2024
Enlarged pituitary gland volume: a possible state rather than trait marker of psychotic disorders.
Guimond S, Alftieh A, Devenyi G, Mike L, Chakravarty M, Shah J, Parker D, Sweeney J, Pearlson G, Clementz B, Tamminga C, Keshavan M. Enlarged pituitary gland volume: a possible state rather than trait marker of psychotic disorders. Psychological Medicine 2024, 54: 1835-1843. PMID: 38357733, PMCID: PMC11132920, DOI: 10.1017/s003329172300380x.Peer-Reviewed Original ResearchPituitary gland volumePsychotic disordersSymptom severityAntipsychotic doseIllness durationCognitive functionAssociated with greater symptom severitySignificant effect of diagnosisAssociated with symptom severityHigher antipsychotic dosePituitary volumeBipolar-Schizophrenia NetworkIntermediate Phenotypes consortiumStructural magnetic resonance imagingProgression of psychosisGreater symptom severityEffect of diagnosisLower cognitive functionMore severe symptomsSample of individualsTransdiagnostic sampleMAGeT Brain algorithmGland volumeTrait markerBetween-group differences
2023
Double dissociation between P300 components and task switch error type in healthy but not psychosis participants
Huang L, Parker D, Ethridge L, Hamm J, Keedy S, Tamminga C, Pearlson G, Keshavan M, Hill S, Sweeney J, McDowell J, Clementz B. Double dissociation between P300 components and task switch error type in healthy but not psychosis participants. Schizophrenia Research 2023, 261: 161-169. PMID: 37776647, PMCID: PMC11015813, DOI: 10.1016/j.schres.2023.09.025.Peer-Reviewed Original ResearchConceptsEvent-related potentialsDouble dissociationParietal P300Oddball taskCognitive functionPsychosis participantsInductive reasoningP300 event-related potentialFrontal P300 amplitudePossible neural correlatesMental flexibilityCognitive demandsMemory maintenanceNeural correlatesPerseverative errorsRegressive errorsBehavioral performanceOddball targetsP300 componentP300 amplitudeError typesSubjects' abilityNeural activityP300 reductionHealthy participants
2020
O10.6. ANTERIOR VERSUS POSTERIOR HIPPOCAMPUS WITHIN PSYCHOSIS: A BSNIP STUDY
del Re E, Zeng V, Lutz O, Pearlson G, Sweeney J, Clementz B, Gershon E, Keedy S, Ivleva E, Tamminga C, Keshavan M. O10.6. ANTERIOR VERSUS POSTERIOR HIPPOCAMPUS WITHIN PSYCHOSIS: A BSNIP STUDY. Schizophrenia Bulletin 2020, 46: s26-s27. PMCID: PMC7233936, DOI: 10.1093/schbul/sbaa028.060.Peer-Reviewed Original ResearchDiagnostic groupsSum of anteriorAnterior portionGrouping of patientsMedial temporal lobe structuresTemporal lobe structuresBiotype 1Biotype 3T MRI dataBiotype 2Right subiculumHealthy controlsSubfield volumesFreeSurfer 6.0Whole hippocampusMorphometric findingsClinical ratingsHealthy populationHippocampusBipolar disorderAnatomical divisionsPosterior divisionSA disordersCognitive functionVolume decrease
2019
Type 2 diabetes mellitus, brain atrophy, and cognitive decline.
Moran C, Beare R, Wang W, Callisaya M, Srikanth V, Weiner M, Aisen P, Weiner M, Aisen P, Petersen R, Jack C, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Saykin A, Morris J, Liu E, Green R, Montine T, Petersen R, Aisen P, Gamst A, Thomas R, Donohue M, Walter S, Gessert D, Sather T, Beckett L, Harvey D, Gamst A, Donohue M, Kornak J, Jack C, Dale A, Bernstein M, Felmlee J, Fox N, Thompson P, Schuff N, Alexander G, DeCarli C, Jagust W, Bandy D, Koeppe R, Foster N, Reiman E, Chen K, Mathis C, Morris J, Cairns N, Taylor-Reinwald L, Trojanowki J, Shaw L, Lee V, Korecka M, Toga A, Crawford K, Neu S, Saykin A, Foroud T, Potkin S, Shen L, Kachaturian Z, Frank R, Snyder P, Molchan S, Kaye J, Quinn J, Lind B, Dolen S, Schneider L, Pawluczyk S, Spann B, Brewer J, Vanderswag H, Heidebrink J, Lord J, Petersen R, Johnson K, Doody R, Villanueva-Meyer J, Chowdhury M, Stern Y, Honig L, Bell K, Morris J, Ances B, Carroll M, Leon S, Mintun M, Schneider S, Marson D, Griffith R, Clark D, Grossman H, Mitsis E, Romirowsky A, deToledo-Morrell L, Shah R, Duara R, Varon D, Roberts P, Albert M, Onyike C, Kielb S, Rusinek H, de Leon M, Glodzik L, De Santi S, Doraiswamy P, Petrella J, Coleman R, Arnold S, Karlawish J, Wolk D, Smith C, Jicha G, Hardy P, Lopez O, Oakley M, Simpson D, Porsteinsson A, Goldstein B, Martin K, Makino K, Ismail M, Brand C, Mulnard R, Thai G, McAdams-Ortiz C, Womack K, Mathews D, Quiceno M, Diaz-Arrastia R, King R, Weiner M, Martin-Cook K, DeVous M, Levey A, Lah J, Cellar J, Burns J, Anderson H, Swerdlow R, Apostolova L, Lu P, Bartzokis G, Silverman D, Graff-Radford N, Parfitt F, Johnson H, Farlow M, Hake A, Matthews B, Herring S, van Dyck C, Carson R, MacAvoy M, Chertkow H, Bergman H, Hosein C, Black S, Stefanovic B, Caldwell C, Robin Hsiung G, Feldman H, Mudge B, Assaly M, Kertesz A, Rogers J, Trost D, Bernick C, Munic D, Kerwin D, Mesulam M, Lipowski K, Wu C, Johnson N, Sadowsky C, Martinez W, Villena T, Turner R, Johnson K, Reynolds B, Sperling R, Johnson K, Marshall G, Frey M, Yesavage J, Taylor J, Lane B, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Kowall N, Killiany R, Budson A, Norbash A, Johnson P, Obisesan T, Wolday S, Bwayo S, Lerner A, Hudson L, Ogrocki P, Fletcher E, Carmichael O, Olichney J, DeCarli C, Kittur S, Borrie M, Lee T, Bartha D, Johnson S, Asthana S, Carlsson C, Potkin S, Preda A, Nguyen D, Tariot P, Fleisher A, Reeder S, Bates V, Capote H, Rainka M, Scharre D, Kataki M, Zimmerman E, Celmins D, Brown A, Pearlson G, Blank K, Anderson K, Saykin A, Santulli R, Schwartz E, Sink K, Williamson J, Garg P, Watkins F, Ott B, Querfurth H, Tremont G, Salloway S, Malloy P, Correia S, Rosen H, Miller B, Mintzer J, Longmire C, Spicer K, Finger E, Rachinsky I, Rogers J, Kertesz A, Drost D, Pomara N, Hernando R, Sarrael A, Schultz S, Boles Ponto L, Shim H, Smith K, Relkin N, Chaing G, Raudin L, Smith A, Fargher K, Raj B. Type 2 diabetes mellitus, brain atrophy, and cognitive decline. Neurology 2019, 92: e823-e830. PMID: 30674592, PMCID: PMC7987953, DOI: 10.1212/wnl.0000000000006955.Peer-Reviewed Original ResearchConceptsBaseline cortical thicknessType 2 diabetes mellitusCortical thicknessCognitive declineAlzheimer's diseaseCognitive functionDiabetes mellitusCerebrovascular disease burdenGlucose-lowering agentsPresence of T2DMLower cortical thicknessLongitudinal relationshipAlzheimer's Disease Neuroimaging Initiative (ADNI) cohortMild cognitive impairmentStudy entryBrain atrophyBlood glucoseDisease burdenInitiative cohortT2DMBrain MRICognitive impairmentNormal cognitionRelevant covariatesOlder people
2010
Changes in Memory Function and Neuronal Activation Associated with Atorvastatin Therapy
Parker B, Polk D, Rabdiya V, Meda S, Anderson K, Hawkins K, Pearlson G, Thompson P. Changes in Memory Function and Neuronal Activation Associated with Atorvastatin Therapy. Pharmacotherapy The Journal Of Human Pharmacology And Drug Therapy 2010, 30: 625-625. DOI: 10.1592/phco.30.6.625.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingCognitive complaintsCognitive test performanceMemory taskCognitive testsFMRI findingsFMRI patternsCognitive testingCognitive functionMemory functionCognitive symptomsMemory impairmentTest performanceNeuronal activationBrain functionPreliminary evidenceObjective measuresMemory lossPsychiatric problemsAtorvastatin therapyMajor head traumaFirst case reportDays of cessationCentral nervous systemAlcohol consumption
1999
(Non)stationarity of temporal dynamics in fMRI
Calhoun V, Adali T, Pearlson G. (Non)stationarity of temporal dynamics in fMRI. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society 1999, 2: 1079 vol.2. DOI: 10.1109/iembs.1999.804239.Peer-Reviewed Original ResearchPrimary visual cortexFunctional MRIHemodynamic responseVisual cortexBrain regionsObserved hemodynamic responsesBlood supplyHigher cognitive functionsCognitive functionLatency shiftNeuronal patternsCortexAuthors' initial resultsCurrent studyFMRI experimentMean waveformOverall changeInitial resultsMRI
1996
CT measurement of suprasellar cistern predicts rate of cognitive decline in Alzheimer's disease
Aylward E, Rasmusson D, Brandt J, Raimundo L, Folstein M, Pearlson G. CT measurement of suprasellar cistern predicts rate of cognitive decline in Alzheimer's disease. Journal Of The International Neuropsychological Society 1996, 2: 89-95. PMID: 9375193, DOI: 10.1017/s135561770000093x.Peer-Reviewed Original ResearchConceptsSuprasellar cisternAlzheimer's diseaseAD patientsCT measuresQuantitative computed tomography (CT) measuresMini-Mental State Exam scoreCT measurementsComputed tomography measuresProbable Alzheimer's diseaseState Exam scoreBicaudate ratioBifrontal ratioNeurocognitive declineLateral ventricleThird ventricleCT scanTomography measuresCognitive declineCognitive functionPatientsAdaptive functioningDiseaseScansNeuropsychological measuresCognitive functioning