2024
Functional and structural effects of repetitive transcranial magnetic stimulation (rTMS) for the treatment of auditory verbal hallucinations in schizophrenia: A systematic review
Mehta D, Siddiqui S, Ward H, Steele V, Pearlson G, George T. Functional and structural effects of repetitive transcranial magnetic stimulation (rTMS) for the treatment of auditory verbal hallucinations in schizophrenia: A systematic review. Schizophrenia Research 2024, 267: 86-98. PMID: 38531161, DOI: 10.1016/j.schres.2024.03.016.Peer-Reviewed Original ResearchAuditory verbal hallucinationsRepetitive transcranial magnetic stimulationVerbal hallucinationsTranscranial magnetic stimulationTreatment-resistant auditory verbal hallucinationsAVH patientsTreatment of auditory verbal hallucinationsImpact of repetitive transcranial magnetic stimulationEmotion regulation regionsLanguage processing regionsAberrant neural activityHigh-frequency repetitive transcranial magnetic stimulationMagnetic stimulationRTMS interventionNeural substratesNeural effectsNeural mechanismsSham-controlled studySchizophreniaBrain activityNeuroimaging dataProcessing regionsNeuroimaging analysisNeuroimaging outcomesBrain abnormalities
1999
Structural brain imaging in schizophrenia: a selective review
Pearlson G, Marsh L. Structural brain imaging in schizophrenia: a selective review. Biological Psychiatry 1999, 46: 627-649. PMID: 10472416, DOI: 10.1016/s0006-3223(99)00071-2.Peer-Reviewed Original ResearchConceptsStructural neuroimaging studiesRegional brain volume abnormalitiesBrain structuresNeuroimaging studiesLateral ventricular enlargementPathophysiology of schizophreniaAbnormal brain structureBrain volume abnormalitiesComputed tomography studyNeuroanatomic pathologyVentricular enlargementBrain abnormalitiesAnatomic findingsVolume abnormalitiesStructural brainSchizophreniaTomography studySelective reviewAbnormalitiesConsistent evidenceBrainGenetic influencesReviewPathophysiologyFindings
1998
Brain changes in schizophrenia
Sharma T, Lancaster E, Lee D, Lewis S, Sigmundsson T, Takei N, Gurling H, Barta P, Pearlson G, Murray R. Brain changes in schizophrenia. The British Journal Of Psychiatry 1998, 173: 132-138. PMID: 9850225, DOI: 10.1192/bjp.173.2.132.Peer-Reviewed Original ResearchConceptsLarger lateral ventriclesControl subjectsUnrelated control subjectsLateral ventricleSmaller whole brainLateral ventricular enlargementStructural brain abnormalitiesNormal control subjectsObligate carriersGenetic liabilityVentricular enlargementSample of peopleBrain abnormalitiesBrain changesWhole brainCerebellar volumeBrain structuresMagnetic resonance imagesSchizophreniaVentricleUnaffected siblingsReconstructed magnetic resonance imagesResonance imagesAbnormalitiesVolumetric measurements
1997
Small planum temporale volume in Down's syndrome: a volumetric MRI study
Frangou S, Aylward E, Warren A, Sharma T, Barta P, Pearlson G. Small planum temporale volume in Down's syndrome: a volumetric MRI study. American Journal Of Psychiatry 1997, 154: 1424-1429. PMID: 9326826, DOI: 10.1176/ajp.154.10.1424.Peer-Reviewed Original ResearchConceptsPlanum temporale volumeSuperior temporal gyrusDown syndromeTemporal gyrusSyndrome patientsBrain volumePlanum temporaleMagnetic resonance imaging (MRI) measuresCommunity-dwelling patientsStructural brain abnormalitiesVolumetric MRI studyTotal brain volumeDown syndrome patientsHealthy comparison subjectsWhole brain volumeVolumetric magnetic resonance imaging (MRI) measuresAnatomic substrateBrain abnormalitiesHealthy subjectsComparison subjectsMRI studiesVolume deficitsSyndromeGyrusImaging measures
1996
Exploratory factor analysis of MRI brain structure measures in schizophrenia
Tien A, Eaton W, Schlaepfer T, McGilchrist I, Menon R, Richard P, Aylward E, Barta P, Strauss M, Pearlson G. Exploratory factor analysis of MRI brain structure measures in schizophrenia. Schizophrenia Research 1996, 19: 93-101. PMID: 8789907, DOI: 10.1016/0920-9964(96)88520-3.Peer-Reviewed Original ResearchConceptsSuperior temporal gyrusSchizophrenia groupNormal groupTemporal gyrusStructural brain abnormalitiesLateral temporal lobe structuresBrain volume measuresTemporal lobe structuresSpecific brain regionsPosterior superior temporal gyrusBrain structure measuresBasal gangliaBrain abnormalitiesCortical greyEntorhinal cortexBrain regionsSchizophrenic subjectsNeuropsychiatric dataLobe structuresSchizophreniaSignificant differencesSignificant correlationGray regionGyrusFactor structure
1992
Putamen volume reduction on magnetic resonance imaging exceeds caudate changes in mild Huntington's disease
Harris G, Pearlson G, Peyser C, Aylward E, Roberts J, Barta P, Chase G, Folstein S. Putamen volume reduction on magnetic resonance imaging exceeds caudate changes in mild Huntington's disease. Annals Of Neurology 1992, 31: 69-75. PMID: 1531910, DOI: 10.1002/ana.410310113.Peer-Reviewed Original ResearchConceptsMild Huntington's diseaseBicaudate ratioCaudate atrophyHuntington's diseaseHD patientsControl subjectsCaudate volumePutamen volumeSex-matched control subjectsNeurological examination scoresPutamen volume reductionsCharacteristic pathological featuresModerate Huntington's diseaseMagnetic resonance imagingCaudate changesNeostriatal atrophyNeuronal lossNeuroradiological studiesComputerized image analysis systemPathological featuresGreater atrophyBrain abnormalitiesCaudate nucleusAtrophyPatients
1989
Structural brain CT changes and cognitive deficits in elderly depressives with and without reversible dementia (‘pseudodementia’)*
Pearlson G, Rabins P, Kim W, Speedie L, Moberg P, Burns A, Bascom M. Structural brain CT changes and cognitive deficits in elderly depressives with and without reversible dementia (‘pseudodementia’)*. Psychological Medicine 1989, 19: 573-584. PMID: 2798631, DOI: 10.1017/s003329170002417x.Peer-Reviewed Original ResearchConceptsMini-Mental State ExaminationVentricular brain ratioAD patientsDepressed patientsNormal controlsDSM-III major depressionCognitive deficitsShort-term progressionStructural brain abnormalitiesCranial CT scanProbable Alzheimer's diseaseCT attenuation valuesCT valuesReversible dementiaElderly patientsMost patientsBrain ratioCT attenuation numbersCT changesElderly depressivesBrain abnormalitiesDementia syndromesMajor depressionCT scanPatients