2008
Episodic Antiretroviral Therapy Increases HIV Transmission Risk Compared With Continuous Therapy: Results of a Randomized Controlled Trial
Burman W, Grund B, Neuhaus J, Douglas J, Friedland G, Telzak E, Colebunders R, Paton N, Fisher M, Rietmeijer C. Episodic Antiretroviral Therapy Increases HIV Transmission Risk Compared With Continuous Therapy: Results of a Randomized Controlled Trial. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2008, 49: 142-150. PMID: 18769356, PMCID: PMC2749067, DOI: 10.1097/qai.0b013e318183a9ad.Peer-Reviewed Original ResearchConceptsHIV transmission riskHigh-risk behaviorsEpisodic antiretroviral therapyAntiretroviral therapyTransmission riskContinuous antiretroviral therapyHIV RNA levelsAntiretroviral Therapy studyProportion of participantsTherapy armContinuous therapyControlled TrialsRandomized armHIV transmissionMean ageNeedle sharingPatientsTherapyTherapy studiesStrategy of managementRNA levelsSexual activityRiskBaselineLaboratory testing
2002
The Consistency of Adherence to Antiretroviral Therapy Predicts Biologic Outcomes for Human Immunodeficiency Virus—Infected Persons in Clinical Trials
Mannheimer S, Friedland G, Matts J, Child C, Chesney M, AIDS T. The Consistency of Adherence to Antiretroviral Therapy Predicts Biologic Outcomes for Human Immunodeficiency Virus—Infected Persons in Clinical Trials. Clinical Infectious Diseases 2002, 34: 1115-1121. PMID: 11915001, DOI: 10.1086/339074.Peer-Reviewed Original ResearchConceptsHIV RNA levelsHuman immunodeficiency virusImmunodeficiency virusClinical trialsRNA levelsPlasma HIV RNA levelsBiologic outcomesConsistency of adherenceCopies/mLMulticenter clinical trialAntiretroviral therapyCD4 countMonth 12Nonwhite racePoor adherenceAdherence levelsAdherence patternsOlder ageGood adherenceAdherenceCells/TrialsVisitsOutcomesParticipants