2015
Transmission risk behaviour at enrolment in participants in the INSIGHT Strategic Timing of AntiRetroviral Treatment (START) trial
Rodger A, Lampe F, Grulich A, Fisher M, Friedland G, Phanuphak N, Bogner, Pereira L, Rietmeijer C, Burman W, Phillips A, Group I. Transmission risk behaviour at enrolment in participants in the INSIGHT Strategic Timing of AntiRetroviral Treatment (START) trial. HIV Medicine 2015, 16: 64-76. PMID: 25711325, PMCID: PMC4341939, DOI: 10.1111/hiv.12235.Peer-Reviewed Original ResearchConceptsAntiretroviral treatmentCondomless sexHIV-1 RNA copies/Risk behaviorsRegion of recruitmentSelf-reported risk behaviorsHIV viral loadHIV-positive participantsRNA copies/Transmission risk behaviorsHIV-positive peopleSubstantial proportionRecent sexual behaviorHeterosexual menSerodifferent partnersMedian ageRisk behavior questionnaireViral loadClinical statusLifestyle factorsBlack ethnicityCopies/Trial participantsStart StudyWhite ethnicity
2014
HIV Prevention Counseling Intervention Delivered During Routine Clinical Care Reduces HIV Risk Behavior in HIV-Infected South Africans Receiving Antiretroviral Therapy
Fisher JD, Cornman DH, Shuper PA, Christie S, Pillay S, Macdonald S, Ngcobo N, Amico KR, Lalloo U, Friedland G, Fisher WA. HIV Prevention Counseling Intervention Delivered During Routine Clinical Care Reduces HIV Risk Behavior in HIV-Infected South Africans Receiving Antiretroviral Therapy. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2014, 67: 499-507. PMID: 25230288, PMCID: PMC4229426, DOI: 10.1097/qai.0000000000000348.Peer-Reviewed Original ResearchConceptsHIV risk behaviorsAntiretroviral therapyClinical care sitesLay counsellorsRisk behaviorsCare sitesRoutine clinical careStandard of careClinical care settingsCounseling interventionHIV careViral suppressionPrimary outcomeHIV statusRoutine careCare counselingCare participantsEffective behavioral interventionsHIV epidemicHIV preventionIntervention participantsCare settingsClinical careBrief interventionInfection incidenceImproved survival in multidrug-resistant tuberculosis patients receiving integrated tuberculosis and antiretroviral treatment in the SAPiT Trial
Padayatchi N, Abdool Karim SS, Naidoo K, Grobler A, Friedland G. Improved survival in multidrug-resistant tuberculosis patients receiving integrated tuberculosis and antiretroviral treatment in the SAPiT Trial. The International Journal Of Tuberculosis And Lung Disease 2014, 18: 147-154. PMID: 24429305, PMCID: PMC4770013, DOI: 10.5588/ijtld.13.0627.Peer-Reviewed Original ResearchConceptsMultidrug-resistant tuberculosisMDR-TB patientsSequential treatment armAnti-tuberculosis treatmentAntiretroviral treatmentTreatment armsFirst-line anti-tuberculosis treatmentMultidrug-resistant tuberculosis patientsHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus infectionOut-patient clinicDrug susceptibility resultsSAPiT trialTuberculosis patientsClinical outcomesEarly initiationTherapeutic effectVirus infectionMortality ratePatientsTherapeutic outcomesSmall sample sizeTreatmentSusceptibility resultsTuberculosis
2006
Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa
Gandhi NR, Moll A, Sturm AW, Pawinski R, Govender T, Lalloo U, Zeller K, Andrews J, Friedland G. Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa. The Lancet 2006, 368: 1575-1580. PMID: 17084757, DOI: 10.1016/s0140-6736(06)69573-1.Peer-Reviewed Original ResearchConceptsDrug-resistant tuberculosisCo-infected patientsXDR tuberculosisMDR tuberculosisHIV co-infected patientsCulture-confirmed tuberculosisRecent hospital admissionTime of diagnosisSecond-line drugsDrug susceptibility testingCause of deathDate of deathHigh mortality rateAntiretroviral therapyMedian survivalHospital admissionSputum cultureHIV-1PatientsMortality rateHigh mortalityUrgent interventionTreatment programTuberculosisSusceptibility testingClinician-Delivered Intervention During Routine Clinical Care Reduces Unprotected Sexual Behavior Among HIV-Infected Patients
Fisher JD, Fisher WA, Cornman DH, Amico RK, Bryan A, Friedland GH. Clinician-Delivered Intervention During Routine Clinical Care Reduces Unprotected Sexual Behavior Among HIV-Infected Patients. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2006, 41: 44-52. PMID: 16340472, DOI: 10.1097/01.qai.0000192000.15777.5c.Peer-Reviewed Original ResearchConceptsCare control armUnprotected sexual behaviorInsertive oral sexHIV clinical careRoutine clinical careClinical careControl armAnal intercourseClinician-delivered interventionUnprotected sexSexual behaviorRoutine HIV clinical careOral sexLarge HIV clinicProspective clinical trialsIntervention arm participantsHIV prevention interventionsClinical care providersClient-centered interventionsHIV clinicArm participantsIntervention armClinical trialsPrevention interventionsCare providers
1996
Invasive Pneumococcal Disease: Clinical Features, Serotypes, and Antimicrobial Resistance Patterns in Cases Involving Patients with and Without Human Immunodeficiency Virus Infection
Frankel R, Virata M, Hardalo C, Altice F, Friedland G. Invasive Pneumococcal Disease: Clinical Features, Serotypes, and Antimicrobial Resistance Patterns in Cases Involving Patients with and Without Human Immunodeficiency Virus Infection. Clinical Infectious Diseases 1996, 23: 577-584. PMID: 8879783, DOI: 10.1093/clinids/23.3.577.Peer-Reviewed Original ResearchConceptsInvasive pneumococcal diseasePneumococcal diseaseClinical featuresPenicillin-resistant pneumococcal infectionsHuman immunodeficiency virus (HIV) diseaseHuman immunodeficiency virus (HIV) infectionCommon capsular typesSource of bacteremiaImmunodeficiency virus infectionOverall mortality rateAntibiotic susceptibility patternPolyvalent pneumococcal vaccineType 9VCommon risk factorsPenicillin-resistant isolatesAntimicrobial resistance patternsPneumococcal infectionPneumococcal vaccineHIV infectionHIV serostatusHIV statusRecurrence rateInvasive diseaseRisk factorsSusceptibility patterns
1991
Survival differences in patients with AIDS.
Friedland G, Saltzman B, Vileno J, Freeman K, Schrager L, Klein R. Survival differences in patients with AIDS. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1991, 4: 144-53. PMID: 1987352.Peer-Reviewed Original ResearchConceptsPneumocystis carinii pneumoniaFavorable survivalCarinii pneumoniaMale sexYounger ageRisk behaviorsInitial AIDS diagnosisSingle medical centerIntravenous drug usePoint of diagnosisInitial AIDSMedian survivalAIDS diagnosisBlack raceSurvival differencesKaposi's sarcomaMedical CenterClinical carePatientsDrug useAIDSSurvivalDiagnosisPowerful predictorMonths
1987
Febrile inpatients
Makadon H, Bor D, Friedland G, Dasse P, Komaroff A, Aronson M. Febrile inpatients. Journal Of General Internal Medicine 1987, 2: 293-297. PMID: 3655954, DOI: 10.1007/bf02596161.Peer-Reviewed Original ResearchConceptsLikelihood of bacteremiaBlood culturesMedical inpatientsHouse officersCause of feverOnset of feverEpisodes of feverCases of bacteremiaFebrile episodesFebrile patientsBacteremic patientsFever episodesFebrile inpatientsBacteremic episodesBacteremiaClinical judgmentFeverBacterial infectionsMedical house officersInpatientsEpisodesPatientsBloodSets of culturesAdequate substitute
1981
Infective endocarditis: an analysis based on strict case definitions.
Von Reyn C, Levy B, Arbeit R, Friedland G, Crumpacker C. Infective endocarditis: an analysis based on strict case definitions. Annals Of Internal Medicine 1981, 94: 505-18. PMID: 7011141, DOI: 10.7326/0003-4819-94-4-505.Peer-Reviewed Original ResearchConceptsStrict case definitionValvular diseaseCase definitionAdvanced mean ageShorter mean durationNosocomial endocarditisProsthesis endocarditisNeurologic eventsPossible endocarditisCardiac surgeryHeart failureInfective endocarditisMean ageMean durationEarly recognitionClinical studiesEndocarditisHigh incidenceInvasive proceduresViridans streptococciLarge seriesSuspect casesStaphylococcus aureusMortalityDisease
1979
Staphylococcal outbreak in an intensive care unit--a narrative account of its management.
du Moulin G, Dasse P, Miller M, Morrison M, Friedland G. Staphylococcal outbreak in an intensive care unit--a narrative account of its management. Heart & Lung 1979, 8: 94-9. PMID: 252511.Peer-Reviewed Original Research
1978
Pyrogen Reactions Associated with the Infusion of Normal Serum Albumin (Human)
Steere A, Rifaat M, Seligmann E, Hochstein H, Friedland G, Dasse P, Wustrack K, Axnick K, Barker L. Pyrogen Reactions Associated with the Infusion of Normal Serum Albumin (Human). Transfusion 1978, 18: 102-107. PMID: 625774, DOI: 10.1046/j.1537-2995.1978.18178118551.x.Peer-Reviewed Original ResearchConceptsNormal serum albuminEndotoxin concentrationsPyrogen reactionsLimulus testAlbumin infusionHospital surveillanceProspective studySame physicianRecurrent reactionsSingle patientPositive testPatientsLimulus amebocyte lysate testInfusionLimulus assaySerum albuminRabbit pyrogen testLysate testMedian concentrationsAlbuminPyrogen testSuspect reactions