Inhibitory Effect of Pregnancy on Counterregulatory Hormone Responses to Hypoglycemia in Awake Rat
Rossi G, Lapaczewski P, Diamond M, Jacob R, Shulman G, Sherwin R. Inhibitory Effect of Pregnancy on Counterregulatory Hormone Responses to Hypoglycemia in Awake Rat. Diabetes 1993, 42: 1440-1445. PMID: 8375583, DOI: 10.2337/diab.42.10.1440.Peer-Reviewed Original ResearchConceptsPregnant ratsGlucagon responseNonpregnant controlsAwake pregnant ratsCounterregulatory hormone responsesIntensive insulin treatmentRelease of epinephrineHypoglycemia risk factorsHypoglycemic clamp studiesDiabetic pregnanciesGlucose counterregulationMaternal hypoglycemiaHypoglycemic stimulusEpinephrine releaseEpinephrine levelsMild hypoglycemiaBrisk responseNonfasting stateRisk factorsAwake ratsInsulin treatmentKetone levelsClamp studiesGlucose levelsNonfasted stateComparative Effects of Monomethylsuccinate and Glucose on Insulin Secretion from Perifused Rat Islets
Zawalich W, Zawalich K, Cline G, Shulman G, Rasmussen H. Comparative Effects of Monomethylsuccinate and Glucose on Insulin Secretion from Perifused Rat Islets. Diabetes 1993, 42: 843-850. PMID: 8388341, DOI: 10.2337/diab.42.6.843.Peer-Reviewed Original ResearchConceptsPhosphoinositide hydrolysisInsulin secretionCalcium channel antagonist nitrendipineChannel antagonist nitrendipinePerifused rat isletsCalcium channel antagonistsSecond phase releaseGut hormone cholecystokininFirst-phase releaseInsulinotropic effectAntagonist nitrendipineSulfonylurea tolbutamideChannel antagonistsInsulin releaseHormone cholecystokininSubsequent stimulationGlucose-induced responseRat isletsSustained increaseStimulatory effectBiphasic patternMM glucoseMMSuccSecretionMonomethylsuccinate