndexTwins, DizygoticTwins, MonozygoticUbiquitin-Conjugating EnzymesUbiquitin-Protein LigasesConceptsAlzheimer's diseaseBrain connectionsHuman brain wiringDegree of dementiaAssociation of connectivityBrain connectivity patternsConnectivity patternsAberrant connectivityDementia scoreDementia severityElderly populationLower riskPsychiatric disordersHealthy young adult twinsPosthoc analysisBrain wiringBrain diseasesFamily-based studyDiseaseBrain structuresBrain connectivityOlder peopleGene variantsMental retardationYoung adult twins